1887

Abstract

Although it has previously been shown that bovine parvovirus (BPV) attaches to the sialated glycoprotein glycophorin A on erythrocytes, the nature of virus-binding moieties on mammalian nucleated cells is less clear. Buffalo lung fibroblasts (Bu), primary bovine embryonic kidney cells, Madin–Darby bovine kidney cells and bovine embryonic trachea (EBTr) cells were assessed for molecules capable of binding BPV. Competition studies were carried out on both erythrocyte and nucleated cell targets using a variety of sialated compounds and sialic acid-negative compounds. Glycophorin A was found to inhibit BPV binding, while mucin exhibited low-level inhibition. These two sialated compounds also blocked attachment of BPV-modified microsphere carriers to the Bu cell membrane. Influenza A virus was used as a sialic acid competitor and interfered with BPV attachment to erythrocytes and replication in Bu cells. Significantly, the enzyme sialidase removed BPV-binding sites from Bu and EBTr cells. The binding sites could be reconstituted on sialidase-treated cells by the enzymes -2,3--sialyltransferase and -2,3--sialyltransferase. These results indicated that BPV can attach to sialic acid on cell membranes and that the sialylglycoproteins available for virus attachment appear to contain both - and -linked carbohydrate moieties, but that not all members of the sialic acid family can bind BPV. Moreover, there may be other moieties that can bind BPV, which may act as either primary or secondary receptors.

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2004-08-01
2024-12-06
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References

  1. Abinanti F. R., Warfield M. S. 1961; Recovery of a hemadsorbing virus (HADEN) from the gastrointestinal tract of calves. Virology 14:288–289 [CrossRef]
    [Google Scholar]
  2. Barbis D. P., Chang S.-F., Parrish C. R. 1992; Mutations adjacent to the dimple of the canine parvovirus capsid structure affect sialic acid binding. Virology 191:301–308 [CrossRef]
    [Google Scholar]
  3. Brown K. E., Anderson S. M., Young N. S. 1993; Erythrocyte P antigen: cellular receptor for B19 parvovirus. Science 262:114–117 [CrossRef]
    [Google Scholar]
  4. Challou N., Goormaghtigh E., Cabiaux V., Conrath K., Ruysschaert J.-M. 1994; Sequence and structure of the membrane-associated peptide of glycophorin A. Biochemistry 33:6902–6910 [CrossRef]
    [Google Scholar]
  5. Chen K. C., Shull B. C., Moses E. A., Lederman M., Stout E. R., Bates R. C. 1986; Complete nucleotide sequence and genome organization of bovine parvovirus. J Virol 60:1085–1097
    [Google Scholar]
  6. Chen K. C., Shull B. C., Lederman M., Stout E. R., Bates R. C. 1988; Analysis of the termini of the DNA of bovine parvovirus: demonstration of sequence inversion at the left terminus and its implication for the replication model. J Virol 62:3807–3813
    [Google Scholar]
  7. Fox J. M., Bloom M. E. 1999; Identification of a cell surface protein from Crandell feline kidney cells that specifically binds Aleutian mink disease parvovirus. J Virol 73:3835–3842
    [Google Scholar]
  8. Franca de Barros J. Jr, Sales Alviano D., da Silva M. H., Dutra Wigg M., Sales Alviano C., Schauer R., dos Santos Silva Couceiro J. N. 2003; Characterization of sialidase from an influenza A (H3N2) virus strain kinetic parameters and substrate specificity. Intervirology 46:199–206 [CrossRef]
    [Google Scholar]
  9. Furthmayr H., Marchesi V. T. 1976; Subunit structure of human erythrocyte glycophorin A. Biochemistry 15:1137–1144 [CrossRef]
    [Google Scholar]
  10. Goto H. 1975; Feline panleukopenia in Japan. II. Hemagglutinability of the isolated virus. Nippon Juigaku Zasshi 37:239–245 [CrossRef]
    [Google Scholar]
  11. Johnson F. B., Hoggan M. D. 1973; Structural proteins of HADEN virus. Virology 51:129–137 [CrossRef]
    [Google Scholar]
  12. Kaludov N., Brown K. E., Walters R. W., Zabner J., Chiorini J. A. 2001; Adeno-associated virus serotype 4 (AAV-4) and AAV-5 both require sialic acid binding for hemagglutination and efficient transduction but differ in sialic acid linkage specificity. J Virol 75:6884–6893 [CrossRef]
    [Google Scholar]
  13. Leary J. J., Storz J. 1980; Nucleopathic changes in parvovirus-infected, cultured cells. Exp Mol Pathol 32:188–200 [CrossRef]
    [Google Scholar]
  14. Luker G., Chow C., Richards D. F., Johnson F. B. 1991; Suitability of infection of cells in suspension for detection of herpes simplex virus. J Clin Microbiol 29:1554–1557
    [Google Scholar]
  15. Mochizuki M., Konishi S., Ogata M. 1978; Studies on feline panleukopenia. II. Antigenicities of the virus. Nippon Juigaku Zasshi 40:375–383 [CrossRef]
    [Google Scholar]
  16. Pritchard C., Stout E. R., Bates R. C. 1981; Replication of parvoviral DNA I. Characterization of a nuclear lysate system. J Virol 37:352–362
    [Google Scholar]
  17. Qing K., Mah C., Hansen J., Zhou S., Dwarki V., Srivastava A. 1999; Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2. Nat Med 5:71–77 [CrossRef]
    [Google Scholar]
  18. Qiu J., Handa A., Kirby M., Brown K. E. 2000; The interaction of heparin sulfate and adeno-associated virus 2. Virology 269:137–147 [CrossRef]
    [Google Scholar]
  19. Rogers G. N., Paulson J. C. 1983; Receptor determinants of human and animal influenza virus isolates: differences in receptor specificity of the H3 hemagglutinin based on species of origin. Virology 127:361–373 [CrossRef]
    [Google Scholar]
  20. Rogers G. N., Pritchett T. J., Lane J. L., Paulson J. C. 1983; Differential sensitivity of human, avian, and equine influenza A viruses to a glycoprotein inhibitor of infection: selection of receptor specific variants. Virology 131:394–408 [CrossRef]
    [Google Scholar]
  21. Spahn G. J., Mohanty S. B., Hetrick F. M. 1966; Experimental infection of calves with hemadsorbing enteric (HADEN) virus. Cornell Vet 56:377–386
    [Google Scholar]
  22. Summerford C., Samulski R. J. 1998; Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions. J Virol 72:1438–1445
    [Google Scholar]
  23. Summerford C., Bartlett J. S., Samulski R. J. 1999; α B β 5 integrin: a co-receptor for adeno-associated virus type 2 infection. Nat Med 5:78–82 [CrossRef]
    [Google Scholar]
  24. Thacker T. C., Johnson F. B. 1998; Binding of bovine parvovirus to erythrocyte membrane sialylglycoproteins. J Gen Virol 79:2163–2169
    [Google Scholar]
  25. Tomita M., Furthmayr H., Marchesi V. T. 1978; Primary structure of human erythrocyte glycophorin A. Isolation and characterization of peptides and complete amino acid sequence. Biochemistry 17:4756–4770 [CrossRef]
    [Google Scholar]
  26. Tullis G. E., Burger L. R., Pintel D. J. 1993; The minor capsid protein VP1 of the autonomous parvovirus minute virus of mice is dispensable for encapsidation of progeny single-stranded DNA but is required for infectivity. J Virol 67:131–141
    [Google Scholar]
  27. Walters R. W., Yi S. M. P., Keshavjee S., Brown K. E., Welsh M. J., Chiorini J. A., Zabner J. 2001; Binding of adeno-associated virus type 5 to 2,3-linked sialic acid is required for gene transfer. J Biol Chem 276:20610–20616 [CrossRef]
    [Google Scholar]
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