SUMMARY. Problems about the pathogenicity of an organism can be classified as: (1) clinical and epidemiological— diseases does it cause or take part in, and ? (2) research (with prophylactic and therapeutic implications)— does it do so? Category (1) answers for began in 1892, with Pfeiffer's claim that it was the cause of influenza; but the true picture of the range of pathogenic activities of this species became clear in the period 1930-1960. Category (2) answers have in general been more recent, and are still far from complete (as is the case with most pathogens); but a fascinating array of contributions has appeared in the past few years.


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