@article{mbs:/content/journal/jgv/10.1099/0022-1317-78-8-1929, author = "Schmidt, Martina and Niewiesk, Stefan and Heeney, Jonathon and Aguzzi, Adriano and Rethwilm, Axel", title = "Mouse model to study the replication of primate foamy viruses", journal= "Journal of General Virology", year = "1997", volume = "78", number = "8", pages = "1929-1933", doi = "https://doi.org/10.1099/0022-1317-78-8-1929", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-78-8-1929", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "A mouse model was developed to study the virus- host interaction of molecularly cloned human foamy virus (HFV) in vivo. The infectious process was analysed in two mouse strains, CBA/Ca and C57BL/ 6J, over a period of 24 weeks by PCR on DNAs from various animal tissues; virus serology was examined by immunoblotting. The infection persisted in both mouse strains and did not induce clinical symptoms. Upon infection of adult CBA/Ca mice HFV became detectable by PCR in an increasing number of organs over time. In contrast, in C57BL/6J mice, after an initial phase of dissemination, viral DNA sequences were found only in a few organs. Interestingly, the different course of infection was accompanied by differences in the antiviral immune response. In particular, C57BL/6J mice were high responders with respect to antibodies to the viral Bet protein, while CBA/Ca mice were low responders.", }