1887

Abstract

A survey of wild-rodent populations has revealed that murine norovirus (MNV) is present and diverse in wild-house mice . This virus is genetically similar to MNV infecting show mice and previously described variants circulating in laboratory mice. The detection of MNV in wild-mouse populations suggests that MNV infection of laboratory mice and show mice (from which laboratory mice are derived) derives from contact with or their origins from wild-mouse progenitors. The survey additionally identified frequent infection of wood mice ( with genetically divergent variants of MNV. These viruses are distinct from previously described MNV variants, differing by 22–23 % over the complete genome sequence compared with a maximum of 13 % between derived strains. Comparison with other noroviruses reveals that the MNV groups with MNV in genogroup V and shares the same overall genome organization, predicted lengths of proteins encoded by ORFs 1–3 and the existence of a conserved alternative reading frame in VP1 encoding a homologue of the MNV ORF4. Different MNV isolates were as variable as MNV isolates and showed evidence for inter-isolate recombination. Our observation of species-specific associations of MNV variants in wild populations suggests that murine noroviruses have an ancient origin, a feature that they may share with other norovirus genogroups.

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2012-02-01
2019-12-11
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