1887

Abstract

Summary

A cDNA clone derived from the mitochondrial cytochrome oxidase I gene has been used to show that the level of mitochondrially encoded RNA species declines during herpes simplex virus type 2 infection in a manner similar to that for RNA species derived from nuclear genes. In contrast to the situation for nuclear genes, however, no change in the transcription rate of the mitochondrial genome during infection was detected, indicating that post-transcriptional processes alone are responsible for the decline in the levels of mitochondrial RNA species during infection. Two stages in this post-transcriptional degradation have been defined, only one of which is dependent upon viral protein synthesis in the infected cell.

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1988-06-01
2024-05-14
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References

  1. AVIV H., LEDER P. 1972; Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid cellulose. Proceedings of the National Academy of Sciences, U.S.A 69:1408–1412
    [Google Scholar]
  2. BASTOW K. E., BOUCHARD J., REN X-J., CHENG Y-C. 1986; Synthesis of dihydrofolate reductase and metabolism of related RNA in a methotrexate resistant human cell line infected with herpes simplex virus type 2. Virology 149:199–207
    [Google Scholar]
  3. BATTEY J., CLAYTON D. A. 1978; The transcription map of mouse mitochondrial DNA. Cell 14:143–156
    [Google Scholar]
  4. BIBB M. J., VAN ETTEN R. A., WRIGHT C. T., WALBERG M. W., CLAYTON D. A. 1981; Sequence and gene organisation of mouse mitochondrial DNA. Cell 26:167–180
    [Google Scholar]
  5. BISHOP J. O., ROSBASH M., EVANS D. J. 1974; Polynucleotide sequences in eukaryotic DNA and RNA that form ribonuclease-resistant complexes with polyuridylic acid. Journal of Molecular Biology 85:75–86
    [Google Scholar]
  6. DUFF R., RAPP F. 1971; Oncogenic transformation of hamster cells after exposure to herpes simplex virus type 2. Nature New Biology 233:48–50
    [Google Scholar]
  7. FAVOLORO J., TREISMAN R., KAMEN R. 1980; Transcriptional maps of polyoma virus-specific RNA: analysis by two-dimensional nuclease S1-gel mapping. Methods in Enzymology 65:718–749
    [Google Scholar]
  8. FEINBERG A. P., VOGELSTEIN B. 1983; A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Analytical Biochemistry 132:6–13
    [Google Scholar]
  9. FENWICK M. L. 1984 The effects of herpes viruses on cellular macromolecular synthesis. Comprehensive Virology 19359–390 Edited by Fraenkel-Conrat H., Wagner R. R. New York & London: Plenum Press;
    [Google Scholar]
  10. FENWICK M. L., MCMENAMIN M. M. 1984; Early virion-associated suppression of cellular protein synthesis by herpes simplex virus is accompanied by inactivation of mRNA. Journal of General Virology 65:1225–1228
    [Google Scholar]
  11. FENWICK M., WALKER M., MARSHALL L. 1980; Some characteristics of an early protein (ICP22) synthesized in cells infected with herpes simplex virus. Journal of General Virology 47:333–341
    [Google Scholar]
  12. GILROY T. E., BENDET A. L., YU J. 1984; A method for analysing transcription using permeabilized cells. Analytical Biochemistry 143:350–360
    [Google Scholar]
  13. HAY R. T., HAY J. 1980; Properties of herpes virus-induced immediate early polypeptides. Virology 104:230–234
    [Google Scholar]
  14. INGLIS S. C. 1982; Inhibition of host protein synthesis and degradation of cellular mRNAs during infection by influenza and herpes simplex virus. Molecular and Cellular Biology 2:1644–1648
    [Google Scholar]
  15. KEMP L. M., BRICKELL P. M., LA THANGUE N. B., LATCHMAN D. S. 1986a; Transcriptional induction of cellular genes during lytic infection with herpes simplex virus. Bioscience Reports 6:945–951
    [Google Scholar]
  16. KEMP L. M., PRESTON C. M., PRESTON V. G., LATCHMAN D. S. 1986b; Cellular gene induction during herpes simplex infection can occur without viral protein synthesis. Nucleic Acids Research 14:9261–9270
    [Google Scholar]
  17. LATCHMAN D. S., ESTRIDGE J. K., KEMP L. M. 1987; Transcriptional induction of the ubiquitin gene during herpes simplex virus infection is dependent upon the viral immediate-early protein ICP4. Nucleic Acids Research 15:7283–7293
    [Google Scholar]
  18. LUND K., ZIOLA B. 1985; Cell sonicates used in the analysis of how measles and herpes simplex type 1 virus infections influence Vero cell mitochondrial calcium uptake. Canadian Journal of Biochemistry and Cell Biology 63:1194–1197
    [Google Scholar]
  19. MACNAB J. C. M. 1987; Herpes simplex virus and human cytomegalovirus: their role in morphological transformation and genital cancers. Journal of General Virology 68:2525–2550
    [Google Scholar]
  20. MACPHERSON I., STOKER M. 1962; Polyoma transformation of hamster cell clones-an investigation of genetic factors affecting cell competence. Virology 16:147–151
    [Google Scholar]
  21. MAYMAN B., NISHIOKA Y. 1985; Differential stability of host mRNAs in Friend erythroleukemia cells infected with herpes simplex virus type 1. Journal of Virology 53:1–6
    [Google Scholar]
  22. MINSON A. C. 1984; Cell transformation and oncogenesis by herpes simplex virus and human cytomegaloviruses. Cancer Surveys 3:91–111
    [Google Scholar]
  23. MURPHY D., BRICKELL P. M., LATCHMAN D. S., WILLISON K., RIGBY P. W. J. 1983; Transcripts regulated during normal embryonic development and oncogenic transformation share a common repetitive element. Cell 35:865–871
    [Google Scholar]
  24. NISHIOKA Y., SILVERSTEIN S. 1977; Degradation of cellular mRNA during infection by herpes simplex virus. Proceedings of the National Academy of Sciences, U.S.A 74:2370–2374
    [Google Scholar]
  25. NISHIOKA Y., SILVERSTEIN S. 1978; Requirement of protein synthesis for the degradation of mRNA in Friend erythroleukemia cells infected with herpes simplex virus type 1. Journal of Virology 27:619–627
    [Google Scholar]
  26. PATEL R., CHAN W. L., KEMP L. M., LA THANGUE N. B., LATCHMAN D. S. 1986; Isolation of cDNA clones derived from a cellular gene transcriptionally induced by herpes simplex virus. Nucleic Acids Research 14:5629–5640
    [Google Scholar]
  27. RADSAK K., ALBRING M. 1974; Herpes simplex virus-induced enhancement of mitochondrial DNA synthesis in the absence of viral replication. Journal of General Virology 25:457–463
    [Google Scholar]
  28. READ G. S., FRENKEL N. 1983; Herpes simplex virus mutants defective in the virion-associated shut off of host polypeptide synthesis and exhibiting abnormal synthesis of immediate early viral polypeptides. Journal of Virology 46:498–512
    [Google Scholar]
  29. SCHECK N., BACHENHEIMER S. L. 1985; Degradation of cellular mRNAs induced by a virion-associated factor during herpes simplex virus infection of vero cells. Journal of Virology 55:601–610
    [Google Scholar]
  30. SCOTT M. R. D., WESTPHAL K.-H., RIGBY P. W. J. 1983; Activation of mouse genes in transformed cells. Cell 34:557–567
    [Google Scholar]
  31. SETH P., RAWLS W. E., DUFF R., RAPP F., MELNICK J. L. 1974; Antigenic differences between isolates of herpes virus. Intervirology 3:1–14
    [Google Scholar]
  32. SHIRAKI K., RAPP F. 1986; Establishment of herpes simplex virus latency in vitro with cycloheximide. Journal of General Virology 67:2497–2500
    [Google Scholar]
  33. STENBERG R., PIZER L. 1982; Herpes simplex virus-induced changes in cellular and adenovirus RNA metabolism in an adenovirus type 5 transformed human cell line. Journal of Virology 42:474–487
    [Google Scholar]
  34. STEVENS J. G. 1975; Latent herpes simplex virus and the nervous system. Current Topics in Microbiology and Immunology 70:31–50
    [Google Scholar]
  35. STROM T., FRENKEL N. 1987; Effects of herpes simplex virus on mRNA stability. Journal of Virology 61:2198–2207
    [Google Scholar]
  36. SYDLSKIS R. J., ROIZMAN B. 1967; The disaggregation of host polyribosomes in productive and abortive infection with herpes simplex virus. Virology 32:678–686
    [Google Scholar]
  37. WAGNER E. K., ROIZMAN B. 1969; Ribonucleic acid synthesis in cells infected with herpes simplex virus. I. Patterns of ribonucleic acid synthesis in productively infected cells. Journal of Virology 4:36–46
    [Google Scholar]
  38. WAHL G. M., STERN M., STARK G. R. 1979; Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl paper and rapid hybridization by using dextran sulfate. Proceedings of the National Academy of Sciences, U.S.A 76:3683–3687
    [Google Scholar]
  39. WILCOX K., SYLANSKYA E. I., KOHN A., ROIZMAN B. 1980; Herpes simplex virus phosphoproteins. Jounal of Virology 33:167–182
    [Google Scholar]
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