1887

Abstract

Summary

The methylation pattern of herpes simplex virus type 1 (HSV-1) DNA, present in the central nervous system of latently infected mice, was examined by digestion of the DNA with methylation-sensitive restriction endonucleases and Southern blot hybridization. Using the enzymes I, I, I and II, the data indicate no extensive methylation of latent HSV-1 DNA Thus, extensive methylation of the viral genome is not a necessary condition for, or a consequence of maintaining, the latent state

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1987-06-01
2021-10-28
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