1887

Abstract

Summary

The methylation pattern of herpes simplex virus type 1 (HSV-1) DNA, present in the central nervous system of latently infected mice, was examined by digestion of the DNA with methylation-sensitive restriction endonucleases and Southern blot hybridization. Using the enzymes I, I, I and II, the data indicate no extensive methylation of latent HSV-1 DNA . Thus, extensive methylation of the viral genome is not a necessary condition for, or a consequence of maintaining, the latent state .

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/content/journal/jgv/10.1099/0022-1317-68-6-1761
1987-06-01
2019-10-21
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-68-6-1761
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