1887

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Volume 68, Issue 12

Deletion and Duplication Variants around the Long Repeats of Herpes Simplex Virus Type 1 Strain 17 Free

Abstract

SUMMARY

Three variants of herpes simplex virus type 1 strain 17 were isolated. One variant had a deletion of 2·5 × 10 in IR/U and 0·8 × 10 in TR such that sequences were deleted from both long repeats. The deletion in U removed the 20K and 22K open reading frames. The second variant had a deletion of 3·5 × 10 in IR/U which again removed the 20K and 22K open reading frames. The third variant had a similar deletion in U, but in this case the deleted sequences were replaced by sequences from the left end of U, such that the long repeat was extended by 3 × 10 and the overall genome size by 2 × 10 All three variants grew almost normally . The analysis of 11 isolates with extensive variation in the long repeats outside the ‘’ sequence is also reported.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): deletion mutants , duplication mutants and HSV-1
© Society for General Microbiology 1987
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1987-12-01
2024-04-26
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Deletion and Duplication Variants around the Long Repeats of Herpes Simplex Virus Type 1 Strain 17
J. Gen. Virol. 68, 3019 (1987); https://doi.org/10.1099/0022-1317-68-12-3019
/content/journal/jgv/10.1099/0022-1317-68-12-3019
/content/journal/jgv/10.1099/0022-1317-68-12-3019
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