1887

Abstract

SUMMARY

Methicillin-resistant strains isolated at a single Melbourne Hospital between 1969 and 1981 were examined for susceptibility to a range of antimicrobial agents and for the presence of plasmid DNA. Isolates obtained during 1969 possessed a plasmid of mol. wt 20 × 10, encoding heavy metal resistance and penicillinase production, and a plasmid of mol. wt 2–8 × 10, mediating tetracycline resistance. In the majority of isolates obtained after 1973, these functions were chromosomally encoded. Before 1980, both high- and low-level chromosomally-encoded gentamicin resistances were encountered, whereas isolates from 1980 and 1981 displayed low-level gentamicin resistance only; the latter phenotype was most commonly mediated by a plasmid of mol. wt 18 × 10 that also encoded resistance to tobramycin and kanamycin. Chloramphenicol resistance in strains isolated throughout the period was mediated by one of three plasmids, each of mol. wt . 3 × 10.

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1984-06-01
2024-04-12
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