1887

Abstract

Malignant catarrhal fever (MCF) is a herpesvirus disease syndrome of ruminants. The microscopic pathology of MCF is characterized by lymphoid proliferation and infiltration, necrotizing vasculitis and epithelial necrosis. Because previous attempts to detect viral antigen or nucleic acids in lesions have been unsuccessful, the pathogenesis of the lesions in acute MCF has been speculated to involve mechanisms of autoimmunity and lymphocyte dysregulation. In this study, the vascular lesions in the brains of a cow and a bison with acute MCF were evaluated by PCR and immunohistochemistry. The results demonstrated that the predominant infiltrating cell type in these lesions was CD8 T lymphocytes and that large numbers of these cells were infected with ovine herpesvirus 2. The lesions also contained macrophages, but no detectable CD4 or B lymphocytes.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.19048-0
2003-08-01
2020-01-26
Loading full text...

Full text loading...

/deliver/fulltext/jgv/84/8/vir842009.html?itemId=/content/journal/jgv/10.1099/vir.0.19048-0&mimeType=html&fmt=ahah

References

  1. Bridgen, A., Munro, R. & Reid, H. W. ( 1992; ). The detection of alcelaphine herpesvirus-1 DNA by in situ hybridization of tissues from rabbits affected with malignant catarrhal fever. J Comp Pathol 106, 351–359.[CrossRef]
    [Google Scholar]
  2. Burrells, C. & Reid, H. W. ( 1991; ). Phenotypic analysis of lymphoblastoid cell lines derived from cattle and deer affected with ‘sheep-associated’ malignant catarrhal fever. Vet Immunol Immunopathol 29, 151–161.[CrossRef]
    [Google Scholar]
  3. Buxton, D., Reid, H. W., Finlayson, J. & Pow, I. ( 1984; ). Pathogenesis of ‘sheep-associated’ malignant catarrhal fever in rabbits. Res Vet Sci 36, 205–211.
    [Google Scholar]
  4. Cook, C. G. & Splitter, G. A. ( 1988; ). Lytic function of bovine lymphokine-activated killer cells from a normal and a malignant catarrhal fever virus-infected animal. Vet Immunol Immunopathol 19, 105–118.[CrossRef]
    [Google Scholar]
  5. Crawford, T., O'Toole, D. T. & Li, H. ( 1999a; ). Malignant catarrhal fever. In Current Veterinary Therapy 4: Food Animal Practice, pp. 306–309. Edited by J. Howell & R. A. Smith. Oklahoma City: W. B. Saunders Company.
  6. Crawford, T. B., Li, H., O'Toole, D. T. & Li, H. ( 1999b; ). Diagnosis of malignant catarrhal fever by PCR using formalin-fixed, paraffin-embedded tissues. J Vet Diagn Invest 11, 111–116.[CrossRef]
    [Google Scholar]
  7. Edington, N., Patel, J., Russell, P. H. & Plowright, W. ( 1979; ). The nature of the acute lymphoid proliferation in rabbits infected with the herpes virus of bovine malignant catarrhal fever. Eur J Cancer 15, 1515–1522.[CrossRef]
    [Google Scholar]
  8. Ellis, J. A., O'Toole, D. T., Haven, T. R. & Davis, W. C. ( 1992; ). Predominance of BoCD8-positive T lymphocytes in vascular lesions in a 1-year-old cow with concurrent malignant catarrhal fever and bovine viral diarrhea virus infection. Vet Pathol 29, 545–547.[CrossRef]
    [Google Scholar]
  9. Innes, J. R. M. & Saunders, L. Z. ( 1962; ). Viral and rickettsial encephalopathies. In Comparative Neuropathology, pp. 415–417. New York: Academic Press.
  10. Kalunda, M., Dardiri, A. H. & Lee, K. M. ( 1981; ). Malignant catarrhal fever. I. Response of American cattle to malignant catarrhal virus isolated in Kenya. Can J Comp Med 45, 70–76.
    [Google Scholar]
  11. Lagourette, P., Delverdier, M., Bourges, A. N., Amardeilh, M. F., Schelcher, F., Cabanie, P. & Espinasse, J. ( 1997; ). Immunohistochemical study of lymphoid cell reactions in four cattle affected with malignant catarrhal fever. Eur J Vet Pathol 3, 73–78.
    [Google Scholar]
  12. Li, H., Shen, D. T., O'Toole, D. T., Knowles, D. P., Gorham, J. R. & Crawford, T. B. ( 1995; ). Investigation of sheep-associated malignant catarrhal fever virus infection in ruminants by PCR and competitive inhibition enzyme-linked immunosorbent assay. J Clin Microbiol 33, 2048–2053.
    [Google Scholar]
  13. Li, H., McGuire, T. C., Muller-Doblies, U. U. & Crawford, T. B. ( 2001; ). A simpler, more sensitive competitive inhibition ELISA for detection of antibody to malignant catarrhal fever viruses. J Vet Diagn Invest 13, 361–364.[CrossRef]
    [Google Scholar]
  14. MacHugh, N. D., Mburu, J. K., Carol, M. J., Wyatt, C. R., Orden, J. A. & Davis, W. C. ( 1997; ). Identification of two distinct subsets of bovine gamma delta T cells with unique cell surface phenotype and tissue distribution. Immunology 92, 340–345.[CrossRef]
    [Google Scholar]
  15. Nakajima, Y., Momotani, E., Ishikawa, Y., Murakami, T., Shimura, N. & Onuma, M. ( 1992; ). Phenotyping of lymphocyte subsets in the vascular and epithelial lesions of a cow with malignant catarrhal fever. Vet Immunol Immunopathol 33, 279–284.[CrossRef]
    [Google Scholar]
  16. Nakajima, Y., Ishikawa, Y., Kadota, K., Kodama, M. & Honma, Y. ( 1994; ). Surface marker analysis of the vascular and epithelia lesions in cattle with sheep-associated malignant catarrhal fever. J Vet Med Sci 56, 1065–1068.[CrossRef]
    [Google Scholar]
  17. Piercy, S. E. ( 1952a; ). Studies in bovine malignant catarrh. II. Experimental infection of cattle (contd.). (i) Infectivity of materials other than lymph glands. (ii) Routes of inoculation. Br Vet J 108, 214–220.
    [Google Scholar]
  18. Piercy, S. E. ( 1952b; ). Studies in malignant catarrh. I. Experimental infection in cattle. Br Vet J 108, 35–47.
    [Google Scholar]
  19. Pierson, R. E., Hamdy, F. M., Dardiri, A. H., Ferris, D. H. & Schloer, G. M. ( 1979; ). Comparison of African and American forms of malignant catarrhal fever: transmission and clinical signs. Am J Vet Res 40, 1091–1095.
    [Google Scholar]
  20. Plowright, W. ( 1965; ). Malignant catarrhal fever in East Africa. Res Vet Sci 6, 57–83.
    [Google Scholar]
  21. Plowright, W. ( 1968; ). Malignant catarrhal fever. J Am Vet Med Assoc 152, 795–806.
    [Google Scholar]
  22. Plowright, W. ( 1990; ). Malignant catarrhal fever virus. In Virus Infections of Ruminants, pp. 123–150. Edited by Z. Dinter & B. Morein. New York: Elsevier Science.
  23. Reid, H. W. & Buxton, D. ( 1984; ). Malignant catarrhal fever of deer. Proc R Soc Edinburgh 82B, 261–273.
    [Google Scholar]
  24. Rossiter, P. B. ( 1980; ). A lack of readily demonstrable virus antigens in the tissues of rabbits and cattle infected with malignant catarrhal fever virus. Br Vet J 136, 478–483.
    [Google Scholar]
  25. Rossiter, P. B. ( 1985; ). Immunology and immunopathology of malignant catarrhal fever. Prog Vet Microbiol Immunol 1, 121–144.
    [Google Scholar]
  26. Schock, A. & Reid, H. W. ( 1996; ). Characterisation of the lymphoproliferation in rabbits experimentally affected with malignant catarrhal fever. Vet Microbiol 53, 111–119.[CrossRef]
    [Google Scholar]
  27. Schock, A., Collins, R. A. & Reid, H. W. ( 1998; ). Phenotype, growth regulation and cytokine transcription in ovine herpesvirus-2 (OHV-2)-infected bovine T-cell lines. Vet Immunol Immunopathol 66, 67–81.[CrossRef]
    [Google Scholar]
  28. Summers, B. A., Cummings, J. F. & de Lahunta, A. ( 1995; ). Inflammatory diseases of the central nervous system. In Veterinary Neuropathology, pp. 142–143. St Louis: Mosby.
  29. Swa, S., Wright, H., Thomson, J., Reid, H. & Haig, D. ( 2001; ). Constitutive activation of Lck and Fyn tyrosine kinases in large granular lymphocytes infected with the gamma-herpesvirus agents of malignant catarrhal fever. Immunology 102, 44–52.[CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.19048-0
Loading
/content/journal/jgv/10.1099/vir.0.19048-0
Loading

Data & Media loading...

Most cited articles

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error