1887

Abstract

A mouse model was developed to study the virus- host interaction of molecularly cloned human foamy virus (HFV) . The infectious process was analysed in two mouse strains, CBA/Ca and C57BL/ 6J, over a period of 24 weeks by PCR on DNAs from various animal tissues; virus serology was examined by immunoblotting. The infection persisted in both mouse strains and did not induce clinical symptoms. Upon infection of adult CBA/Ca mice HFV became detectable by PCR in an increasing number of organs over time. In contrast, in C57BL/6J mice, after an initial phase of dissemination, viral DNA sequences were found only in a few organs. Interestingly, the different course of infection was accompanied by differences in the antiviral immune response. In particular, C57BL/6J mice were high responders with respect to antibodies to the viral Bet protein, while CBA/Ca mice were low responders.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-78-8-1929
1997-08-01
2022-05-23
Loading full text...

Full text loading...

/deliver/fulltext/jgv/78/8/9266990.html?itemId=/content/journal/jgv/10.1099/0022-1317-78-8-1929&mimeType=html&fmt=ahah

References

  1. Aguzzi A., Marino S., Tschopp R., Rethwilm A. 1996; Regulation of expression and pathogenic potential of human foamy virus in vitro and in transgenic mice. Current Topics in Microbiology and Immunology 206:243–273
    [Google Scholar]
  2. Baunach G., Maurer B., Hahn H., Kranz M., Rethwilm A. 1993; Functional analysis of human foamy virus accessory reading frames. Journal of Virology 67:5411–5418
    [Google Scholar]
  3. Brown P., Moreau-Dubois M. C., Gajdusek D. C. 1982; Persistent asymptomatic infection of the laboratory mouse by simian foamy virus type 6: a new model of retrovirus latency. Archives of Virology 71:229–234
    [Google Scholar]
  4. Fischer N., Enssle J., Muller J., Rethwilm A., Niewiesk S. 1997; Characterization of human foamy virus proteins expressed by recombinant vaccinia viruses. AIDS Research and Human Retroviruses in press
    [Google Scholar]
  5. Hahn H., Baunach G., Bräutigam S., Mergia A., Neumann-Haefelin D., Daniel M. D., McClure M. O., Rethwilm A. 1994; Reactivity of primate sera to foamy virus gag and bet proteins. Journal of General Virology 75:2635–2644
    [Google Scholar]
  6. Hooks J. J., Detrick-Hooks B. 1979; Simian foamy virus-induced immunosuppression in rabbits. Journal of General Virology 44:383–390
    [Google Scholar]
  7. Johnston P. 1974; Studies on simian foamy viruses and syncytiumforming viruses of lower animals. Laboratory Animal Science 24:159–166
    [Google Scholar]
  8. Netzer K. -O., Rethwilm A., Maurer B., ter Meulen V. 1990; Identification of the major immunogenic structural proteins of human foamy virus. Journal of General Virology 71:1237–1241
    [Google Scholar]
  9. Rethwilm A. 1995; Regulation offoamy virus gene expression. Current Topics in Microbiology and Immunology 193:1–24
    [Google Scholar]
  10. Rethwilm A. 1996; Unexpected replication pathways of foamy virus. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 13:S248–S253
    [Google Scholar]
  11. Rösener M., Hahn H., Kranz M., Heeney J., Rethwilm A. 1996; Absence of serological evidence for foamy virus infection in patients with amyotrophic lateral sclerosis. Journal of Medical Virology 48:222–226
    [Google Scholar]
  12. Saib A., Neves M., Giron M. -L., Guillemin M. -C., Valla J., Peries J., Canivet M. 1997; Long-term persistent infection of domestic rabbits by the human foamy virus. Virology 228:263–268
    [Google Scholar]
  13. Santillana-Hayat M., Rozain F., Bittoun P., Chopin-Robert C., Lasueret J., Peries J., Canivet M. 1993; Transient immunosuppressive effect induced in rabbits and mice by the human spuma- retrovirus prototype human foamy virus (HFV). Research in Virology 144:389–396
    [Google Scholar]
  14. Schmidt M., Rethwilm A. 1995; Replicating foamy virus-based vectors directing high level expression of foreign genes. Virology 210:167–178
    [Google Scholar]
  15. Schmidt M., Herchenröder O., Heeney J. L., Rethwilm A. 1997; Long terminal repeat U3 length polymorphism of human foamy virus. Virology 230:167–178
    [Google Scholar]
  16. Schweizer M., Turek R., Reinhardt M., Neumann-Haefelin D. 1994; Absence of foamy virus DNA in Graves' disease. AIDS Research and Human Retroviruses 10:601–605
    [Google Scholar]
  17. Schweizer M., Turek R., Hahn H., Schliephake A., Netzer K. -O., Eder G., Reinhardt M., Rethwilm A., Neumann-Haefelin D. 1995; Markers of foamy virus infections in monkeys, apes, and accidentally infected humans: appropriate testing fails to confirm suspected foamy virus prevalence in humans. AIDS Research and Human Retroviruses 11:161–169
    [Google Scholar]
  18. Schwender S., Imrich H., Dörries R. 1991; The pathogenic role of virus-specific antibody-secreting cells in the central nervous system of rats with different susceptibility to coronavirus-induced demyelinating encephalitis. Immunology 74:533–538
    [Google Scholar]
  19. Swack N. S., Hsiung G. D. 1975; Pathog enesis of simian foamy virus infection in natural and experimental hosts. Infection and Immunity 12:470–474
    [Google Scholar]
  20. von Laer D., Neumann-Haefelin D., Heeney J. L., Schweizer M. 1996; Lymphocytes are the major reservoir for foamy viruses in peripheral blood. Virology 221:240–244
    [Google Scholar]
  21. Yu S., Linial M. L. 1993; Analysis of the role of the bel and bet open reading frames of human foamy virus by using a new quantitative assay. Journal of Virology 67:6618–6624
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-78-8-1929
Loading
/content/journal/jgv/10.1099/0022-1317-78-8-1929
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error