1887

Abstract

The recent discovery of hepatitis C virus (HCV)-related viruses in different animal species has raised new speculations regarding the origin of HCV and the possibility of a zoonotic source responsible for the endemic HCV transmission. As a consequence, these new findings prompt questions regarding the potential for cross-species transmissions of hepaciviruses. The closest relatives to HCV discovered to date are the non-primate hepaciviruses (NPHVs), which have been described to infect horses. To evaluate the risk of a potential zoonotic transmission, we analysed NPHV RNA and antibodies in humans with occupational exposure to horses in comparison with a low-risk group. Both groups were negative for NPHV RNA, even though low seroreactivities against various NPHV antigens could be detected irrespective of the group. In conclusion, we did not observe evidence of NPHV transmission between horses and humans.

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2015-09-01
2021-10-16
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References

  1. Alter M.J. 2007; Epidemiology of hepatitis C virus infection. World J Gastroenterol 13:2436–2441 [View Article][PubMed]
    [Google Scholar]
  2. Burbelo P.D., Dubovi E.J., Simmonds P., Medina J.L., Henriquez J.A., Mishra N., Wagner J., Tokarz R., Cullen J.M., other authors. 2012; Serology-enabled discovery of genetically diverse hepaciviruses in a new host. J Virol 86:6171–6178 [View Article][PubMed]
    [Google Scholar]
  3. Chandriani S., Skewes-Cox P., Zhong W., Ganem D.E., Divers T.J., Van Blaricum A.J., Tennant B.C., Kistler A.L. 2013; Identification of a previously undescribed divergent virus from the Flaviviridae family in an outbreak of equine serum hepatitis. Proc Natl Acad Sci U S A 110:E1407–E1415 [View Article][PubMed]
    [Google Scholar]
  4. Drexler J.F., Corman V.M., Müller M.A., Lukashev A.N., Gmyl A., Coutard B., Adam A., Ritz D., Leijten L.M., other authors. 2013; Evidence for novel hepaciviruses in rodents. PLoS Pathog 9:e1003438 [View Article][PubMed]
    [Google Scholar]
  5. Firth C., Bhat M., Firth M.A., Williams S.H., Frye M.J., Simmonds P., Conte J.M., Ng J., Garcia J., other authors. 2014; Detection of zoonotic pathogens and characterization of novel viruses carried by commensal Rattus norvegicus in New York City. MBio 5:e01933–14 [View Article][PubMed]
    [Google Scholar]
  6. Heim M.H., Thimme R. 2014; Innate and adaptive immune responses in HCV infections. J Hepatol 61:S14–S25 [View Article][PubMed]
    [Google Scholar]
  7. Kapoor A., Simmonds P., Gerold G., Qaisar N., Jain K., Henriquez J.A., Firth C., Hirschberg D.L., Rice C.M., other authors. 2011; Characterization of a canine homolog of hepatitis C virus. Proc Natl Acad Sci U S A 108:11608–11613 [View Article][PubMed]
    [Google Scholar]
  8. Kapoor A., Simmonds P., Scheel T.K., Hjelle B., Cullen J.M., Burbelo P.D., Chauhan L.V., Duraisamy R., Sanchez Leon M., other authors. 2013; Identification of rodent homologs of hepatitis C virus and pegiviruses. MBio 4:e00216-13 [View Article][PubMed]
    [Google Scholar]
  9. Lauck M., Sibley S.D., Lara J., Purdy M.A., Khudyakov Y., Hyeroba D., Tumukunde A., Weny G., Switzer W.M., other authors. 2013; A novel hepacivirus with an unusually long and intrinsically disordered NS5A protein in a wild Old World primate. J Virol 87:8971–8981 [View Article][PubMed]
    [Google Scholar]
  10. Levi J.E., Cabral S.P., Nishiya A., Ferreira S., Romano C.M., Polite M.B., Pereira R.A., Mota M.A., Kutner J.M. 2014; Absence of nonprimate hepacivirus-related genomes in blood donors seroreactive for hepatitis C virus displaying indeterminate blot patterns. J Viral Hepat 21:e164–e166 [View Article][PubMed]
    [Google Scholar]
  11. Li X.D., Sun L., Seth R.B., Pineda G., Chen Z.J. 2005; Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity. Proc Natl Acad Sci U S A 102:17717–17722 [View Article][PubMed]
    [Google Scholar]
  12. Lyons S., Kapoor A., Schneider B.S., Wolfe N.D., Culshaw G., Corcoran B., Durham A.E., Burden F., McGorum B.C., Simmonds P. 2014; Viraemic frequencies and seroprevalence of non-primate hepacivirus and equine pegiviruses in horses and other mammalian species. J Gen Virol 95:1701–1711 [View Article][PubMed]
    [Google Scholar]
  13. O'Shea T.J., Cryan P.M., Cunningham A.A., Fooks A.R., Hayman D.T., Luis A.D., Peel A.J., Plowright R.K., Wood J.L. 2014; Bat flight and zoonotic viruses. Emerg Infect Dis 20:741–745 [View Article][PubMed]
    [Google Scholar]
  14. Parera M., Martrus G., Franco S., Clotet B., Martinez M.A. 2012; Canine hepacivirus NS3 serine protease can cleave the human adaptor proteins MAVS and TRIF. PLoS One 7:e42481 [View Article][PubMed]
    [Google Scholar]
  15. Pawlotsky J.M. 2013; Treatment of chronic hepatitis C: current and future. Curr Top Microbiol Immunol 369:321–342[PubMed]
    [Google Scholar]
  16. Pfaender S., Brown R.J.P., Pietschmann T., Steinmann E. 2014; Natural reservoirs for homologs of hepatitis C virus. Emerg Microbes Infect 3:e21 [CrossRef]
    [Google Scholar]
  17. Pfaender S., Cavalleri J.M., Walter S., Doerrbecker J., Campana B., Brown R.J., Burbelo P.D., Postel A., Hahn K., other authors. 2015; Clinical course of infection and viral tissue tropism of hepatitis C virus-like non-primate hepaciviruses in horses. Hepatology 61:447–459[PubMed] [CrossRef]
    [Google Scholar]
  18. Quan P.L., Firth C., Conte J.M., Williams S.H., Zambrana-Torrelio C.M., Anthony S.J., Ellison J.A., Gilbert A.T., Kuzmin I.V., other authors. 2013; Bats are a major natural reservoir for hepaciviruses and pegiviruses. Proc Natl Acad Sci U S A 110:8194–8199 [View Article][PubMed]
    [Google Scholar]
  19. Ramsay J.D., Evanoff R., Wilkinson T.E. Jr, Divers T.J., Knowles D.P., Mealey R.H. 2015; Experimental transmission of equine hepacivirus in horses as a model for hepatitis C virus. Hepatology 61:1533–1546 [View Article][PubMed]
    [Google Scholar]
  20. Scheel T.K., Simmonds P., Kapoor A. 2015; Surveying the global virome: identification and characterization of HCV-related animal hepaciviruses. Antiviral Res 115:83–93[PubMed] [CrossRef]
    [Google Scholar]
  21. Sharp P.M., Rayner J.C., Hahn B.H. 2013; Evolution. Great apes and zoonoses. Science 340:284–286 [View Article][PubMed]
    [Google Scholar]
  22. Simmonds P., Bukh J., Combet C., Deléage G., Enomoto N., Feinstone S., Halfon P., Inchauspé G., Kuiken C., other authors. 2005; Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes. Hepatology 42:962–973 [View Article][PubMed]
    [Google Scholar]
  23. Steinmann E., Pietschmann T. 2013; Cell culture systems for hepatitis C virus. Curr Top Microbiol Immunol 369:17–48[PubMed]
    [Google Scholar]
  24. Tamura K., Stecher G., Peterson D., Filipski A., Kumar S. 2013; MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Mol Biol Evol 30:2725–2729 [View Article][PubMed]
    [Google Scholar]
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