Polymyxin B, polymyxin E, and colistin sulphomethate sodium are fungicidal for . Four hundred random isolates of from two hospital laboratories were tested for sensitivity to colistin: 25 (6.2 per cent.) were sensitive, and 22 of these were . One hundred and twelve isolates of eight species of were screened for sensitivity to colistin and, of the 14 that were sensitive, 12 were .

Polymyxins B and E liberate intracellular material from C. tropicalis, which suggests that the drug acts on the yeast cell-membrane.

Colistin sulphomethate was successfully used to treat a urinary-tract infection with this species of . The potential therapeutic value of polymyxins for infections is discussed.


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