1887

Abstract

Summary

Antistreptolysin antibody (ASO) inhibits haemolysis of erythrocytes coated with streptolysin O (SLO), but antistreptolysin activity may also be due to the presence in sera of peptide fragments of altered lipoproteins. SLO-mediated haemolysis results from activity of a molecular site (the t site) distinct from that at which the SLO becomes attached to the cell (the f site), and both sites might be expected to function antigenically. Absorption studies with SLO-coated latex particles, and with SLO-coated erythrocytes in the cold, provide evidence for the existence of both classes of antibody. Results also suggest explanations for the frequent observation of false-negative and false-positive latex tests.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-19-1-1
1985-02-01
2022-01-26
Loading full text...

Full text loading...

/deliver/fulltext/jmm/19/1/medmicro-19-1-1.html?itemId=/content/journal/jmm/10.1099/00222615-19-1-1&mimeType=html&fmt=ahah

References

  1. Alouf J E, Raynaud M. 1968; Some aspects of the mechanisms of lysis of rabbit erythrocytes by streptolysin O. Caravano R. Current research on group A streptococcus Exerpta Medica Foundation; Amsterdam:192–206
    [Google Scholar]
  2. Burstein M, Samaille J. 1958; Sur une nouvelle méthode de dosage du cholesterol lié aux α et aux β-lipoprotéines du sérum. Clinica Chimica Acta 3:320–327
    [Google Scholar]
  3. Packalen T. 1948; Nonspecific antistreptolysin reactions and serum (or pleural-exudate) cholesterol. Journal of Bacteriology 56:143–156
    [Google Scholar]
  4. Rantz L A, Randall E. 1945; A modification of the technic for determination of the antistreptolysin titer. Proceedings of Society of Experimental Biology and Medicine 59:22–25
    [Google Scholar]
  5. Watson K C, Kerr E J C. 1974; Sterol structural requirements for inhibition of streptolysin O activity. Biochemical Journal 140:95–98
    [Google Scholar]
  6. Watson K C, Kerr E J C. 1975; Functional role of cholesterol in infection and autoimmunity. Lancet 1:308–310
    [Google Scholar]
  7. Watson K C, Kerr E J C. 1976; Studies on antistreptolysin O activity generated in serum by microorganisms. British Journal of Experimental Pathology 57:105–113
    [Google Scholar]
  8. Watson K C, Rose T P, Kerr E J C. 1972; Some factors influencing the effect of cholesterol on streptolysin O activity. Journal of Clinical Pathology 25:885–891
    [Google Scholar]
  9. Winblad S. 1966; Studies on non-specific antistreptolysin O titre I. The influence of serum β-lipoproteins on the non-specific antistreptolysin O titre. Acta Pathologica et Microbiologica Scandinavica 66:93–104
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-19-1-1
Loading
/content/journal/jmm/10.1099/00222615-19-1-1
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error