1887

Abstract

Summary.

Early antenatal serum specimens were collected from 25 women who subsequently gave birth to infants with anencephaly or spina bifida. Fluorescent-antibody tests for influenza-specific IgA and IgM antibodies, although shown to be reliable for the detection of recent influenzal infection, failed to demonstrate such infection in any of these women. Early infection was detected in one of 50 control women who gave birth to a healthy infant. The results indicate that influenzal infection in pregnancy was not a major cause of neural-tube defects in Oxford during 1972–76, if a cause at all.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-14-1-159
1981-02-01
2022-01-20
Loading full text...

Full text loading...

/deliver/fulltext/jmm/14/1/medmicro-14-1-159.html?itemId=/content/journal/jmm/10.1099/00222615-14-1-159&mimeType=html&fmt=ahah

References

  1. Buchner Y. I., Heath R. B., Collins J. V., Pattison J. R. 1977; Serum IgM antibody and influenza A infection. J. clin. Path 30:723
    [Google Scholar]
  2. Campbell W. A. B. 1953; Influenza in early pregnancy-effects on the foetus. Lancet 1:173
    [Google Scholar]
  3. Coffey V. P., Jessop W. J. E. 1959; Maternal influenza and congenital deformities, a prospective study. Lancet 2:935
    [Google Scholar]
  4. De Silva G. P. L. M. 1972; Studies on specific IgG, IgA and IgM fluorescent antibody levels as an aid to the rapid diagnosis of certain viral infections. Ph.D thesis Manchester University;
    [Google Scholar]
  5. De Silva L. M., Khan M. S., Kampfner G., Tobin J. O’H., Gillett R., Morris C. A. 1973; The post-mortem diagnosis of influenzal infection by fluorescent IgG, IgA and IgM antibody studies on necropsy blood. J. Hyg., Camb 71:107
    [Google Scholar]
  6. Doll R., Bradford-Hill A., Sakula J. 1960; Asian influenza in pregnancy and congenital defects. Br. J. prev. soc. Med 14:167
    [Google Scholar]
  7. Hakosalo J., Saxen L. 1971; Influenza epidemic and congenital defects. Lancet 2:1346
    [Google Scholar]
  8. Hardy J. M. B., Azarowicz E. N., Mannini A., Medearis D. N., Cooke R. E. 1961; The effect of Asian influenza on the outcome of pregnancy, Baltimore 1957-58. Am. J. publ. Hlth 51:1182
    [Google Scholar]
  9. Leck I. 1963; The incidence of malformations following influenza epidemics. Br. J. prev. soc. Med 17:70
    [Google Scholar]
  10. Pleydell M. J. 1960; Anencephaly and other congenital abnormalities. An epidemiological study in Northamptonshire. Br. med. J 1:309
    [Google Scholar]
  11. Public Health Laboratory Service Standing Advisory Committee on Influenza 1977; Influenza surveillance 1972-1975. J. Hyg., Camb 78:223
    [Google Scholar]
  12. Saxén L., Klemetti A., Härö A. S. 1974; A matched-pair register for studies of selected congenital defects. Am. J. Epidem 100:297
    [Google Scholar]
  13. Urquhart G. E. D. 1974; Serum IgM and IgA responses in influenza A infections. J. clin. Path 27:198
    [Google Scholar]
  14. Walker W. M., McKee A. P. 1959; Asian influenza in pregnancy—relationship to fetal anomalies. Obstet. Gynec, N.Y. 13:394
    [Google Scholar]
  15. Wilson M. G., Heins H. L., Imagawa D. T., Adams J. M. 1959; Teratogenic effects of Asian influenza. J. Am. med. Ass 171:638
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-14-1-159
Loading
/content/journal/jmm/10.1099/00222615-14-1-159
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error