1887

Abstract

SUMMARY

Culture filtrates of micro-organisms isolated from the upper intestinal secretions of malnourished children and grown in pure culture were shown to impair the intestinal absorption of water and electrolytes in live rats. Decreased net movement out of the intestinal lumen, or actual secretion of water, sodium or potassium into the intestinal lumen, was found with culture filtrates of single isolates of 055, B7A, and These organisms have been found to contaminate upper intestinal secretions in malnourished children and it is suggested that the effects observed in these experiments might be relevant to the production of the diarrhoea that is a dominant clinical feature of childhood malnutrition.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-11-4-463
1978-11-01
2024-04-26
Loading full text...

Full text loading...

/deliver/fulltext/jmm/11/4/medmicro-11-4-463.html?itemId=/content/journal/jmm/10.1099/00222615-11-4-463&mimeType=html&fmt=ahah

References

  1. Banwell J. G. 1970; Intestinal fluid and electrolyte transport in human cholera. J. clin. Invest 49:183
    [Google Scholar]
  2. Burke V., Houghton M., Gracey M. 1977; Effect of enteric micro-organisms on intestinal sugar and fatty acid absorption. Aust. J. exp. Biol, med Sci 55:423
    [Google Scholar]
  3. Carpenter C. C. J., Greenough W. B. 1968; Response of the canine duodenum to intraluminal challenge with cholera exotoxin. J. clin. Invest 47:2600
    [Google Scholar]
  4. Duncan C. L., Strong D. H. 1969; Ileal loop fluid accumulation and production of diarrhea in rabbits by cell-free products of Clostridum perfringens. J. Bact 100:86
    [Google Scholar]
  5. Du Pont H. L., Formal S. B., Hornick R. B., Snyder M. J., Libonati J. P., Sheahan D. G., La Brec E. H., Kalas J. P. 1971; Pathogenesis of Escherichia coli diarrhea. N. Engl. J. Med 285:1
    [Google Scholar]
  6. Field M. 1971; Intestinal secretion: effect of cyclic AMP and its role in cholera. N. Engl. J. Med 284:1137
    [Google Scholar]
  7. Finkelstein R. A. 1976; Progress in the study of cholera and related enterotoxins. In Mechanisms of bacterial toxicology edited by Bemheimer A. W. New York: p 53
    [Google Scholar]
  8. Gracey M., Burke V., Thomas J. A., Stone D. E. 1975; Effect of micro-organisms isolated from the upper gut of malnourished children on intestinal sugar absorption in vivo. Am. J. clin. Nutr 28:841
    [Google Scholar]
  9. Gracey M., Suharjono Sunoto, Stone D. E. 1973; Microbial contamination of the gut: another feature of malnutrition. Am. J. clin. Nutr 26:1170
    [Google Scholar]
  10. Guerrant R. L., Ganguly U., Casper A. G. T., Moore E. J., Pierce N. F., Carpenter C. C. J. 1973; Effect of Escherichia coli on fluid transport across canine small bowel: mechanism and time-course with enterotoxin and whole bacterial cells. J. clin. Invest 52:1707
    [Google Scholar]
  11. Heyworth B., Brown J. 1975; Jejunal microflora in malnourished Gambian children. Archs Dis. Childh 50:27
    [Google Scholar]
  12. Keusch G. T., Jacewicz M. 1977; The pathogenesis of Shigella diarrhea. VI. Toxin and antitoxin in Shigella flexneri and Shigella sonnei infections in humans. J. infect. Dis 135:552
    [Google Scholar]
  13. Klipstein F. A., Holdeman L. V., Corcino J. J., Moore W. E. C. 1973; Enterotoxigenic bacteria in tropical sprue. Ann. intern. Med 79:632
    [Google Scholar]
  14. Leitch G. J., Iwert M. E., Burrows W. 1966; Experimental cholera in the rabbit ligated ileal loop: toxin induced water and ion movement. J. infect. Dis 116:303
    [Google Scholar]
  15. Mata L. J., Jimenez F., Cordon M., Rosales R., Prera E., Schneider R. E., Viteri F. 1972; Gastrointestinal flora of children with protein calorie malnutrition. Am. J. clin. Nutr 25:1118
    [Google Scholar]
  16. McGonagle T. J., Serebro H. A., Iber F. L., Bayless T. M., Hendrix T. R. 1969; Time of onset of action of cholera toxin in dog and rabbit. Gastroenterology 57:5
    [Google Scholar]
  17. Pierce N. F., Greenough W. B., Carpenter C. C. J. Jr 1971; Vibrio cholerae enterotoxin and its mode of action. Bact. Rev 35:1
    [Google Scholar]
  18. Pierce N. F., Wallace C. K. 1972; Stimulation of jejunal secretion by crude E. coli enterotoxin. Gastroenterology 63:439
    [Google Scholar]
  19. Rowland M. G. M., McCollum J. P. K. 1977; Malnutrition and gastroenteritis in The Gambia. Trans. R. Soc. trop. Med. Hyg 71:199
    [Google Scholar]
  20. Sussman M., Ryan C., Shields R. 1970; Effect of staphylococcal enterotoxin upon the intestinal handling of water and electrolytes. Br. J. Surg 57:391
    [Google Scholar]
  21. Swallow J. H., Code C. F., Freter R. 1968; Effect of cholera toxin on water and ion fluxes in the canine bowel. Gastroenterology 54:35
    [Google Scholar]
  22. Wadström T., Aust-Kettis A., Habte D., Holmgren J., Meeuwisse G., Mollby R., Soderlind O. 1976; Enterotoxin-producing bacteria and parasites in stools of Ethiopian children with diarrhoeal disease. Archs Dis. Childh 51:865
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-11-4-463
Loading
/content/journal/jmm/10.1099/00222615-11-4-463
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error