1887

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Volume 98, Issue 5

Recombination events and variability among full-length genomes of co-circulating molluscum contagiosum virus subtypes 1 and 2 Free

Abstract

(MCV) is the sole member of the genus and causes a highly prevalent human disease of the skin characterized by the formation of a variable number of lesions that can persist for prolonged periods of time. Two major genotypes, subtype 1 and subtype 2, are recognized, although currently only a single complete genomic sequence corresponding to MCV subtype 1 is available. Using next-generation sequencing techniques, we report the complete genomic sequence of four new MCV isolates, including the first one derived from a subtype 2. Comparisons suggest a relatively distant evolutionary split between both MCV subtypes. Further, our data illustrate concurrent circulation of distinct viruses within a population and reveal the existence of recombination events among them. These results help identify a set of MCV genes with potentially relevant roles in molluscum contagiosum epidemiology and pathogenesis.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): Molluscum contagiosum virus , poxvirus , skin disease and strain variability
© 2017 The Authors
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2017-05-01
2023-09-22
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Recombination events and variability among full-length genomes of co-circulating molluscum contagiosum virus subtypes 1 and 2
J. Gen. Virol. 98, 1073 (2017); https://doi.org/10.1099/jgv.0.000759
/content/journal/jgv/10.1099/jgv.0.000759
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