Skip to content
1887

Journal of General Virology header logo Journal of General Virology

Volume 92, Issue 8

Human papillomavirus infection in nasal polyps in a Chinese population No Access

Abstract

In order to determine the prevalence and genotype distribution of human papillomavirus (HPV) infection in patients with nasal polyps, a total of 204 patients with nasal polyps and 36 healthy controls were recruited for this study. Genomic DNA was extracted from paraffin-embedded tissue sections. HPV DNA genotyping was achieved by a flow-through hybridization and gene-chip method. HPV-positive infection was identified in 82 of 204 (40.2 %) patients, while HPV DNA was not found in healthy controls (<0.05). Genotyping analysis showed that low-risk HPV genotype 11 was the most prevalent type of HPV in nasal polyps (45.28 %). Both single and multiple HPV genotype infections were found in these HPV-positive cases, although most (74.39 %) were infected with a single genotype. In addition, there was no correlation between HPV infection or HPV subtypes and the clinicopathological characteristics of patients, such as age, gender, number of surgery and disease course. The data from our study clearly demonstrated that HPV infection was associated with nasal polyps. Both high-risk HPV and low-risk HPV (LR-HPV) genotypes were identified in nasal polyp tissues, and LR-HPV-11 was the most prevalent type. Future research will explore the association of HPV infection with the development and progression of nasal polyps.

  • Received:
  • Accepted:
  • Published Online:
© 2011 SGM
Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.031955-0
2011-08-01
2025-03-25
Loading full text...

Full text loading...

References

  1. Bo X., Yan T., Hou-zhao W. 2010; Application of flow-through and hybridization gene chip technology on detection of human papilloma virus. Occup Health (Lond) 26:1910–1911
     [Google Scholar]
  2. Castle P. E., Schiffman M., Herrero R., Hildesheim A., Rodriguez A. C., Bratti M. C., Sherman M. E., Wacholder S., Tarone R., Burk R. D. 2005; A prospective study of age trends in cervical human papillomavirus acquisition and persistence in Guanacaste, Costa Rica. J Infect Dis 191:1808–1816 [View Article][PubMed]
     [Google Scholar]
  3. Chow L. T., Nasseri M., Wolinsky S. M., Broker T. R. 1987; Human papillomavirus types 6 and 11 mRNAs from genital condylomata acuminata. J Virol 61:2581–2588[PubMed]
     [Google Scholar]
  4. De-you T., Xin L., Huang Z., Qu-xian O., Zi-yan P. 2009; Clinical analysis of HybriMax on human papillomavirus genotypes detection in 142 cases with Condyloma acuminate [J]. Southern China Journal of Dermato-Venereology 3:166
     [Google Scholar]
  5. Hamilos D. L., Leung D. Y., Wood R., Meyers A., Stephens J. K., Barkans J., Meng Q., Cunningham L., Bean D. K., Kay A. 1993; Chronic hyperplastic sinusitis: association of tissue eosinophilia with mRNA expression of granulocyte-macrophage colony-stimulating factor and interleukin-3. J Allergy Clin Immunol 92:39–48 [View Article][PubMed]
     [Google Scholar]
  6. Hedman J., Kaprio J., Poussa T., Nieminen M. M. 1999; Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study. Int J Epidemiol 28:717–722 [View Article][PubMed]
     [Google Scholar]
  7. Hoffmann M., Kahn T., Mahnke C. G., Goeroegh T., Lippert B. M., Werner J. A. 1998; Prevalence of human papillomavirus in squamous cell carcinoma of the head and neck determined by polymerase chain reaction and Southern blot hybridization: proposal for optimized diagnostic requirements. Acta Otolaryngol 118:138–144 [View Article][PubMed]
     [Google Scholar]
  8. Hoffmann M., Kahn T., Goeroegh T., Lohrey C., Gottschlich S., Meyer J., Rudert H., Maune S. 2000; Tracing human papillomavirus DNA in nasal polyps by polymerase chain reaction. Acta Otolaryngol 120:872–875 [View Article][PubMed]
     [Google Scholar]
  9. Hoffmann M., Klose N., Gottschlich S., Görögh T., Fazel A., Lohrey C., Rittgen W., Ambrosch P., Schwarz E., Kahn T. 2006; Detection of human papillomavirus DNA in benign and malignant sinonasal neoplasms. Cancer Lett 239:64–70 [View Article][PubMed]
     [Google Scholar]
  10. Huang S., Afonina I., Miller B. A., Beckmann A. M. 1997; Human papillomavirus types 52 and 58 are prevalent in cervical cancers from Chinese women. Int J Cancer 70:408–411 [View Article][PubMed]
     [Google Scholar]
  11. James M. A., Lee J. H., Klingelhutz A. J. 2006; Human papillomavirus type 16 E6 activates NF-κB, induces cIAP-2 expression, and protects against apoptosis in a PDZ binding motif-dependent manner. J Virol 80:5301–5307 [View Article][PubMed]
     [Google Scholar]
  12. Jin Q., Shen K., Li H., Zhou X. R., Huang H. F., Leng J. H., Zhang W. H., Gong X. M., Cheng X. M. et al. 2009; Prevalence of human papillomavirus infection in women in Tibet Autonomous Region of China. Zhonghua Fu Chan Ke Za Zhi 44:898–902 (in Chinese) [PubMed]
     [Google Scholar]
  13. Jing D., Yong-chang X., Xin-bo W. 2003; Expression of human papillomavirus DNA in nasal polyp. Chinese Journal of Otorhinolaryngology-skull Base Surgery 4:220–222
     [Google Scholar]
  14. Liu S. S., Leung R. C., Chan K. K., Cheung A. N., Ngan H. Y. 2010; Evaluation of a newly developed GenoArray human papillomavirus (HPV) genotyping assay and comparison with the Roche Linear Array HPV genotyping assay. J Clin Microbiol 48:758–764 [View Article][PubMed]
     [Google Scholar]
  15. Münger K., Baldwin A., Edwards K. M., Hayakawa H., Nguyen C. L., Owens M., Grace M., Huh K. 2004; Mechanisms of human papillomavirus-induced oncogenesis. J Virol 78:11451–11460 [View Article][PubMed]
     [Google Scholar]
  16. Mygind N. 1990; Nasal polyposis. J Allergy Clin Immunol 86:827–829 [View Article][PubMed]
     [Google Scholar]
  17. Newton J. R., Ah-See K. W. 2008; A review of nasal polyposis. Ther Clin Risk Manag 4:507–512[PubMed]
     [Google Scholar]
  18. Nguyen M. L., Nguyen M. M., Lee D., Griep A. E., Lambert P. F. 2003; The PDZ ligand domain of the human papillomavirus type 16 E6 protein is required for E6’s induction of epithelial hyperplasia in vivo. J Virol 77:6957–6964 [View Article][PubMed]
     [Google Scholar]
  19. Stierna P. L. 1996; Nasal polyps: relationship to infection and inflammation. Allergy Asthma Proc 17:251–257 [View Article][PubMed]
     [Google Scholar]
  20. Sun P., Chen X. P., Pei F., Ma R. X., Zhang Y., Chen Q., Dong W. G., Chen W. X., Huang H. L. 2010; Relationship between nasal inverted papilloma and human papillomavirus subtypes. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 45:310–313 (in Chinese) [PubMed]
     [Google Scholar]
  21. Suprynowicz F. A., Disbrow G. L., Krawczyk E., Simic V., Lantzky K., Schlegel R. 2008; HPV-16 E5 oncoprotein upregulates lipid raft components caveolin-1 and ganglioside GM1 at the plasma membrane of cervical cells. Oncogene 27:1071–1078 [View Article][PubMed]
     [Google Scholar]
  22. Tao P. P., Bian M. L., Ou H., Chen Q. Y., Li M., Liu J. 2006; Application research on the flow-through hybridization and gene chip in human papillomavirus detection. Zhonghua Fu Chan Ke Za Zhi 41:43–47 (in Chinese) [PubMed]
     [Google Scholar]
  23. Zaravinos A., Bizakis J., Spandidos D. A. 2009; Prevalence of human papilloma virus and human herpes virus types 1-7 in human nasal polyposis. J Med Virol 81:1613–1619 [View Article][PubMed]
     [Google Scholar]
  24. Zhou Y., Hu M., Liu C. 2001; Human papillomavirus DNA test in nasal polypsis. Lin Chuang Er Bi Yan Hou Ke Za Zhi 15:212–213 (in Chinese) [PubMed]
     [Google Scholar]
  25. zur Hausen H. 1996; Papillomavirus infections – a major cause of human cancers. Biochim Biophys Acta 1288:F55–F78[PubMed]
     [Google Scholar]
/content/journal/jgv/10.1099/vir.0.031955-0
Loading
Human papillomavirus infection in nasal polyps in a Chinese population
J. Gen. Virol. 92, 1795 (2011); https://doi.org/10.1099/vir.0.031955-0
/content/journal/jgv/10.1099/vir.0.031955-0
/content/journal/jgv/10.1099/vir.0.031955-0
Loading

Data & Media loading...

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error