1887

Abstract

Malignant catarrhal fever (MCF) is a herpesvirus disease syndrome of ruminants. The microscopic pathology of MCF is characterized by lymphoid proliferation and infiltration, necrotizing vasculitis and epithelial necrosis. Because previous attempts to detect viral antigen or nucleic acids in lesions have been unsuccessful, the pathogenesis of the lesions in acute MCF has been speculated to involve mechanisms of autoimmunity and lymphocyte dysregulation. In this study, the vascular lesions in the brains of a cow and a bison with acute MCF were evaluated by PCR and immunohistochemistry. The results demonstrated that the predominant infiltrating cell type in these lesions was CD8 T lymphocytes and that large numbers of these cells were infected with ovine herpesvirus 2. The lesions also contained macrophages, but no detectable CD4 or B lymphocytes.

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2003-08-01
2021-03-08
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References

  1. Bridgen A., Munro R., Reid H. W.. 1992; The detection of alcelaphine herpesvirus-1 DNA by in situ hybridization of tissues from rabbits affected with malignant catarrhal fever. J Comp Pathol106:351–359
    [Google Scholar]
  2. Burrells C., Reid H. W.. 1991; Phenotypic analysis of lymphoblastoid cell lines derived from cattle and deer affected with ‘sheep-associated’ malignant catarrhal fever. Vet Immunol Immunopathol29:151–161
    [Google Scholar]
  3. Buxton D., Reid H. W., Finlayson J., Pow I.. 1984; Pathogenesis of ‘sheep-associated’ malignant catarrhal fever in rabbits. Res Vet Sci36:205–211
    [Google Scholar]
  4. Cook C. G., Splitter G. A.. 1988; Lytic function of bovine lymphokine-activated killer cells from a normal and a malignant catarrhal fever virus-infected animal. Vet Immunol Immunopathol19:105–118
    [Google Scholar]
  5. Crawford T., O'Toole D. T., Li H.. 1999a; Malignant catarrhal fever. In Current Veterinary Therapy 4: Food Animal Practice . pp 306–309 Edited by Howell J., Smith R. A.. Oklahoma City: W. B. Saunders Company;
  6. Crawford T. B., Li H., O'Toole D. T., Li H.. 1999b; Diagnosis of malignant catarrhal fever by PCR using formalin-fixed, paraffin-embedded tissues. J Vet Diagn Invest11:111–116
    [Google Scholar]
  7. Edington N., Patel J., Russell P. H., Plowright W.. 1979; The nature of the acute lymphoid proliferation in rabbits infected with the herpes virus of bovine malignant catarrhal fever. Eur J Cancer15:1515–1522
    [Google Scholar]
  8. Ellis J. A., O'Toole D. T., Haven T. R., Davis W. C.. 1992; Predominance of BoCD8-positive T lymphocytes in vascular lesions in a 1-year-old cow with concurrent malignant catarrhal fever and bovine viral diarrhea virus infection. Vet Pathol29:545–547
    [Google Scholar]
  9. Innes J. R. M., Saunders L. Z.. 1962; Viral and rickettsial encephalopathies. In Comparative Neuropathology pp 415–417 New York: Academic Press;
    [Google Scholar]
  10. Kalunda M., Dardiri A. H., Lee K. M.. 1981; Malignant catarrhal fever. I. Response of American cattle to malignant catarrhal virus isolated in Kenya. Can J Comp Med45:70–76
    [Google Scholar]
  11. Lagourette P., Delverdier M., Bourges A. N., Amardeilh M. F., Schelcher F., Cabanie P., Espinasse J.. 1997; Immunohistochemical study of lymphoid cell reactions in four cattle affected with malignant catarrhal fever. Eur J Vet Pathol3:73–78
    [Google Scholar]
  12. Li H., Shen D. T., O'Toole D. T., Knowles D. P., Gorham J. R., Crawford T. B.. 1995; Investigation of sheep-associated malignant catarrhal fever virus infection in ruminants by PCR and competitive inhibition enzyme-linked immunosorbent assay. J Clin Microbiol33:2048–2053
    [Google Scholar]
  13. Li H., McGuire T. C., Muller-Doblies U. U., Crawford T. B.. 2001; A simpler, more sensitive competitive inhibition ELISA for detection of antibody to malignant catarrhal fever viruses. J Vet Diagn Invest13:361–364
    [Google Scholar]
  14. MacHugh N. D., Mburu J. K., Carol M. J., Wyatt C. R., Orden J. A., Davis W. C.. 1997; Identification of two distinct subsets of bovine gamma delta T cells with unique cell surface phenotype and tissue distribution. Immunology92:340–345
    [Google Scholar]
  15. Nakajima Y., Momotani E., Ishikawa Y., Murakami T., Shimura N., Onuma M.. 1992; Phenotyping of lymphocyte subsets in the vascular and epithelial lesions of a cow with malignant catarrhal fever. Vet Immunol Immunopathol33:279–284
    [Google Scholar]
  16. Nakajima Y., Ishikawa Y., Kadota K., Kodama M., Honma Y.. 1994; Surface marker analysis of the vascular and epithelia lesions in cattle with sheep-associated malignant catarrhal fever. J Vet Med Sci56:1065–1068
    [Google Scholar]
  17. Piercy S. E.. 1952a; Studies in bovine malignant catarrh. II. Experimental infection of cattle (contd.). (i) Infectivity of materials other than lymph glands. (ii) Routes of inoculation. Br Vet J108:214–220
    [Google Scholar]
  18. Piercy S. E.. 1952b; Studies in malignant catarrh. I. Experimental infection in cattle. Br Vet J108:35–47
    [Google Scholar]
  19. Pierson R. E., Hamdy F. M., Dardiri A. H., Ferris D. H., Schloer G. M.. 1979; Comparison of African and American forms of malignant catarrhal fever: transmission and clinical signs. Am J Vet Res40:1091–1095
    [Google Scholar]
  20. Plowright W.. 1965; Malignant catarrhal fever in East Africa. Res Vet Sci6:57–83
    [Google Scholar]
  21. Plowright W.. 1968; Malignant catarrhal fever. J Am Vet Med Assoc152:795–806
    [Google Scholar]
  22. Plowright W.. 1990; Malignant catarrhal fever virus. In Virus Infections of Ruminants pp 123–150 Edited by Dinter Z., Morein B.. New York: Elsevier Science;
    [Google Scholar]
  23. Reid H. W., Buxton D.. 1984; Malignant catarrhal fever of deer. Proc R Soc Edinburgh82B:261–273
    [Google Scholar]
  24. Rossiter P. B.. 1980; A lack of readily demonstrable virus antigens in the tissues of rabbits and cattle infected with malignant catarrhal fever virus. Br Vet J136:478–483
    [Google Scholar]
  25. Rossiter P. B.. 1985; Immunology and immunopathology of malignant catarrhal fever. Prog Vet Microbiol Immunol1:121–144
    [Google Scholar]
  26. Schock A., Reid H. W.. 1996; Characterisation of the lymphoproliferation in rabbits experimentally affected with malignant catarrhal fever. Vet Microbiol53:111–119
    [Google Scholar]
  27. Schock A., Collins R. A., Reid H. W.. 1998; Phenotype, growth regulation and cytokine transcription in ovine herpesvirus-2 (OHV-2)-infected bovine T-cell lines. Vet Immunol Immunopathol66:67–81
    [Google Scholar]
  28. Summers B. A., Cummings J. F., de Lahunta A.. 1995; Inflammatory diseases of the central nervous system. In Veterinary Neuropathology pp 142–143 St Louis: Mosby;
    [Google Scholar]
  29. Swa S., Wright H., Thomson J., Reid H., Haig D.. 2001; Constitutive activation of Lck and Fyn tyrosine kinases in large granular lymphocytes infected with the gamma-herpesvirus agents of malignant catarrhal fever. Immunology102:44–52
    [Google Scholar]
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