%0 Journal Article %A Maclean, Alasdair R. %A Brown, S. Moira %T Deletion and Duplication Variants around the Long Repeats of Herpes Simplex Virus Type 1 Strain 17 %D 1987 %J Journal of General Virology, %V 68 %N 12 %P 3019-3031 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-68-12-3019 %K HSV-1 %K deletion mutants %K duplication mutants %I Microbiology Society, %X SUMMARY Three variants of herpes simplex virus type 1 strain 17 were isolated. One variant had a deletion of 2·5 × 106 M r in IRL/UL and 0·8 × 106 M r in TRL such that sequences were deleted from both long repeats. The deletion in UL removed the 20K and 22K open reading frames. The second variant had a deletion of 3·5 × 106 M r in IRL/UL which again removed the 20K and 22K open reading frames. The third variant had a similar deletion in UL, but in this case the deleted sequences were replaced by sequences from the left end of UL, such that the long repeat was extended by 3 × 106 M r and the overall genome size by 2 × 106 M r All three variants grew almost normally in vitro. The analysis of 11 isolates with extensive variation in the long repeats outside the ‘a’ sequence is also reported. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-68-12-3019