Penicillin tolerance was elicited in 18 of 46 strains of viridans streptococci isolated from the mouths of 19 of 20 healthy subjects and in 31 of 54 consecutive blood-culture isolates of streptococci. Enterococci and were theorganisms most frequently tolerant but the property was also common among isolates of and Lancefield Group G streptococci. Pneumococci and were rarely tolerant. When incubated with penicillin at 5 x MIC in batch or continuous cultures, both tolerant and sensitive strains of oral streptococci declined in number less rapidly than However, combinations of penicillin and gentamicin killed tolerant and sensitive oral streptococci.


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