1887

Abstract

SUMMARY

Sulphadiazine and trimethoprim in a wide range of concentrations were added to urine from patients with untreated urinary-tract infections. At therapeutic concentrations, the antibacterial activity of trimethoprim was not increased by the addition of sulphadiazine. Exposure of to trimethoprim in urine was not associated with an increase in resistance to that agent. It was also not possible to select, , stable resistance to trimethoprim in sensitive cultures of .

At therapeutic levels in blood, trimethoprim and sulphadiazine singly produced mainly a bactericidal action on pathogens responsible for urinary-tract infections. Sulphadiazine occasionally enhanced the effect of trimethoprim at subtherapeutic levels. These findings support the need for further evaluation of trimethoprim alone, rather than its use as a combination with a sulphonamide.

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1980-02-01
2022-01-26
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References

  1. Acar J. F., Goldstein F. W., Gerbaud G. R., Chabbert Y. A. 1977; Plasmides de résistance au triméthoprime: transferabilité et groupes d’incompatabilité. Annals Microbiol. 128A:41
    [Google Scholar]
  2. Aizenberg O. A., Samoylenko I. I., Fradkin G. E. 1977; Role of the B+ gene product in thymineless death and characteristics of this phenomenon in a thyrecBmutant of Escherichia coli K-12. Genetika 13:1988
    [Google Scholar]
  3. Amyes S. G. B., Smith J. T. 1978; Trimethoprim antagonists: effect of uridine on thymine and thymidine uptake in mineral salt medium. J. antimicrob. Chemother 4:415
    [Google Scholar]
  4. Anderson J. D., Lacey R. W., Lewis E. L., Sellin M. A. 1974; Failure to demonstrate an advantage in combining sulphamethoxazole with trimethoprim in an experimental model of urinary infection. J. clin. Path 27:619
    [Google Scholar]
  5. Brumfitt W., Pursell R. 1972; Double-blind trial to compare ampicillin, cephalexin, co-trimoxazole and trimethoprim in treatment or urinary infection. Br. med. J 2:673
    [Google Scholar]
  6. Buick R. N., Harris W. J. 1975; Thymineless death in Bacillus subtilis. J. gen. Microbiol 88:115
    [Google Scholar]
  7. Greenwood D., O’Grady F. 1976; Activity and interaction of trimethoprim and sulphamethoxazole against. Escherichia coli. J. clin. Path 29:162
    [Google Scholar]
  8. Grey D., Hamilton-Miller J. M. T. 1977; Sensitivity of Pseudomonas aeruginosa to sulphonamides and trimethoprim and the activity of the combination trimethoprim: sulphamethoxazole. J. med. Microbiol 10:273
    [Google Scholar]
  9. Hitchings G. H. 1970; Trimethoprim: biochemical basis for sulphonamide potentiation. S. Afr. med. J., suppl 44:1
    [Google Scholar]
  10. Kasanen A., Kaarsalo E., Hiltunen R., Soini V. 1974; Comparison of long-term low dosage nitrofurantoin, methenamine hippurate, trimethoprim and trimethoprim-sulpha-methoxazole on the control of recurrent urinary-tract infection. Ann. clin. Res 6:285
    [Google Scholar]
  11. Koch U. J., Schumann K. P., Küchler R., Kewitz H. 1973; Efficacy of trimethoprim, sulphamethoxazole, and the combination of both in acute urinary tract infections: clinical and pharmacological studies. Chemotherapy 19:314
    [Google Scholar]
  12. Lacey R. W. 1978; The suppression of the appearance of bacterial mutants by combined antibacterial therapy. J. antimicrob. Chemother 4:391
    [Google Scholar]
  13. Lewis E. L., Anderson J. D., Lacey R. W. 1974; A reappraisal of the antibacterial action of cotrimoxazole in vitro. J. clin. Path 27:87
    [Google Scholar]
  14. Mӓnnistӧ P., Tuomisto J., Saris N-E., Lehtinen T. 1973; Pharmacokinetic studies with trimethoprim and different doses of sulphadiazine in healthy human subjects. Chemotherapy 19:289
    [Google Scholar]
  15. Nottebrock H., Then R. 1977; Thymidine concentrations in serum and urine of different animal species and man. Biochem. Pharmac 26:2175
    [Google Scholar]
  16. Pinney R. J., Jacob A. E., Hedges R. W., Smith J. T. 1977; Dislodgement and thymineless elimination of N-group plasmids. Gentet. Res 30:21
    [Google Scholar]
  17. Samanta H. K., Bhattacharjee S. B. 1977; Thymineless death in Escherichia coli. Z. Naturf 32:835
    [Google Scholar]
  18. Stokes A., Lacey R. W. 1978; Effect of thymidine on activity of trimethoprim and sulphamethoxazole. J. clin. Path 31:165
    [Google Scholar]
  19. Towner K. J., Pearson N. J., Cattell W. R., O’Grady F. 1978; Chromosomal resistance to trimethoprim. Lancet 1:1371
    [Google Scholar]
  20. Tuomisto J., Kasanen A., Renkonen O-V. 1977; Sulphadiazine-trimethoprim combinations in the treatment of urinary tract infections. Chemotherapy 23:337
    [Google Scholar]
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