1887

Abstract

Summary

West Nile virus (WNV)-immune spleen cells produced an inducer of macrophage procoagulant activity (MPCA) on restimulation with WNV . This response was specific for WNV and depended on the presence of Thy 1, L3T4 and also Ia cells but not Lyt 2 cells. It could be induced by culture with large amounts of non-infectious, u.v.-irradiated virus or with high doses of infectious virus. Inoculation of mice with low titres of infectious, but not with u.v.-irradiated, virus primed for this response. The time of maximum production of procoagulant-inducing factor was also the period of greatest [H]thymidine uptake and release of interleukin-2 (IL-2)-like activity. In bulk cultures, MPCA-inducing factor was more readily quantified than IL-2. T cells of the helper/delayed-type hypersensitivity class are thus stimulated by WNV and this aspect of cell-mediated immunity can be readily assayed .

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-67-1-39
1986-01-01
2019-10-14
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-67-1-39
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error