1887

Abstract

Hepatitis E virus (HEV) infection causes high mortality in pregnant women. However, the pathogenic mechanisms of HEV infection in pregnant women remain unknown. In this study, the roles of pregnancy serum in HEV infection were investigated using an efficient cell culture system. HEV infection was exacerbated by supplementing with pregnancy serum, especially theat in third trimester of pregnancy. Oestrogen receptors (ER-α and ER-β) were activated in cells supplemented with pregnancy serum and were significantly inhibited during HEV infection. Type I IFN, especially IFN-β, showed delayed upregulation in HEV-infected cells supplemented with the serum in the third trimester of pregnancy, which indicated that delayed IFN-β expression may facilitate viral replication. Results suggested that pregnancy serum accelerated HEV replication by suppressing oestrogen receptors and type I IFN in the early stage of infection.

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2015-05-01
2021-07-25
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References

  1. Aggarwal R., Jameel S. 2011; Hepatitis E. Hepatology 54:2218–2226 [View Article][PubMed]
    [Google Scholar]
  2. Aggarwal R., Krawczynski K. 2000; Hepatitis E: an overview and recent advances in clinical and laboratory research. J Gastroenterol Hepatol 15:9–20 [View Article][PubMed]
    [Google Scholar]
  3. Arankalle V. A., Chadha M. S., Dama B. M., Tsarev S. A., Purcell R. H., Banerjee K. 1998; Role of immune serum globulins in pregnant women during an epidemic of hepatitis E. J Viral Hepat 5:199–204 [View Article][PubMed]
    [Google Scholar]
  4. Baden R., Rockstroh J. K., Buti M. 2014; Natural history and management of hepatitis C: does sex play a role?. J Infect Dis 209: Suppl 3 S81–S85 [View Article][PubMed]
    [Google Scholar]
  5. Biswas D. K., Singh S., Shi Q., Pardee A. B., Iglehart J. D. 2005; Crossroads of estrogen receptor and NF-kappaB signaling. Sci STKE 2005:pe27[PubMed]
    [Google Scholar]
  6. Calippe B., Douin-Echinard V., Delpy L., Laffargue M., Lélu K., Krust A., Pipy B., Bayard F., Arnal J. F. et al. 2010; 17Beta-estradiol promotes TLR4-triggered proinflammatory mediator production through direct estrogen receptor alpha signaling in macrophages in vivo . J Immunol 185:1169–1176 [View Article][PubMed]
    [Google Scholar]
  7. Devhare P. B., Chatterjee S. N., Arankalle V. A., Lole K. S. 2013; Analysis of antiviral response in human epithelial cells infected with hepatitis E virus. PLoS ONE 8:e63793 [View Article][PubMed]
    [Google Scholar]
  8. Dong C., Zafrullah M., Mixson-Hayden T., Dai X., Liang J., Meng J., Kamili S. 2012; Suppression of interferon-α signaling by hepatitis E virus. Hepatology 55:1324–1332 [View Article][PubMed]
    [Google Scholar]
  9. Forbes R. L., Gibson P. G., Murphy V. E., Wark P. A. 2012; Impaired type I and III interferon response to rhinovirus infection during pregnancy and asthma. Thorax 67:209–214 [View Article][PubMed]
    [Google Scholar]
  10. Hochhaus A., Burchert A. 2010; Reply to V. Pitini et al . J Clin Oncol 28:e440 [View Article]
    [Google Scholar]
  11. Huang F. F., Haqshenas G., Guenette D. K., Halbur P. G., Schommer S. K., Pierson F. W., Toth T. E., Meng X. J. 2002; Detection by reverse transcription-PCR and genetic characterization of field isolates of swine hepatitis E virus from pigs in different geographic regions of the United States. J Clin Microbiol 40:1326–1332 [View Article][PubMed]
    [Google Scholar]
  12. Huang F., Yu W., Hua X., Jing S., Zeng W., He Z. 2011; Seroepidemiology and molecular characterization of hepatitis E Virus in Macaca mulatta from a village in Yunnan, China, where infection with this virus is endemic. Hepat Mon 11:745–749 [View Article][PubMed]
    [Google Scholar]
  13. Huang F., Ma T., Li L., Zeng W., Jing S. 2013; Low seroprevalence of hepatitis E virus infection in pregnant women in Yunnan, China. Braz J Infect Dis 17:716–717 [View Article][PubMed]
    [Google Scholar]
  14. Huang R., Li D., Wei S., Li Q., Yuan X., Geng L., Li X., Liu M. 1999; Cell culture of sporadic hepatitis E virus in China. Clin Diagn Lab Immunol 6:729–733[PubMed]
    [Google Scholar]
  15. Jilani N., Das B. C., Husain S. A., Baweja U. K., Chattopadhya D., Gupta R. K., Sardana S., Kar P. 2007; Hepatitis E virus infection and fulminant hepatic failure during pregnancy. J Gastroenterol Hepatol 22:676–682 [View Article][PubMed]
    [Google Scholar]
  16. Kamar N., Selves J., Mansuy J. M., Ouezzani L., Péron J. M., Guitard J., Cointault O., Esposito L., Abravanel F. et al. 2008; Hepatitis E virus and chronic hepatitis in organ-transplant recipients. N Engl J Med 358:811–817 [View Article][PubMed]
    [Google Scholar]
  17. Kourtis A. P., Read J. S., Jamieson D. J. 2014; Pregnancy and infection. N Engl J Med 370:2211–2218 [View Article][PubMed]
    [Google Scholar]
  18. Labrique A. B., Sikder S. S., Krain L. J., West K. P. Jr, Christian P., Rashid M., Nelson K. E. 2012; Hepatitis E, a vaccine-preventable cause of maternal deaths. Emerg Infect Dis 18:1401–1404 [View Article][PubMed]
    [Google Scholar]
  19. Łapiński T. W., Szulzyk T., Flisiak R. 2010; [HBV infection and pregnancy]. Przegl Epidemiol 64:503–507 (in Polish) [PubMed]
    [Google Scholar]
  20. Navaneethan U., Al Mohajer M., Shata M. T. 2008; Hepatitis E and pregnancy: understanding the pathogenesis. Liver Int 28:1190–1199 [View Article][PubMed]
    [Google Scholar]
  21. Okamoto H. 2010; [Cell culture system for hepatitis E virus]. Uirusu 60:93–104 (in Japanese) [View Article][PubMed]
    [Google Scholar]
  22. Pazos M. A., Kraus T. A., Muñoz-Fontela C., Moran T. M. 2012; Estrogen mediates innate and adaptive immune alterations to influenza infection in pregnant mice. PLoS ONE 7:e40502 [View Article][PubMed]
    [Google Scholar]
  23. Rein D. B., Stevens G. A., Theaker J., Wittenborn J. S., Wiersma S. T. 2012; The global burden of hepatitis E virus genotypes 1 and 2 in 2005. Hepatology 55:988–997 [View Article][PubMed]
    [Google Scholar]
  24. Seczyńska B., Jankowski M., Nowak I., Szczeklik W., Szułdrzyński K., Królikowski W. 2014; Pregnancy-related H1N1 influenza and severe acute respiratory distress syndrome successfully treated with extracorporeal membrane oxygenation despite difficult vascular access. Pol Arch Med Wewn 124:136–137[PubMed]
    [Google Scholar]
  25. Shimizu I. 2003; Impact of oestrogens on the progression of liver disease. Liver Int 23:63–69 [View Article][PubMed]
    [Google Scholar]
  26. Takahashi H., Tanaka T., Jirintai S., Nagashima S., Takahashi M., Nishizawa T., Mizuo H., Yazaki Y., Okamoto H. 2012; A549 and PLC/PRF/5 cells can support the efficient propagation of swine and wild boar hepatitis E virus (HEV) strains: demonstration of HEV infectivity of porcine liver sold as food. Arch Virol 157:235–246 [View Article][PubMed]
    [Google Scholar]
  27. Tanaka T., Takahashi M., Kusano E., Okamoto H. 2007; Development and evaluation of an efficient cell-culture system for Hepatitis E virus. J Gen Virol 88:903–911 [View Article][PubMed]
    [Google Scholar]
  28. Than N. N., Neuberger J. 2013; Liver abnormalities in pregnancy. Best Pract Res Clin Gastroenterol 27:565–575 [View Article][PubMed]
    [Google Scholar]
  29. Versluis J., Pas S. D., Agteresch H. J., de Man R. A., Maaskant J., Schipper M. E., Osterhaus A. D., Cornelissen J. J., van der Eijk A. A. 2013; Hepatitis E virus: an underestimated opportunistic pathogen in recipients of allogeneic hematopoietic stem cell transplantation. Blood 122:1079–1086 [View Article][PubMed]
    [Google Scholar]
  30. Wang S. H., Yeh S. H., Lin W. H., Yeh K. H., Yuan Q., Xia N. S., Chen D. S., Chen P. J. 2012; Estrogen receptor α represses transcription of HBV genes via interaction with hepatocyte nuclear factor 4α. Gastroenterology 142:989–998 [View Article][PubMed]
    [Google Scholar]
  31. Weber F., Kochs G., Haller O. 2004; Inverse interference: how viruses fight the interferon system. Viral Immunol 17:498–515 [View Article][PubMed]
    [Google Scholar]
  32. Wong S. F., Chow K. M., de Swiet M. 2003; Severe acute respiratory syndrome and pregnancy. BJOG 110:641–642 [View Article][PubMed]
    [Google Scholar]
  33. Yan Z., Tan W., Xu B., Dan Y., Zhao W., Deng C., Chen W., Tan S., Mao Q. et al. 2011; A cis-acting regulatory variation of the estrogen receptor α (ESR1) gene is associated with hepatitis B virus-related liver cirrhosis. Hum Mutat 32:1128–1136 [View Article][PubMed]
    [Google Scholar]
  34. Yu C., Boon D., McDonald S. L., Myers T. G., Tomioka K., Nguyen H., Engle R. E., Govindarajan S., Emerson S. U., Purcell R. H. 2010; Pathogenesis of hepatitis E virus and hepatitis C virus in chimpanzees: similarities and differences. J Virol 84:11264–11278 [View Article][PubMed]
    [Google Scholar]
  35. Zhou X., Wang Y., Metselaar H. J., Janssen H. L., Peppelenbosch M. P., Pan Q. 2014; Rapamycin and everolimus facilitate hepatitis E virus replication: revealing a basal defense mechanism of PI3K-PKB-mTOR pathway. J Hepatol 61:746–754 [View Article][PubMed]
    [Google Scholar]
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