One hundred and seventy strains of meningococci isolated in the UK from 1966 to 1968 were tested for sensitivity to sodium sulphadiazine. Eighty-eight strains were isolated from CSF or blood and 82 strains from postnasal swabs and other sources. Seven strains were resistant to sulphonamides: one was highly resistant (MIC 100 μg per ml), two were moderately resistant (MIC 50 μg per ml) and four were slightly resistant (MIC 6·4 or 10 μg per ml). One hundred and sixteen strains, including the seven sulphonamide-resistant strains, were tested for sensitivity to six antibiotics: benzyl-penicillin, ampicillin, erythromycin, tetracycline, chloramphenicol and cephaloridine. None of the strains showed any increase in resistance to these antibiotics.

One hundred and sixty strains were typed serologically: 15 (9 per cent.) were group A, 51 (32 per cent.) were group B and 94 (59 per cent.) were untypable.


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