1887

Abstract

PLATES XXX-XXXII

THE ENZYME urease is thought to play a major role as a virulence factor in urinary-tract infections with (Braude and Siemienski, 1960) although it may not be the only factor (Eudy, Burrous and Sigler, 1971). Urease degrades urea with release of ammonia which may cause damage and death to the renal epithelium, inactivation of complement, and conditions favouring the development of renal stones. Many of these effects can be prevented by the administration of urease inhibitors (Griffith and Musher, 1973; Griffith, Musher and Campbell, 1973; Aronson, Medalia and Griffel, 1974; Musher , 1975).

Phillips (1955) found wide variation in the pathogenicity of different strains of for the mouse kidney , and Senior (1979) has shown that particular proticine-production/sensitivity (P/S) types of have a special affinity for the urinary tract whereas other P/S types and other species are seldom incriminated in serious urinary-tract infections. The aim of this study was to determine whether or not these differences in pathogenicity among strains of were associated with differences in the types of ureases produced by these strains.

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/content/journal/jmm/10.1099/00222615-13-4-507
1980-11-01
2022-05-20
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References

  1. Aronson M., Medalia O., Griffel B. 1974; Prevention of ascending pyelonephritis in mice by urease inhibitors. Nephron 12:94
    [Google Scholar]
  2. Blattler D. P., Contaxis C. C., Reithel F. J. 1967; Dissociation of urease by glycol and glycerol. Nature, Lond 216:274
    [Google Scholar]
  3. Braude A. I., Shapiro A. P., Siemienski J. 1959; Hematogenous pyelonephritis in rats, iii. Relationship of bacterial species to the pathogenesis of acute pyelonephritis. J. Bact 77:270
    [Google Scholar]
  4. Braude A. I., Siemienski J. 1960; Role of bacterial urease in experimental pyelonephritis. J. Bact 80:171
    [Google Scholar]
  5. Brenner D. J., Farmer J. J., Fanning G. R., Steigerwalt A. G., Klykken P., Wathen H. G., Hickman F. W., Ewing W. H. 1978; Deoxyribonucleic acid relatedness of Proteus and Providencia species. Int. J. syst. Bact 28:269
    [Google Scholar]
  6. Eudy W. W., Burrous S. E., Sigler F. W. 1971; Renal lysozyme levels in animals developing “sterile pyelonephritis”. Infect. Immun 4:269
    [Google Scholar]
  7. Fishbein W. N., Spears C. L., Scurzi W. 1969; Spectrum of urease isozymes: genetic, polymeric and conformeric. Nature, Lond 233:191
    [Google Scholar]
  8. Griffith D. P., Musher D. M. 1973; Prevention of infected urinary stones by urease inhibition. Invest. Urol 11:228
    [Google Scholar]
  9. Griffith D. P., Musher D. M., Campbell J. W. 1973; Inhibition of bacterial urease. Invest. Urol 11:234
    [Google Scholar]
  10. Guo M. M. S., Liu P. V. 1965; Serological specificities of ureases of Proteus species. J. gen. Microbiol 38:417
    [Google Scholar]
  11. Musher D. M., Griffith D. P., Yawn D., Rossen R. D. 1975; Role of urease in pyelonephritis resulting from urinary tract infection with Proteus. J. infect. Dis 131:177
    [Google Scholar]
  12. Phillips J. E. 1955; The experimental pathogenicity in mice of strains of Proteus of animal origin. J. Hyg., Camb 53:212
    [Google Scholar]
  13. Senior B. W. 1977; Typing of Proteus strains by proticine production and sensitivity. J. med. Microbiol 10:7
    [Google Scholar]
  14. Senior B. W. 1979; The special affinity of particular types of Proteus mirabilis for the urinary tract. J. med. Microbiol 12:1
    [Google Scholar]
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