1887

Abstract

Summary

Porphyrin ring source appears to alter the outer membrane protein (OMP) profile of some, but not all, non-typable (NT) strains isolated from sputum. When haemin was replaced with protoporphyrin IX, 41% of strains examined produced increased amounts of a polypeptide of 84 Kda and new OMPs of either 120 or 150 Kda. Immunoblotting with paired patient's sera revealed that antibodies reactive with these proteins were present, demonstrating OMP antigenicity and expression and indicating that these isolates of NT may display an altered OMP phenotype when growing in the human lung.

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1990-03-01
2022-01-29
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