1887

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Volume 3, Issue 2

Sensitivity Of Meningococci To Sodium Sulphadiazine And Six Antibiotics Free

Abstract

SUMMARY

One hundred and seventy strains of meningococci isolated in the UK from 1966 to 1968 were tested for sensitivity to sodium sulphadiazine. Eighty-eight strains were isolated from CSF or blood and 82 strains from postnasal swabs and other sources. Seven strains were resistant to sulphonamides: one was highly resistant (MIC 100 μg per ml), two were moderately resistant (MIC 50 μg per ml) and four were slightly resistant (MIC 6.4 or 10 μg per ml). One hundred and sixteen strains, including the seven sulphonamide-resistant strains, were tested for sensitivity to six antibiotics: benzyl-penicillin, ampicillin, erythromycin, tetracycline, chloramphenicol and cephaloridine. None of the strains showed any increase in resistance to these antibiotics.

One hundred and sixty strains were typed serologically: 15 (9 per cent.) were group A, 51 (32 per cent.) were group B and 94 (59 per cent.) were untypable.

  • Received:
  • Accepted:
  • Revised:
  • Published Online:
© J. MED. MICROBIOL. 1970
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1970-05-01
2024-12-14
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References

  1. Bristow W. M., Van Peenan P. F. D., Volk R. 1965 Amer. J. Publ. Hlth 55:1039
     [Google Scholar]
  2. British Medical Journal (Leading Article) 1966 Br. Med. J 1:1253
     [Google Scholar]
  3. Brown J. W., Condit P. K. 1965 California Med 102:171
     [Google Scholar]
  4. Dowd J. M., Blink D., Miller C. H., Frank P. F., Pierce W. E. 1966 J. Infect. Dis 116:473
     [Google Scholar]
  5. Eickhoff T. C., Finland M. 1965 New Engl. J. Med 272:395
     [Google Scholar]
  6. Fallon R. J., Brown W. 1966 Br. Med. J 1:1598
     [Google Scholar]
  7. Farrell D. G., Dahl E. V. 1966 J. Amer. Med. Assoc 198:1189
     [Google Scholar]
  8. Feldman H. A. 1965 Br. Med. J 1:436
     [Google Scholar]
  9. Florey M. Ethel. 1957; The clinical application of antibiotics 3, Chloramphenicol and the tetracyclines. Oxford PP 80–81
     [Google Scholar]
  10. Garrod L. P., O’Grady F. 1968 Antibiotic and Chemotherapy Edinburgh and London: PP 258 and 315
     [Google Scholar]
  11. Gauld J. R., Nitz R. E., Hunter D. H., Rust J. H., Gauld R. L. 1965 Amer. J. Epidem 82:56
     [Google Scholar]
  12. Ivler D., Leedom J. M., Mathies A. W. Jr, Fremont J. C., Thrupp L. D., Portnoy B., Wehrle P. F. 1965 In Antimicrobial agents and chemotherapy, 1964 Ed. by Hobby Gladys L. Ann Arbor: P 358
     [Google Scholar]
  13. Leedom J. M., Ivler D., Mathies A. W., Thrupp L. D., Portnoy B., Wehrle P. F. 1965 New Engl. J. Med 273:1395
     [Google Scholar]
  14. McKenzie P., Love W. C., Lawson J. H., Pinkerton I. W., Jamieson W. M., Stevenson J. 1967 Postgrad. Med. J 43: Suppl. on cephaloridine, P 142
     [Google Scholar]
  15. Mathies A. W. Jr, Leedom J. M., Thrupp L. D., Ivler D., Portnoy B., Wehrle P. F. 1965 In Antimicrobial agents and chemotherapy, 1964 Ed. by Hobby Gladys L. Ann Arbor: P 610
     [Google Scholar]
  16. Millar J. W., Siess E. E., Feldman H. A., Silverman C., Frank P. 1963 J. Amer. Med. Assoc 186:139
     [Google Scholar]
  17. Tarr H. A. 1958 Mon. Bull. Minist. Hlth 17:64
     [Google Scholar]
  18. Wiggins G. L., Schubert J. H. 1967 Bact. Proc P 96
     [Google Scholar]
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Sensitivity Of Meningococci To Sodium Sulphadiazine And Six Antibiotics
J. Med. Microbiol. 3, 233 (1970); https://doi.org/10.1099/00222615-3-2-233
/content/journal/jmm/10.1099/00222615-3-2-233
/content/journal/jmm/10.1099/00222615-3-2-233
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