RT Journal Article SR Electronic(1) A1 Simon, Susan A1 Li, Hong A1 O'Toole, Donal A1 Crawford, Timothy B. A1 Oaks, J. LindsayYR 2003 T1 The vascular lesions of a cow and bison with sheep-associated malignant catarrhal fever contain ovine herpesvirus 2-infected CD8+ T lymphocytes JF Journal of General Virology, VO 84 IS 8 SP 2009 OP 2013 DO https://doi.org/10.1099/vir.0.19048-0 PB Microbiology Society, SN 1465-2099, AB Malignant catarrhal fever (MCF) is a herpesvirus disease syndrome of ruminants. The microscopic pathology of MCF is characterized by lymphoid proliferation and infiltration, necrotizing vasculitis and epithelial necrosis. Because previous attempts to detect viral antigen or nucleic acids in lesions have been unsuccessful, the pathogenesis of the lesions in acute MCF has been speculated to involve mechanisms of autoimmunity and lymphocyte dysregulation. In this study, the vascular lesions in the brains of a cow and a bison with acute MCF were evaluated by in situ PCR and immunohistochemistry. The results demonstrated that the predominant infiltrating cell type in these lesions was CD8+ T lymphocytes and that large numbers of these cells were infected with ovine herpesvirus 2. The lesions also contained macrophages, but no detectable CD4+ or B lymphocytes., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.19048-0