RT Journal Article SR Electronic(1) A1 Pfaender, Stephanie A1 Walter, Stephanie A1 Todt, Daniel A1 Behrendt, Patrick A1 Doerrbecker, Juliane A1 Wölk, Benno A1 Engelmann, Michael A1 Gravemann, Ute A1 Seltsam, Axel A1 Steinmann, Joerg A1 Burbelo, Peter D. A1 Klawonn, Frank A1 Feige, Karsten A1 Pietschmann, Thomas A1 Cavalleri, Jessika-M. V. A1 Steinmann, EikeYR 2015 T1 Assessment of cross-species transmission of hepatitis C virus-related non-primate hepacivirus in a population of humans at high risk of exposure JF Journal of General Virology, VO 96 IS 9 SP 2636 OP 2642 DO https://doi.org/10.1099/vir.0.000208 PB Microbiology Society, SN 1465-2099, AB The recent discovery of hepatitis C virus (HCV)-related viruses in different animal species has raised new speculations regarding the origin of HCV and the possibility of a zoonotic source responsible for the endemic HCV transmission. As a consequence, these new findings prompt questions regarding the potential for cross-species transmissions of hepaciviruses. The closest relatives to HCV discovered to date are the non-primate hepaciviruses (NPHVs), which have been described to infect horses. To evaluate the risk of a potential zoonotic transmission, we analysed NPHV RNA and antibodies in humans with occupational exposure to horses in comparison with a low-risk group. Both groups were negative for NPHV RNA, even though low seroreactivities against various NPHV antigens could be detected irrespective of the group. In conclusion, we did not observe evidence of NPHV transmission between horses and humans., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.000208