1887

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Volume 104, Issue 4

Mechanisms of bunyavirus morphogenesis and egress Open Access

Abstract

Unlike many segmented negative-sense RNA viruses, most members of the bud at Golgi membranes, as opposed to the plasma membrane. Central players in this assembly process are the envelope glycoproteins, Gn and Gc, which upon translation undergo proteolytic processing, glycosylation and trafficking to the Golgi, where they interact with ribonucleoprotein genome segments and bud into Golgi-derived compartments. The processes involved in genome packaging during virion assembly can lead to the generation of reassorted viruses, if a cell is co-infected with two different bunyaviruses, due to mismatching of viral genome segment packaging. This can lead to viruses with high pathogenic potential, as demonstrated by the emergence of Schmallenberg virus. This review focuses on the assembly pathways of tri-segmented bunyaviruses, highlighting some areas in need of further research to understand these important pathogens with zoonotic potential.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): bunyavirus , genome packaging , glycoprotein , reassortment and virus assembly
Funding
This study was supported by the:
  • Wellcome Trust
    • Principle Award Recipient: JakeBarker
  • Academy of Medical Sciences (Award NAF\R10\100033)
    • Principle Award Recipient: LuisL. P. da Silva
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (Award 19/02418-9)
    • Principle Award Recipient: LuisL. P. da Silva
  • Biotechnology and Biological Sciences Research Council (Award BB/S018670/1)
    • Principle Award Recipient: ColinM. Crump
© 2023 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2023-04-21
2024-05-14
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Mechanisms of bunyavirus morphogenesis and egress
J. Gen. Virol. 104, 001845 (2023); https://doi.org/10.1099/jgv.0.001845
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