1887

Abstract

Summary

A collection of monoclonal antibodies (MAbs) against the haemagglutinin—neuraminidase (HN) and fusion (F) glycoproteins of parainfluenza virus type 3 (PIV3) was used for passive immunization of intracerebrally infected newborn hamsters. A significant degree of protection was obtained with MAbs against both the HN and F viral proteins, but no individual antibody conferred complete protection against disease. MAbs against different epitopes provided different degrees of protection. A MAb to the Sendai virus HN protein was found to confer protection against PIV3 brain infection.

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1988-05-01
2022-01-22
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References

  1. ALSHEIKHLY A.-R., öRVELL C, ANDERSSON T., PERLMANN P. 1985; The role of serologically defined epitopes on mumps virus HN-glycoprotein in the induction of virus dependent cytotoxicity (VDCC). Analysis with monoclonal antibodies. Scandinavian Journal of Immunology 22:529–538
    [Google Scholar]
  2. APPEL M. J. G., GILLESPIE H. J. 1972 Canine distemper virus. Virology Monographs 111–96 Edited by Gard S., Hallauer C., Meyer K. F. Wien: Springer-Verlag;
    [Google Scholar]
  3. CHANOCK R. M., PARROTT R. H., COOK K., ANDREWS B. E., BELL J. A., REICHELDERFER T., KAPIKIAN A. Z., MASTROTA F. M., HUEBNER R. J. 1958; Newly recognized myxoviruses from children with respiratory disease. New England Journal of Medicine 258:207–213
    [Google Scholar]
  4. DIMMOCK N. J. 1984; Mechanisms of neutralization of animal viruses. Journal of General Virology 65:1015–1022
    [Google Scholar]
  5. FULGINITI V. A., ELLER J. J., DOWNIE A. W., KEMPE C. H. 1967; Altered reactivity to measles virus. Atypical measles in children previously immunized with inactivated measles virus vaccines. Journal of the American Medical Association 202:1075–1080
    [Google Scholar]
  6. GLEZEN W. P., LODA F. A., DENNY F. A. 1982 Parainfluenza viruses. Viral Infections of Humans, 2nd ed.441–445 Edited by Evans A. S. New York: Plenum Press;
    [Google Scholar]
  7. KINGSBURY D. W., BRATT M. A., CHOPPIN P. W., HANSON R. P., HOSAKA Y., TER MEULEN V., NORRBY E., PLOWRIGHT W., ROTT R., WUNNER W. H. 1978; Paramyxoviridae. Intervirology 10:137–152
    [Google Scholar]
  8. LEFRANCOIS L. 1984; Protection against lethal viral infection by neutralizing and non-neutralizing monoclonal antibodies: distinct mechanisms of action in vivo. Journal of Virology 51:208–214
    [Google Scholar]
  9. LOVE A., MALM G., RYDBECK R., NORRBY E., KRISTENSSON K. 1985a; Developmental disturbances in the hamster retina caused by a mutant of mumps virus. Developmental Neuroscience 7:65–72
    [Google Scholar]
  10. LOVE A., RYDBECK R., KRISTENSSON K., öRVELL C., NORRBY E. 1985b; Hemagglutinin-neuraminidase glycoprotein as determinant of pathogenicity in mumps virus hamster encephalitis: analysis of mutants selected with monoclonal antibodies. Journal of Virology 53:67–74
    [Google Scholar]
  11. LOVE A., RYDBECK R., LJUNGDAHL Å., KRISTENSSON K., NORRBY E. 1986a; Selection of mutants of mumps virus with altered structure and pathogenicity by passage in vivo. Microbial Pathogenesis 1:149–158
    [Google Scholar]
  12. LOVE A., RYDBECK R., UTTER G., öRVELL C, KRISTENSSON K., NORRBY E. 1986b; Monoclonal antibodies against the fusion protein are protective in necrotizing mumps meningoencephalitis. Journal of Virology 58:220–222
    [Google Scholar]
  13. MOREIN B., SHARP M., SUNDQUIST B., SIMONS K. 1983; Protein subunit vaccines of parainfluenza type 3 virus: immunogenic effect in lambs and mice. Journal of General Virology 64:1557–1569
    [Google Scholar]
  14. MDCHMORE H. G., PARKINSON A. J., HUMPHRIES J. E., SCOTT N. E., MCINTOSH D. A., SCOTT L. V., OOONEY M. K., MILES J. A. R. 1981; Persistent parainfluenza virus shedding during isolation at the South Pole. Nature, London 289:187–189
    [Google Scholar]
  15. NORRBY E., ENDERS-RUCKLE G., TER MEULEN V. 1975; Differences in the appearance of antibodies to structural components of measles virus after immunization with inactivated and live virus. Journal of Infectious Diseases 132:262–269
    [Google Scholar]
  16. öRVELL C., GRANDIEN M. 1982; The effects of monoclonal antibodies on biologic activities of structural proteins of Sendai Virus. Journal of Immunology 129:2779–2787
    [Google Scholar]
  17. öRVELL C, RYDBECK R., LOVE A. 1986; Immunological relationships between mumps virus and parainfluenza viruses studied with monoclonal antibodies. Journal of General Virology 67:1929–1939
    [Google Scholar]
  18. RAMMOHAN K., MCFARLAND H. F., MCFARLLN D. E. 1981; Induction of subacute murine measles encephalitis by monoclonal antibody to virus hemagglutinin. Nature, London 290:588–589
    [Google Scholar]
  19. RAY R., BROWN V. E., COMPANS R. W. 1985; Glycoproteins of human parainfluenza virus type 3: characterization and evaluation as a subunit vaccine. Journal of Infectious Diseases 152:1219–1230
    [Google Scholar]
  20. RUSSELL P. H. 1986; The synergistic neutralization of Newcastle disease virus by two monoclonal antibodies to its haemagglutinin-neuraminidase protein. Archives of Virology 90:135–144
    [Google Scholar]
  21. RYDBECK R., öRVELL C, LöVE A., NORRBY E. 1986; Characterization of four parainfluenza virus type 3 proteins by use of monoclonal antibodies. Journal of General Virology 67:1531–1542
    [Google Scholar]
  22. RYDBECK R., LOVE A., ÖRVELL C., NORRBY E. 1987; Antigenic analysis of human and bovine parainfluenza virus type 3 strains with monoclonal antibodies. Journal of General Virology 68:2153–2160
    [Google Scholar]
  23. SCHMALJOHN A. L., JOHNSON E. D., DALRYMPLE J. M., COLE C. A. 1982; Non-neutralizing monoclonal antibodies can prevent lethal alphavirus encephalitis. Nature, London 297:70–72
    [Google Scholar]
  24. SHIBUTA H., KANDA T., NOZAWA A., SATO S., KUMANISHI T. 1985; Experimental parainfluenza virus infection in mice: growth and spread of a highly pathogenic variant of parainfluenza 3 virus in the mouse brain. Archives of Virology 83:43–52
    [Google Scholar]
  25. WENZEL R. P., MCCORMICK D. P., BEAM W. E. JR 1972; Parainfluenza pneumonia in adults. Journal of the American Medical Association 221:294–295
    [Google Scholar]
  26. WOLINSKY J. S., WAXHAM M. N., SERVER A. C. 1985; Protective effects of glycoprotein-specific monoclonal antibodies on the course of experimental mumps virus meningoencephalitis. Journal of Virology 53:727–734
    [Google Scholar]
  27. YEWDELL J., GERHARD W. 1982; Delineation of four antigenic sites on a paramyxovirus glycoprotein via which monoclonal antibodies mediate distinct antiviral activities. Journal of Immunology 128:2670–2675
    [Google Scholar]
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