Nucleotide sequences of regions of the envelope () and polymerase () genes of human immunodeficiency virus type 1 (HIV-1) proviral DNA were obtained from sequential blood and autopsy samples from an AIDS patient who had been treated with zidovudine for 9 months. Phylogenetic analyses showed that a reduction in genetic heterogeneity of the regions of viruses present in the proviral blood population occurred during therapy, and this coincided with an increased gene heterogeneity. Differences were observed in different organs obtained for both the and coding regions. The cardiac blood proviral population consisted mainly of variants which possessed sequences containing mutations at position 215 of the gene, associated with drug resistance. By contrast, the brain population consisted entirely of zidovudine sensitive genotypes, and this organ also harboured variants with genetically distinct sequences. The lymph tissues obtained after death held more diverse proviral and populations, containing both zidovudine sensitive and resistant genotypes.


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