Infant rabbits were shown to respond to heat-labile enterotoxin by a consistent increase in intestinal fluid content, which was maximal 5 h after oral dosing. Infant rabbits could be used in a simple quantitative assay for heat-labile enterotoxin based on the ratios of gut weight to remaining body weight 5 h after oral dosing. Infant rabbits remained responsive to heat-labile enterotoxin up to 14 days of age, after which their gastric H became low enough to destroy the enterotoxin. Rabbits that had been deprived of food before being dosed had a reduced gastric H and a reduced response to the enterotoxin.

Lincomycin and mitomycin C were found not to increase the yield of heat-labile enterotoxin from strain P307.


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