Summary. The pathogenicity of 42 strains of of human origin was estimated by intracutaneous injection of bacterial suspensions into guinea-pig skin. Comparisons of living and heat-killed suspensions revealed that strains maintained themselves and possibly multiplied in the skin, whereas the lesions induced by non-fra-gilis strains appeared to be due mainly to toxicity. Measurement of skin pathogenicity in terms of the number of viable organisms in the inoculum that produced a lesion 10 mm in diameter showed that was, on average, 17 times as pathogenic as non-fragilis strains.

Skin tests of pathogens may be of value in the analysis of virulence factors of and possibly of other anaerobic organisms.


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