1887

Abstract

The γ-herpesviruses have proved hard to vaccination against, with no convincing protection against long-term latent infection by recombinant viral subunits. In experimental settings, whole-virus vaccines have proved more effective, even when the vaccine virus itself establishes latent infection poorly. The main alternative is replication-deficient virus particles. Here high-dose, replication-deficient murid herpesvirus-4 only protected mice partially against wild-type infection. By contrast, latency-deficient but replication-competent vaccine protected mice strongly, even when delivered non-invasively to the olfactory epithelium. Thus, this approach seems to provide the best chance of a safe and effective γ-herpesvirus vaccine.

Funding
This study was supported by the:
  • Australian Research Council (Award DP190101851)
    • Principle Award Recipient: Philip G. Stevenson
  • National Health and Medical Research Council (Award 1140169)
    • Principle Award Recipient: Philip G. Stevenson
  • National Health and Medical Research Council (Award 1122070)
    • Principle Award Recipient: Philip G. Stevenson
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2020-01-27
2024-05-14
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