1887

Abstract

Summary

The cytopathic effects of standard inocula (30,000 blastospores per ml) of (isolated from man) on murine renal epithelial cells in culture were compared with those of (isolated from non-human sources). The nature of the changes in the mammalian cells, and the extent of their destruction, were shown to be correlated with the growth rate and with the proportion of mycelium in the growing fungi. The presence of mammalian cells induced filamentous change in some species.

These experiments demonstrate the greater importance of the M phase in the progression of Candida lesions, because of the more widespread involvement of cells by organisms with rapid growth rates, but they do not demonstrate a qualitative difference in the cytopathic effects of the M and Y phases. They suggest that the Y phase may initiate infection, as it does experimentally, and that the M phase is associated with the more rapidly growing species and with extension of the lesion. The filamentous phase may be induced by exposure of the fungi to cellular exudates or transudates.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-2-1-63
1969-02-01
2022-01-22
Loading full text...

Full text loading...

/deliver/fulltext/jmm/2/1/medmicro-2-1-63.html?itemId=/content/journal/jmm/10.1099/00222615-2-1-63&mimeType=html&fmt=ahah

References

  1. Beijerinck M. W. 1889 Archs néed. Sci. 23:428
    [Google Scholar]
  2. Cantrell H. F., Widra A. 1964 J. Bact. 87:1532
    [Google Scholar]
  3. Furness G. 1958 J. Infect. Dis. 103:272
    [Google Scholar]
  4. Haley Leonor D. 1965-66 Sabouraudia 4:98
    [Google Scholar]
  5. Holland J. J., Pickett M. J. 1956 Proc. Soc. Exp. Biol. Med. 93:476
    [Google Scholar]
  6. Isenberg H. D., Allerhand J., Berkman J. I. 1963 Nature, Lond. 197:516
    [Google Scholar]
  7. Koch H. A. 1965 Biologia, Bratislava 20:52
    [Google Scholar]
  8. Kozinn P. J., Taschdjian Claire L. 1962 Pediatrics 30:71
    [Google Scholar]
  9. Lodder J. 1934 Verh. K. Akad. Wet., 2nd Sect. 32:1
    [Google Scholar]
  10. Lodder J., Kreger-Van Rij N. J. W. 1967; The yeasts, a taxonomic study. Amsterdam
    [Google Scholar]
  11. Mackenzie D. W. R. 1965-66 Sabouraudia 4:126
    [Google Scholar]
  12. Mankowski Z. T. 1963 Mycopath. Mycol. appl. 19:1
    [Google Scholar]
  13. Murray I. G., Buckley Helen R. 1966 In Symposium on Candida infections. ed. by Winner H. I., Rosalinde Hurley. Edinburgh; London: p 44
    [Google Scholar]
  14. Rogers K. B. 1957 J. Clin. Path. 10:406
    [Google Scholar]
  15. Rogers K. B. 1966 In Symposium on Candida infections. ed. by Winner H. I., Rosalinde Hurley. Edinburgh and London: p 179
    [Google Scholar]
  16. Shepard C. C. 1957 J. Exp. Med. 105:39
    [Google Scholar]
  17. Stanley Valerie C. 1968 Ph.D. Thesis Univ; London:
  18. Stanley Valerie C., Hurley Rosalinde. 1967 J. Path. Bact. 94:301
    [Google Scholar]
  19. Taschdjian Claire L., Burchall J. J., Kozinn P. J. 1960 Amer. J. Dis. Child. 99:212
    [Google Scholar]
  20. Weyman-Rzucidlo Danuta. 1965 Acta microbiol. pol. 14:247
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-2-1-63
Loading
/content/journal/jmm/10.1099/00222615-2-1-63
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error