1887

Abstract

A natural reassortant influenza A virus consisting of seven genome segments from pandemic (H1N1) 2009 virus and a neuraminidase segment from a Eurasian porcine H1N1 influenza A virus was detected in a pig herd in Germany. The obvious reassortment compatibility between the pandemic (H1N1) 2009 and H1N1 viruses of porcine origin raises concern as to whether swine may become a reservoir for further reassortants of pandemic (H1N1) 2009 viruses with unknown implications for human health and swine production.

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2011-05-01
2019-10-14
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References

  1. AVMA (2010). Public health, influenza, 2009 H1N1 flu virus. American Veterinary Medical Association. http://www.avma.org/onlnews/javma/feb10/100201e.asp
  2. Brookes S. M. , Núñez A. , Choudhury B. , Matrosovich M. , Essen S. C. , Clifford D. , Slomka M. J. , Kuntz-Simon G. , Garcon F. et al. ( 2010; ). Replication, pathogenesis and transmission of pandemic (H1N1) 2009 virus in non-immune pigs. . PLoS ONE 5:, e9068. [CrossRef] [PubMed]
    [Google Scholar]
  3. Ducatez M. F. , Sonnberg S. , Hall R. J. , Peacey M. , Ralston J. , Webby R. J. , Huang Q. S. . ( 2010; ). Genotyping assay for the identification of 2009–2010 pandemic and seasonal H1N1 influenza virus reassortants. . J Virol Methods 168:, 78–81. [CrossRef] [PubMed]
    [Google Scholar]
  4. Fereidouni S. R. , Starick E. , Grund C. , Globig A. , Mettenleiter T. C. , Beer M. , Harder T. . ( 2009; a). Rapid molecular subtyping by reverse transcription polymerase chain reaction of the neuraminidase gene of avian influenza A viruses. . Vet Microbiol 135:, 253–260. [CrossRef] [PubMed]
    [Google Scholar]
  5. Fereidouni S. R. , Beer M. , Vahlenkamp T. , Starick E. . ( 2009; b). Differentiation of two distinct clusters among the contemporarily circulating swine-origin influenza A (H1N1) viruses. . Euro Surveil 14:, 19409.
    [Google Scholar]
  6. Gall A. , Hoffmann B. , Harder T. , Grund C. , Beer M. . ( 2008; ). Universal primer set for amplification and sequencing of HA0 cleavage sites of all influenza A viruses. . J Clin Microbiol 46:, 2561–2567. [CrossRef] [PubMed]
    [Google Scholar]
  7. Haase M. , Starick E. , Fereidouni S. , Strebelow G. , Grund C. , Seeland A. , Scheuner C. , Cieslik D. , Smietanka K. , Minta Z. . ( 2010; ). Possible sources and spreading routes of highly pathogenic avian influenza virus subtype H5N1 infections in poultry and wild birds in Central Europe in 2007 inferred through likelihood analyses. . Infect Genet Evol 10:, 1075–1084. [CrossRef] [PubMed]
    [Google Scholar]
  8. Hoffmann B. , Harder T. , Lange E. , Kalthoff D. , Reimann I. , Grund C. , Oehme R. , Vahlenkamp T. W. , Beer M. . ( 2010; ). New real-time reverse transcriptase polymerase chain reactions facilitate detection and differentiation of novel A/H1N1 influenza virus in porcine and human samples. . Berl Munch Tierarztl Wochenschr 123:, 286–292.[PubMed]
    [Google Scholar]
  9. Howden K. J. , Brockhoff E. J. , Caya F. D. , McLeod L. J. , Lavoie M. , Ing J. D. , Bystrom J. M. , Alexandersen S. , Pasick J. M. et al. ( 2009; ). An investigation into human pandemic influenza virus (H1N1) 2009 on an Alberta swine farm. . Can Vet J 50:, 1153–1161.[PubMed]
    [Google Scholar]
  10. Kaden V. , Lange E. , Starick E. , Bruer W. , Krakowski W. , Klopries M. . ( 2008; ). Epidemiological survey of swine influenza A virus in selected wild boar populations in Germany. . Vet Microbiol 131:, 123–132. [CrossRef] [PubMed]
    [Google Scholar]
  11. Lange E. , Kalthoff D. , Blohm U. , Teifke J. P. , Breithaupt A. , Maresch C. , Starick E. , Fereidouni S. , Hoffmann B. et al. ( 2009; ). Pathogenesis and transmission of the novel swine-origin influenza virus A/H1N1 after experimental infection of pigs. . J Gen Virol 90:, 2119–2123. [CrossRef] [PubMed]
    [Google Scholar]
  12. Lee M. S. , Chang P. C. , Shien J. H. , Cheng M. C. , Shieh H. K. . ( 2001; ). Identification and subtyping of avian influenza viruses by reverse transcription-PCR. . J Virol Methods 97:, 13–22. [CrossRef] [PubMed]
    [Google Scholar]
  13. Moreno A. , Di Trani L. , Alborali L. , Vaccari G. , Barbieri I. , Falcone E. , Sozzi E. , Puzelli S. , Ferri G. , Cordioli P. . ( 2010; a). First pandemic H1N1 outbreak from a pig farm in Italy. . Open Virol J 4:, 52–56. [CrossRef] [PubMed]
    [Google Scholar]
  14. Moreno A. , Di Trani L. , Faccini S. , Vaccari G. , Nigrelli D. , Boniotti M. B. , Falcone E. , Boni A. , Chiapponi C. , Sozzi E. . ( 2010; b). Novel H1N2 swine influenza reassortant strain in pigs derived from the pandemic H1N1/2009 virus. . Vet Microbiol [CrossRef] (Epub ahead of print).[PubMed]
    [Google Scholar]
  15. Octaviani C. P. , Ozawa M. , Yamada S. , Goto H. , Kawaoka Y. . ( 2010; ). High level of genetic compatibility between swine-origin H1N1 and highly pathogenic avian H5N1 influenza viruses. . J Virol 84:, 10918–10922. [CrossRef] [PubMed]
    [Google Scholar]
  16. Pasma T. , Joseph T. . ( 2010; ). Pandemic (H1N1) 2009 infection in swine herds, Manitoba, Canada. . Emerg Infect Dis 16:, 706–708.[PubMed] [CrossRef]
    [Google Scholar]
  17. Pereda A. , Cappuccio J. , Quiroga M. A. , Baumeister E. , Insarralde L. , Ibar M. , Sanguinetti R. , Cannilla M. L. , Franzese D. et al. ( 2010; ). Pandemic (H1N1) 2009 outbreak on pig farm, Argentina. . Emerg Infect Dis 16:, 304–307.[PubMed] [CrossRef]
    [Google Scholar]
  18. Smith G. J. D. , Vijaykrishna D. , Bahl J. , Lycett S. J. , Worobey M. , Pybus O. G. , Ma S. K. , Cheung C. L. , Raghwani J. et al. ( 2009; ). Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic. . Nature 459:, 1122–1125. [CrossRef] [PubMed]
    [Google Scholar]
  19. Song M. S. , Lee J. H. , Pascua P. N. , Baek Y. H. , Kwon H. I. , Park K. J. , Choi H. W. , Shin Y. K. , Song J. Y. et al. ( 2010; ). Evidence of human-to-swine transmission of the pandemic (H1N1) 2009 influenza virus in South Korea. . J Clin Microbiol 48:, 3204–3211. [CrossRef] [PubMed]
    [Google Scholar]
  20. Starick E. , Fereidouni S. R. , Lange E. , Grund C. , Vahlenkamp T. , Beer M. , Harder T. C. . ( 2011; ). Analysis of influenza A viruses of subtype H1 from wild birds, turkeys and pigs in Germany reveals interspecies transmission events. . Influenza Other Respir Viruses (in press). [CrossRef]
    [Google Scholar]
  21. Vijaykrishna D. , Poon L. L. M. , Zhu H. C. , Ma S. K. , Li O. T. W. , Cheung C. L. , Smith G. J. D. , Peiris J. S. M. , Guan Y. . ( 2010; ). Reassortment of pandemic H1N1/2009 influenza A virus in swine. . Science 328:, 1529. [CrossRef] [PubMed]
    [Google Scholar]
  22. Welsh M. D. , Baird P. M. , Guelbenzu-Gonzalo M. P. , Hanna A. , Reid S. M. , Essen S. , Russell C. , Thomas S. , Barrass L. et al. ( 2010; ). Initial incursion of pandemic (H1N1) 2009 influenza A virus into European pigs. . Vet Rec 166:, 642–645. [CrossRef] [PubMed]
    [Google Scholar]
  23. World Health Organization (2010a). Influenza update. http://www.who.int/csr/disease/influenza/2010_12_30_GIP_surveillance/en/index.html
  24. World Health Organization (2010b). H1N1 in post-pandemic period. http://www.who.int/mediacentre/news/statements/2010/h1n1_vpc_20100810/en/
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vol. , part 5, pp. 1184 - 1188

Antigenic characterization by haemagglutination inhibition assay of swine influenza viruses isolates molecularly characterized in this study [PDF](15 KB)



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