1887

Abstract

A natural reassortant influenza A virus consisting of seven genome segments from pandemic (H1N1) 2009 virus and a neuraminidase segment from a Eurasian porcine H1N1 influenza A virus was detected in a pig herd in Germany. The obvious reassortment compatibility between the pandemic (H1N1) 2009 and H1N1 viruses of porcine origin raises concern as to whether swine may become a reservoir for further reassortants of pandemic (H1N1) 2009 viruses with unknown implications for human health and swine production.

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2011-05-01
2020-07-05
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References

  1. AVMA (2010). Public health, influenza, 2009 H1N1 flu virus. American Veterinary Medical Association http://www.avma.org/onlnews/javma/feb10/100201e.asp
  2. Brookes S. M., Núñez A., Choudhury B., Matrosovich M., Essen S. C., Clifford D., Slomka M. J., Kuntz-Simon G., Garcon F. et al. 2010; Replication, pathogenesis and transmission of pandemic (H1N1) 2009 virus in non-immune pigs. PLoS ONE 5:e9068 [CrossRef][PubMed]
    [Google Scholar]
  3. Ducatez M. F., Sonnberg S., Hall R. J., Peacey M., Ralston J., Webby R. J., Huang Q. S. 2010; Genotyping assay for the identification of 2009–2010 pandemic and seasonal H1N1 influenza virus reassortants. J Virol Methods 168:78–81 [CrossRef][PubMed]
    [Google Scholar]
  4. Fereidouni S. R., Starick E., Grund C., Globig A., Mettenleiter T. C., Beer M., Harder T. 2009a; Rapid molecular subtyping by reverse transcription polymerase chain reaction of the neuraminidase gene of avian influenza A viruses. Vet Microbiol 135:253–260 [CrossRef][PubMed]
    [Google Scholar]
  5. Fereidouni S. R., Beer M., Vahlenkamp T., Starick E. 2009b; Differentiation of two distinct clusters among the contemporarily circulating swine-origin influenza A (H1N1) viruses. Euro Surveil 14:19409
    [Google Scholar]
  6. Gall A., Hoffmann B., Harder T., Grund C., Beer M. 2008; Universal primer set for amplification and sequencing of HA0 cleavage sites of all influenza A viruses. J Clin Microbiol 46:2561–2567 [CrossRef][PubMed]
    [Google Scholar]
  7. Haase M., Starick E., Fereidouni S., Strebelow G., Grund C., Seeland A., Scheuner C., Cieslik D., Smietanka K., Minta Z. 2010; Possible sources and spreading routes of highly pathogenic avian influenza virus subtype H5N1 infections in poultry and wild birds in Central Europe in 2007 inferred through likelihood analyses. Infect Genet Evol 10:1075–1084 [CrossRef][PubMed]
    [Google Scholar]
  8. Hoffmann B., Harder T., Lange E., Kalthoff D., Reimann I., Grund C., Oehme R., Vahlenkamp T. W., Beer M. 2010; New real-time reverse transcriptase polymerase chain reactions facilitate detection and differentiation of novel A/H1N1 influenza virus in porcine and human samples. Berl Munch Tierarztl Wochenschr 123:286–292[PubMed]
    [Google Scholar]
  9. Howden K. J., Brockhoff E. J., Caya F. D., McLeod L. J., Lavoie M., Ing J. D., Bystrom J. M., Alexandersen S., Pasick J. M. et al. 2009; An investigation into human pandemic influenza virus (H1N1) 2009 on an Alberta swine farm. Can Vet J 50:1153–1161[PubMed]
    [Google Scholar]
  10. Kaden V., Lange E., Starick E., Bruer W., Krakowski W., Klopries M. 2008; Epidemiological survey of swine influenza A virus in selected wild boar populations in Germany. Vet Microbiol 131:123–132 [CrossRef][PubMed]
    [Google Scholar]
  11. Lange E., Kalthoff D., Blohm U., Teifke J. P., Breithaupt A., Maresch C., Starick E., Fereidouni S., Hoffmann B. et al. 2009; Pathogenesis and transmission of the novel swine-origin influenza virus A/H1N1 after experimental infection of pigs. J Gen Virol 90:2119–2123 [CrossRef][PubMed]
    [Google Scholar]
  12. Lee M. S., Chang P. C., Shien J. H., Cheng M. C., Shieh H. K. 2001; Identification and subtyping of avian influenza viruses by reverse transcription-PCR. J Virol Methods 97:13–22 [CrossRef][PubMed]
    [Google Scholar]
  13. Moreno A., Di Trani L., Alborali L., Vaccari G., Barbieri I., Falcone E., Sozzi E., Puzelli S., Ferri G., Cordioli P. 2010a; First pandemic H1N1 outbreak from a pig farm in Italy. Open Virol J 4:52–56 [CrossRef][PubMed]
    [Google Scholar]
  14. Moreno A., Di Trani L., Faccini S., Vaccari G., Nigrelli D., Boniotti M. B., Falcone E., Boni A., Chiapponi C., Sozzi E. 2010b; Novel H1N2 swine influenza reassortant strain in pigs derived from the pandemic H1N1/2009 virus. Vet Microbiol [CrossRef] (Epub ahead of print) [PubMed]
    [Google Scholar]
  15. Octaviani C. P., Ozawa M., Yamada S., Goto H., Kawaoka Y. 2010; High level of genetic compatibility between swine-origin H1N1 and highly pathogenic avian H5N1 influenza viruses. J Virol 84:10918–10922 [CrossRef][PubMed]
    [Google Scholar]
  16. Pasma T., Joseph T. 2010; Pandemic (H1N1) 2009 infection in swine herds, Manitoba, Canada. Emerg Infect Dis 16:706–708[PubMed] [CrossRef]
    [Google Scholar]
  17. Pereda A., Cappuccio J., Quiroga M. A., Baumeister E., Insarralde L., Ibar M., Sanguinetti R., Cannilla M. L., Franzese D. et al. 2010; Pandemic (H1N1) 2009 outbreak on pig farm, Argentina. Emerg Infect Dis 16:304–307[PubMed] [CrossRef]
    [Google Scholar]
  18. Smith G. J. D., Vijaykrishna D., Bahl J., Lycett S. J., Worobey M., Pybus O. G., Ma S. K., Cheung C. L., Raghwani J. et al. 2009; Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic. Nature 459:1122–1125 [CrossRef][PubMed]
    [Google Scholar]
  19. Song M. S., Lee J. H., Pascua P. N., Baek Y. H., Kwon H. I., Park K. J., Choi H. W., Shin Y. K., Song J. Y. et al. 2010; Evidence of human-to-swine transmission of the pandemic (H1N1) 2009 influenza virus in South Korea. J Clin Microbiol 48:3204–3211 [CrossRef][PubMed]
    [Google Scholar]
  20. Starick E., Fereidouni S. R., Lange E., Grund C., Vahlenkamp T., Beer M., Harder T. C. 2011; Analysis of influenza A viruses of subtype H1 from wild birds, turkeys and pigs in Germany reveals interspecies transmission events. Influenza Other Respir Viruses (in press)
    [Google Scholar]
  21. Vijaykrishna D., Poon L. L. M., Zhu H. C., Ma S. K., Li O. T. W., Cheung C. L., Smith G. J. D., Peiris J. S. M., Guan Y. 2010; Reassortment of pandemic H1N1/2009 influenza A virus in swine. Science 328:1529 [CrossRef][PubMed]
    [Google Scholar]
  22. Welsh M. D., Baird P. M., Guelbenzu-Gonzalo M. P., Hanna A., Reid S. M., Essen S., Russell C., Thomas S., Barrass L. et al. 2010; Initial incursion of pandemic (H1N1) 2009 influenza A virus into European pigs. Vet Rec 166:642–645 [CrossRef][PubMed]
    [Google Scholar]
  23. World Health Organization (2010b). H1N1 in post-pandemic period http://www.who.int/mediacentre/news/statements/2010/h1n1_vpc_20100810/en/
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