1887

Abstract

Recent studies have suggested an association between human papillomaviruses (HPVs), particularly species 2 members of the genus , and squamous cell carcinoma (SCC) of the skin. As most of these viruses are uncharacterized, molecular characterization and epidemiology are needed to advance our understanding of their significance in carcinogenesis. This study determined the complete genomes of four betapapillomaviruses of species 2 from skin lesions designated HPV-107, -110 and -111 and FA75[KI88-03], an isolate of an unpublished HPV type, and analysed their prevalence and viral loads in biopsies from SCC, actinic keratosis (AK), basal cell carcinoma, seborrhoeic keratosis and the healthy skin of 263 immunocompetent patients by HPV type-specific real-time PCR assays. Seventeen patients (6.5 %) harboured at least one of the four HPV types in their lesion, whereas seven patients (2.7 %) harboured one or more of the HPV types in healthy skin. Overall, the four viruses were more common in AK than in healthy skin (odds ratio 5.0, 95 % confidence interval 1.4–17.5), but the prevalence and viral loads were low. This characterization of HPV-107, -110 and -111 and FA75[KI88-03] expands the heterogeneity of members of species 2 of the genus . However, as these types were found in only a few samples and in low amounts, a possible role in carcinogenesis remains elusive.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.2008/001925-0
2008-10-01
2019-10-17
Loading full text...

Full text loading...

/deliver/fulltext/jgv/89/10/2467.html?itemId=/content/journal/jgv/10.1099/vir.0.2008/001925-0&mimeType=html&fmt=ahah

References

  1. Antonsson, A., Erfurt, C., Hazard, H., Holmgren, V., Simon, M., Kataoka, A., Hossin, S., Håkangård, C. & Hansson, B. G. ( 2003a; ). Prevalence and type spectrum of human papillomaviruses in healthy skin samples collected in three continents. J Gen Virol 84, 1881–1886.[CrossRef]
    [Google Scholar]
  2. Antonsson, A., Karanfilovska, S., Lindqvist, P. G. & Hansson, B. G. ( 2003b; ). General acquisition of human papillomavirus infections of skin occurs in early infancy. J Clin Microbiol 41, 2509–2514.[CrossRef]
    [Google Scholar]
  3. Asgari, M. M., Kiviat, N. B., Critchlow, C. W., Stern, J. E., Argenyi, Z. B., Raugi, G. J., Berg, D., Odland, P. B., Hawes, S. E. & de Villiers, E. M. ( 2008; ). Detection of human papillomavirus DNA in cutaneous squamous cell carcinoma among immunocompetent individuals. J Invest Dermatol 128, 1409–1417.[CrossRef]
    [Google Scholar]
  4. Astori, G., Lavergne, D., Benton, C., Hockmayr, B., Egawa, K., Garbe, C. & de Villiers, E. M. ( 1998; ). Human papillomaviruses are commonly found in normal skin of immunocompetent hosts. J Invest Dermatol 110, 752–755.[CrossRef]
    [Google Scholar]
  5. Bens, G., Wieland, U., Hofmann, A., Hopfl, R. & Pfister, H. ( 1998; ). Detection of new human papillomavirus sequences in skin lesions of a renal transplant recipient and characterization of one complete genome related to epidermodysplasia verruciformis-associated types. J Gen Virol 79, 779–787.
    [Google Scholar]
  6. Berkhout, R. J., Tieben, L. M., Smits, H. L., Bavinck, J. N., Vermeer, B. J. & ter Schegget, J. ( 1995; ). Nested PCR approach for detection and typing of epidermodysplasia verruciformis-associated human papillomavirus types in cutaneous cancers from renal transplant recipients. J Clin Microbiol 33, 690–695.
    [Google Scholar]
  7. Boukamp, P. ( 2005; ). Non-melanoma skin cancer: what drives tumor development and progression? Carcinogenesis 26, 1657–1667.[CrossRef]
    [Google Scholar]
  8. Boxman, I. L., Russell, A., Mulder, L. H., Bavinck, J. N., ter Schegget, J. & Green, A. ( 2001; ). Association between epidermodysplasia verruciformis-associated human papillomavirus DNA in plucked eyebrow hair and solar keratoses. J Invest Dermatol 117, 1108–1112.[CrossRef]
    [Google Scholar]
  9. Cazzaniga, M., Gheit, T., Casadio, C., Khan, N., Macis, D., Valenti, F., Miller, M. J., Sylla, B. S., Akiba, S. & other authors ( 2008; ). Analysis of the presence of cutaneous and mucosal papillomavirus types in ductal lavage fluid, milk and colostrum to evaluate its role in breast carcinogenesis. Breast Cancer Res TreatMay 9; Epub ahead of print) doi:10.1007/s10549-008-0040-3.
    [Google Scholar]
  10. Chambers, G., Ellsmore, V. A., O'Brien, P. M., Reid, S. W., Love, S., Campo, M. S. & Nasir, L. ( 2003; ). Association of bovine papillomavirus with the equine sarcoid. J Gen Virol 84, 1055–1062.[CrossRef]
    [Google Scholar]
  11. de Villiers, E. M., Fauquet, C., Broker, T. R., Bernard, H. U. & zur Hausen, H. ( 2004; ). Classification of papillomaviruses. Virology 324, 17–27.[CrossRef]
    [Google Scholar]
  12. Doorbar, J. ( 2005; ). The papillomavirus life cycle. J Clin Virol 32 (Suppl. 1), S7–S15.
    [Google Scholar]
  13. Forslund, O. ( 2007; ). Genetic diversity of cutaneous human papillomaviruses. J Gen Virol 88, 2662–2669.[CrossRef]
    [Google Scholar]
  14. Forslund, O., Antonsson, A., Nordin, P., Stenquist, B. & Hansson, B. G. ( 1999; ). A broad range of human papillomavirus types detected with a general PCR method suitable for analysis of cutaneous tumours and normal skin. J Gen Virol 80, 2437–2443.
    [Google Scholar]
  15. Forslund, O., Ly, H., Reid, C. & Higgins, G. ( 2003; ). A broad spectrum of human papillomavirus types is present in the skin of Australian patients with non-melanoma skin cancers and solar keratosis. Br J Dermatol 149, 64–73.[CrossRef]
    [Google Scholar]
  16. Forslund, O., Lindelof, B., Hradil, E., Nordin, P., Stenquist, B., Kirnbauer, R., Slupetzky, K. & Dillner, J. ( 2004; ). High prevalence of cutaneous human papillomavirus DNA on the top of skin tumors but not in “stripped” biopsies from the same tumors. J Invest Dermatol 123, 388–394.[CrossRef]
    [Google Scholar]
  17. Forslund, O., Iftner, T., Andersson, K., Lindelof, B., Hradil, E., Nordin, P., Stenquist, B., Kirnbauer, R., Dillner, J. & de Villiers, E. M. ( 2007; ). Cutaneous human papillomaviruses found in sun-exposed skin: beta-papillomavirus species 2 predominates in squamous cell carcinoma. J Infect Dis 196, 876–883.[CrossRef]
    [Google Scholar]
  18. Hall, T. A. ( 1999; ). BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucleic Acids Symp Ser 41, 95–98.
    [Google Scholar]
  19. Harwood, C. A. & Proby, C. M. ( 2002; ). Human papillomaviruses and non-melanoma skin cancer. Curr Opin Infect Dis 15, 101–114.[CrossRef]
    [Google Scholar]
  20. Hazard, K., Eliasson, L., Dillner, J. & Forslund, O. ( 2006; ). Subtype HPV38b[FA125] demonstrates heterogeneity of human papillomavirus type 38. Int J Cancer 119, 1073–1077.[CrossRef]
    [Google Scholar]
  21. Jablonska, S. & Majewski, S. ( 1994; ). Epidermodysplasia verruciformis: immunological and clinical aspects. Curr Top Microbiol Immunol 186, 157–175.
    [Google Scholar]
  22. Jackson, S., Harwood, C., Thomas, M., Banks, L. & Storey, A. ( 2000; ). Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins. Genes Dev 14, 3065–3073.[CrossRef]
    [Google Scholar]
  23. Kremsdorf, D., Favre, M., Jablonska, S., Obalek, S., Rueda, L. A., Lutzner, M. A., Blanchet-Bardon, C., van Voorst Vader, P. C. & Orth, G. ( 1984; ). Molecular cloning and characterization of the genomes of nine newly recognized human papillomavirus types associated with epidermodysplasia verruciformis. J Virol 52, 1013–1018.
    [Google Scholar]
  24. Kullander, J., Handisurya, A., Forslund, O., Geusau, A., Kirnbauer, R. & Dillner, J. ( 2008; ). Cutaneous human papillomavirus 88: remarkable differences in viral load. Int J Cancer 122, 477–480.[CrossRef]
    [Google Scholar]
  25. Martens, A., De Moor, A. & Ducatelle, R. ( 2001; ). PCR detection of bovine papilloma virus DNA in superficial swabs and scrapings from equine sarcoids. Vet J 161, 280–286.[CrossRef]
    [Google Scholar]
  26. Meyer, T., Arndt, R., Christophers, E., Nindl, I. & Stockfleth, E. ( 2001; ). Importance of human papillomaviruses for the development of skin cancer. Cancer Detect Prev 25, 533–547.
    [Google Scholar]
  27. Oberyszyn, T. M. ( 2008; ). Non-melanoma skin cancer: importance of gender, immunosuppressive status and vitamin D. Cancer Lett 261, 127–136.[CrossRef]
    [Google Scholar]
  28. Orth, G., Jablonska, S., Favre, M., Croissant, O., Jarzabek Chorzelska, M. & Rzesa, G. ( 1978; ). Characterization of two types of human papillomaviruses in lesions of epidermodysplasia verruciformis. Proc Natl Acad Sci U S A 75, 1537–1541.[CrossRef]
    [Google Scholar]
  29. Pfister, H. ( 2003; ). Chapter 8. Human papillomavirus and skin cancer. J Natl Cancer Inst Monogr 52–56.
    [Google Scholar]
  30. Pfister, H. & Ter Schegget, J. ( 1997; ). Role of HPV in cutaneous premalignant and malignant tumors. Clin Dermatol 15, 335–347.[CrossRef]
    [Google Scholar]
  31. Pfister, H., Fuchs, P. G., Majewski, S., Jablonska, S., Pniewska, I. & Malejczyk, M. ( 2003; ). High prevalence of epidermodysplasia verruciformis-associated human papillomavirus DNA in actinic keratoses of the immunocompetent population. Arch Dermatol Res 295, 273–279.[CrossRef]
    [Google Scholar]
  32. Preston, D. S. & Stern, R. S. ( 1992; ). Nonmelanoma cancers of the skin. N Engl J Med 327, 1649–1662.[CrossRef]
    [Google Scholar]
  33. Radulescu, R. T., Bellitti, M. R., Ruvo, M., Cassani, G. & Fassina, G. ( 1995; ). Binding of the LXCXE insulin motif to a hexapeptide derived from retinoblastoma protein. Biochem Biophys Res Commun 206, 97–102.[CrossRef]
    [Google Scholar]
  34. Ramos, J., Villa, J., Ruiz, A., Armstrong, R. & Matta, J. ( 2004; ). UV dose determines key characteristics of nonmelanoma skin cancer. Cancer Epidemiol Biomarkers Prev 13, 2006–2011.
    [Google Scholar]
  35. Reichrath, J. ( 2006; ). The challenge resulting from positive and negative effects of sunlight: how much solar UV exposure is appropriate to balance between risks of vitamin D deficiency and skin cancer? Prog Biophys Mol Biol 92, 9–16.[CrossRef]
    [Google Scholar]
  36. Shadan, F. F. & Villarreal, L. P. ( 1993; ). Coevolution of persistently infecting small DNA viruses and their hosts linked to host-interactive regulatory domains. Proc Natl Acad Sci U S A 90, 4117–4121.[CrossRef]
    [Google Scholar]
  37. Shamanin, V., Glover, M., Rausch, C., Proby, C., Leigh, I. M., zur Hausen, H. & de Villiers, E. M. ( 1994; ). Specific types of human papillomavirus found in benign proliferations and carcinomas of the skin in immunosuppressed patients. Cancer Res 54, 4610–4613.
    [Google Scholar]
  38. Stern, R. S. ( 1999; ). The mysteries of geographic variability in nonmelanoma skin cancer incidence. Arch Dermatol 135, 843–844.
    [Google Scholar]
  39. Tamura, K., Dudley, J., Nei, M. & Kumar, S. ( 2007; ). mega4: molecular evolutionary genetics analysis (mega) software version 4.0. Mol Biol Evol 24, 1596–1599.[CrossRef]
    [Google Scholar]
  40. Ullman, C. G., Haris, P. I., Galloway, D. A., Emery, V. C. & Perkins, S. J. ( 1996; ). Predicted α-helix/β-sheet secondary structures for the zinc-binding motifs of human papillomavirus E7 and E6 proteins by consensus prediction averaging and spectroscopic studies of E7. Biochem J 319, 229–239.
    [Google Scholar]
  41. Weissenborn, S. J., Nindl, I., Purdie, K., Harwood, C., Proby, C., Breuer, J., Majewski, S., Pfister, H. & Wieland, U. ( 2005; ). Human papillomavirus-DNA loads in actinic keratoses exceed those in non-melanoma skin cancers. J Invest Dermatol 125, 93–97.[CrossRef]
    [Google Scholar]
  42. Wilson, V. G., West, M., Woytek, K. & Rangasamy, D. ( 2002; ). Papillomavirus E1 proteins: form, function, and features. Virus Genes 24, 275–290.[CrossRef]
    [Google Scholar]
  43. Woodman, C. B., Collins, S. I. & Young, L. S. ( 2007; ). The natural history of cervical HPV infection: unresolved issues. Nat Rev Cancer 7, 11–22.[CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.2008/001925-0
Loading
/content/journal/jgv/10.1099/vir.0.2008/001925-0
Loading

Data & Media loading...

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error