1887

Abstract

The complete nucleotide sequence of the provirus of feline foamy virus (FeFV), strain F-17, was determined, and compared to the available data for human and simian spumaviruses. In addition to the usual retroviral and genes, two open reading frames are present between the gene and the 3′-LTR, as in the simian spumaviruses, the first being the putative transactivator. The gene is predicted to encode a precursor protein of only 53 kDa compared to 70 kDa for simian spumaviruses and a doublet of 70/74 kDa for human spumavirus. The gene contains conserved splice acceptor and donor sites suggesting that, like human foamy virus, FeFV expresses its gene using a spliced mRNA.The and genes showed greater sequence similarity to their counterparts in the primate spumaviruses than the gene and additional open reading frames.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-78-10-2549
1997-10-01
2022-05-28
Loading full text...

Full text loading...

/deliver/fulltext/jgv/78/10/9349476.html?itemId=/content/journal/jgv/10.1099/0022-1317-78-10-2549&mimeType=html&fmt=ahah

References

  1. Achong B. G., Mansell P. W., Epstein M. A., Clifford P. 1971; An unusual virus in cultures from a human nasopharyngeal carcinoma. Journal of the national Cancer Institute 46:299–307
    [Google Scholar]
  2. Bieniasz P. D., Rethwilm A., Pitman R., Daniel M. D., Chrystie I., McClure M. O. 1995; A comparative study of higher primate foamy viruses, including a new virus from a gorilla. Virology 207:217–228
    [Google Scholar]
  3. Bodem J., Lochelt M., Winkler I., Flower R. P., Delius H., Flugel R. M. 1996; Characterization of the spliced pol transcript of feline foamy virus: the splice acceptor site of the pol transcript is located in gag of foamy viruses. Journal of Virology 70:9024–9027
    [Google Scholar]
  4. Flanagan M. 1992; Isolation of a spumavirus from a sheep. Australian Veterinary Journal 69:112–113
    [Google Scholar]
  5. Harbour D. A., Howard P. E., Gaskell R. M. 1991; Isolation of feline calicivirus and feline herpesvirus from domestic cats 1980–1989. Veterinary Record 128:77–80
    [Google Scholar]
  6. He F., Sun J. D., Garrett E. D., Cullen B. R. 1993; Functional organization of the Bel-1 trans activator of human foamy virus. Journal of Virology 67:1896–1904
    [Google Scholar]
  7. Herchenroder O., Renne R., Loncar D., Cobb E. K., Murthy K. K., Schneider J., Mergia A., Luciw P. A. 1994; Isolation, cloning, and sequencing of simian foamy viruses from chimpanzees (SFVcpz): high homology to human foamy virus (HFV). Virology 201:187–199
    [Google Scholar]
  8. Hooks J. J., Gibbs C. J. 1975; The foamy viruses. Bacteriological Reviews 39:169–185
    [Google Scholar]
  9. Hruska J. F., Takemoto K. K. 1975; Biochemical properties of a hamster syncytium-forming (‘foamy’) virus. Journal of the National Cancer Institute 54:601–605
    [Google Scholar]
  10. Kasza L., Hayward A. H. S., Betts A. O. 1969; Isolation of a virus from a cat sarcoma in an established canine melanoma cell line. Research in Veterinary Science 10:216–218
    [Google Scholar]
  11. Keller A., Garrett E. D., Cullen B. R. 1992; The Bel-1 protein of human foamy virus activates human immunodeficiency virus type 1 gene expression via a novel DNA target site. Journal of Virology 66:3946–3949
    [Google Scholar]
  12. Kennedy-Stoskopf S., Stoskopf M. K., Eckhaus M. A., Strandberg J. D. 1986; Isolation of a retrovirus and a herpesvirus from a captive Californian sea lion. Journal of Wildlife Disease 22:156–164
    [Google Scholar]
  13. Kupiec J. J., Kay A., Hayat M., Ravier R., Peries J., Galibert F. 1991; Sequence analysis of the simian foamy virus type 1 genome. Gene 101:185–194
    [Google Scholar]
  14. Lee A. H., Lee K. J., Kim S., Sung Y. C. 1992; Transactivation of human immunodeficiency virus type 1 long terminal repeat-directed gene expression by the human foamy virus bel 1 protein requires a specific DNA sequence. Journal of Virology 66:3236–3240
    [Google Scholar]
  15. Lieber M. M., Benveniste R. E., Sherr C. J., Todaro G. J. 1975; Isolation of type C virus (FS-1) from the European Wildcat (Felis sylvestris). Virology 66:117–127
    [Google Scholar]
  16. Lochelt M., Flugel R. M. 1996; The human foamy virus pol gene is expressed as a Pro-Pol polyprotein and not as a Gag-Pol fusion protein. Journal of Virology 70:1033–1040
    [Google Scholar]
  17. Malmquist W. A., van der Maaten M. J., Boothe A. D. 1969; Isolation, immunodiffusion, immunofluorescence, and electron microscopy of a syncytial virus of lymphosarcomatous and apparently normal cattle. Cancer Research 29:188–200
    [Google Scholar]
  18. Maurer B., Flugel R. M. 1988; Genomic organization of the human spumaretrovirus and its relatedness to AIDS and other retroviruses. AIDS Research And Human Retroviruses 4:467–473
    [Google Scholar]
  19. Maurer B., Bannert H., Darai G., Flugel R. M. 1988; Analysis of the primary structure of the long terminal repeat and the gag and pol genes of the human spumaretrovirus. Journal of Virology 62:1590–1597
    [Google Scholar]
  20. Mergia A., Pratt-Lowe E., Shaw K. E., Renshaw-Gegg L. W., Luciw P. A. 1992; Cis-acting regulatory regions in the long terminal repeat of simian foamy virus type 1. Journal of Virology 66:251–257
    [Google Scholar]
  21. Morozov V. A., Copeland T. D., Nagashima K., Gonda M. A., Oroszlan S. 1997; Protein composition and morphology of human foamy virus intracellular cores and extracellular particles. Virology 228:307–317
    [Google Scholar]
  22. Pedersen N. C., Pool R. R., O’Brien T. 1980; Feline chronic progressive polyarthritis. American Journal of Veterinary Research 41:522–535
    [Google Scholar]
  23. Renne R., Friedl E., Schweizer M., Fleps U., Turek R., Neumann-Haefelin D. 1992; Genomic organization and expression of simian foamy virus type 3 (SFV-3). Virology 186:597–608
    [Google Scholar]
  24. Rethwilm A., Darai G., Rosen A., Maurer B., Flugel R. M. 1987; Molecular cloning of the genome of human spumaretrovirus. Gene 59:19–28
    [Google Scholar]
  25. Rethwilm A., Mori K., Maurer B., ter Meulen V. 1990; Transacting transcriptional activation of human spumaretrovirus LTR in infected cells. Virology 175:568–571
    [Google Scholar]
  26. Riggs J. L., Oshiro L. S., Taylor D. O. N., Lennette E. H. 1969; Syncytium-forming agent isolated from domestic cats. Nature 222:1190–1191
    [Google Scholar]
  27. Russell D. W., Miller A. D. 1996; Foamy virus vectors. Journal of Virology 70:217–222
    [Google Scholar]
  28. Saitou N., Nei M. 1987; The neighbor-joining method: a new method for reconstructing phylogenetic trees. Molecular Biology and Evolution 4:406–425
    [Google Scholar]
  29. Thompson J. D., Higgins D. G., Gibson T. J. 1994; CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positions-specific gap penalties and weight matrix choice. Nucleic Acids Research 22:4673–4680
    [Google Scholar]
  30. Varmus H. 1988; Retroviruses. Science 240:1427–1435
    [Google Scholar]
  31. Venkatesh L. K., Theodorakis P. A., Chinnadurai G. 1991; Distinct cis-acting regions in U3 regulate trans-activation of the human spumaretrovirus long terminal repeat by the viral bel 1 gene product. Nucleic Acids Research 19:3661–3666
    [Google Scholar]
  32. Yoshinaka Y., Katoh I., Copeland T. D., Oroszlan S. 1985; Murine leukemia virus protease is encoded by the gag-pol gene and is synthesized through suppression of an amber termination codon. Proceedings of the National Academy of Sciences USA: 821618–1622
    [Google Scholar]
  33. Yu S. F., Baldwin D. N., Gwynn S. R., Yendapalli S., Linial M. L. 1996a; Human foamy virus replication: a pathway distinct from that of retroviruses and hepadnaviruses. Science 271:1579–1582
    [Google Scholar]
  34. Yu S. F., Edelmann K., Strong R. K., Moebes A., Rethwilm A., Linial M. L. 1996b; The carboxyl terminus of the human foamy virus Gag protein contains separable nucleic acid binding and nuclear transport domains. Journal of Virology 70:8255–8262
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-78-10-2549
Loading
/content/journal/jgv/10.1099/0022-1317-78-10-2549
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error