RT Journal Article SR Electronic(1) A1 López-Bueno, Alberto A1 Parras-Moltó, Marcos A1 López-Barrantes, Olivia A1 Belda, Sylvia A1 Alejo, AlíYR 2017 T1 Recombination events and variability among full-length genomes of co-circulating molluscum contagiosum virus subtypes 1 and 2 JF Journal of General Virology, VO 98 IS 5 SP 1073 OP 1079 DO https://doi.org/10.1099/jgv.0.000759 PB Microbiology Society, SN 1465-2099, AB Molluscum contagiosum virus (MCV) is the sole member of the Molluscipoxvirus genus and causes a highly prevalent human disease of the skin characterized by the formation of a variable number of lesions that can persist for prolonged periods of time. Two major genotypes, subtype 1 and subtype 2, are recognized, although currently only a single complete genomic sequence corresponding to MCV subtype 1 is available. Using next-generation sequencing techniques, we report the complete genomic sequence of four new MCV isolates, including the first one derived from a subtype 2. Comparisons suggest a relatively distant evolutionary split between both MCV subtypes. Further, our data illustrate concurrent circulation of distinct viruses within a population and reveal the existence of recombination events among them. These results help identify a set of MCV genes with potentially relevant roles in molluscum contagiosum epidemiology and pathogenesis., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.000759