1887

Abstract

SUMMARY

The hydrolysis of methicillin by the penicillinase produced by 108 epidemiologically distinct methicillin-resistant strains of has been investigated. In no case is there evidence for a variant enzyme with increased efficiency of hydrolysis of methicillin. Cultures of penicillinase-negative variants of methicillin-resistant strains are heterogeneous in their resistance to methicillin. In all but one case, organisms resistant to a high concentration of methicillin revert to a heterogeneous resistance pattern on subculture in the absence of methicillin. Methicillin-resistant strains do not grow slowly in the absence of methicillin, but are more resistant to methicillin when grown at low temperature or when grown in the presence of sodium chloride. The mucopeptide of methicillin-resistant cells does not differ from that of methicillin-sensitive cells either in amount or composition. Possible mechanisms of methicillin resistance are discussed.

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1969-08-01
2022-01-21
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References

  1. Annear D. I. 1968 Med. J. Austral. 1:444
    [Google Scholar]
  2. Barber Mary. 1964 J. Gen. Microbiol. 35:183
    [Google Scholar]
  3. Baudens J. G., Gerbaud G. R., Chabbert Y. A. 1965 Annls Inst. Pasteur, Paris 109:372
    [Google Scholar]
  4. Chabbert Y. A., Baudens J. G. 1962 Ibid. 103:222
    [Google Scholar]
  5. Dyke K. G. H. 1967 Biochem. J. 103:641
    [Google Scholar]
  6. Dyke K. G. H., Jevons M. Patricia, Parker M. T. 1966 Lancet 1:835
    [Google Scholar]
  7. Eriksen K. R., Erichsen Ingrid. 1964 Acta path, microbiol. scand. 62:255
    [Google Scholar]
  8. Jevons M. Patricia. 1961 Br. Med. J. 1:124
    [Google Scholar]
  9. Jevons M. Patricia, Coe A. W., Parker M. T. 1963 Lancet 1:904
    [Google Scholar]
  10. Kagan B. M., Martin E. R., Stewart G. T. 1964 Nature, Lond. 203:1031
    [Google Scholar]
  11. Kayser F-H. 1965 Path. Microbiol. 28:985
    [Google Scholar]
  12. Knox R. 1961 Br. Med. J. 1:126
    [Google Scholar]
  13. Mandelstam J., Rogers H. J. 1959 Biochem. J. 72:654
    [Google Scholar]
  14. Novick R. P. 1962 Ibid. 83:229
    [Google Scholar]
  15. Novick R. P. 1963 J. Gen. Microbiol. 33:121
    [Google Scholar]
  16. Park J. T., Hancock R. 1960 Ibid. 22:249
    [Google Scholar]
  17. Parker M. T., Jevons M. Patricia. 1964 Post-grad. Med. J. 40:Suppl. p. 170
    [Google Scholar]
  18. Perkins H. R., Rogers H. J. 1959 Biochem. J. 72:647
    [Google Scholar]
  19. Perret C. J. 1954 Nature, Lond. 174:1012
    [Google Scholar]
  20. Pollock M. R. 1962 In Resistance of bacteria to the penicillins ed. by de Reuck A. V. S., Cameron M. P. London: p. 67
    [Google Scholar]
  21. Richmond M. H. 1965 Biochem. J. 94:584
    [Google Scholar]
  22. Richmond M. H., Parker M. T., Jevons M., Patricia John M. 1964 Lancet 1:293
    [Google Scholar]
  23. Rogers H. J. 1953 J. Path. Bad 66:545
    [Google Scholar]
  24. Rogers H. J., Jeljaszewicz J. 1961 Biochem. J. 81:576
    [Google Scholar]
  25. Rolinson G. N. 1961 Br. Med. J. 1:125
    [Google Scholar]
  26. Seligman S. J. 1966a Nature, Lond. 209:994
    [Google Scholar]
  27. Seligman S. J. 1966 J. Gen. Microbiol. 42:315
    [Google Scholar]
  28. Stewart G. T., Holt R. J. 1963 Br. Med. J. 1:308
    [Google Scholar]
  29. Sutherland R., Rolinson G. N. 1964 J. Bad. 87:887
    [Google Scholar]
  30. Swanstrom M., Adams M. H. 1951 Proc. Soc. Exp. Biol. Med. 78:372
    [Google Scholar]
  31. Yudkin J. 1953 Nature, Lond. 171:541
    [Google Scholar]
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