1887

Abstract

SUMMARY

Adult female Swiss mice showed a greater resistance to intraperitoneal (i.p.) infection with encephalomyocarditis virus (EMCV) than male mice. This difference was not observed in weanling mice, in castrated adult mice or in adult mice injected intracerebrally. Administration of antibody to mouse interferon α/β enhanced the virulence of EMCV for both sexes and no difference was then observed in susceptibility between male and female mice. Six h after EMCV infection, serum interferon titres were higher in adult female mice than in male mice. There was a close correlation between the early serum interferon titre (at 6 h) and survival of EMCV-infected mice. No differences in serum interferon titres were observed between male or female weanling mice or castrated adult mice. Potent preparations of exogenous interferon provided the same degree of protection against EMCV infection in male and female mice. We conclude that the more marked early interferon response of female mice to i.p. EMCV infection is one of the important factors underlying the differential susceptibility to EMCV. It is possible that the interferon system is also involved in the reported greater prevalence of picornavirus infections of men compared with women.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-66-4-701
1985-04-01
2022-01-28
Loading full text...

Full text loading...

/deliver/fulltext/jgv/66/4/JV0660040701.html?itemId=/content/journal/jgv/10.1099/0022-1317-66-4-701&mimeType=html&fmt=ahah

References

  1. Berkovich S., Ressel M. 1965; Effect of gonadectomy on susceptibility of the adult mouse to Coxsackie B-l virus infection. Proceedings of the Society for Experimental Biology and Medicine 119:690–694
    [Google Scholar]
  2. Berkovich S., Ressel M. 1967; Effect of sex on susceptibility of adult mice to Coxsackie B-l virus infection. Archiv für die gesamte Virusforschung 22:246–251
    [Google Scholar]
  3. Boucher D. W., Hayashi K., Rosenthal J., Notkins A. L. 1975; Virus-induced diabetes mellitus. III. Influence of the sex and strain of the host. Journal of Infectious Diseases 131:462–466
    [Google Scholar]
  4. Demaeyer-Guignard J., Zawatzky R., Dandoy F., Demaeyer E. 1982; An X-linked locus influences the amount of circulating interferon levels in the mouse. Journal of Infectious Diseases 3:241–252
    [Google Scholar]
  5. Engler H., Zawatzky R., Kirchner H., Armerding D. 1982; Experimental infection of inbred mice with herpes simplex virus. IV. Comparison of interferon production and natural killer cell activity in susceptible and resistant adult mice. Archives of Virology 74:239–247
    [Google Scholar]
  6. Frantzen A. 1948; On the preparation of a formalinized aluminium hydroxide vaccine with the murine S. K. poliomyelitis strain (Jungeblut & Sanders). Acta pathologica et microbiologica scandinavica 25:351–355
    [Google Scholar]
  7. Friedman S. B., Grota L. J., Glasgow L. A. 1972; Differential susceptibility of male and female mice to encephalomyocarditis virus: effects of castration, adrenalectomy and the administration of sex hormones. Infection and Immunity 5:637–644
    [Google Scholar]
  8. Giron D. J., Allen P. T., Pindak F. F., Schmidt J. P. 1971a; Inhibition by estrone of the antiviral protection and interferon elicited by interferon inducers in mice. Infection and Immunity 3:318–322
    [Google Scholar]
  9. Giron D. J., Schmidt J. P., Pindak F. F. 1971b; Effect of progesterone and testosterone on interferon production and on the viral infection-enhancing activity of estrone and hydrocortisone. Infection and Immunity 4:537–540
    [Google Scholar]
  10. Gresser I., Bourali C., Thomas M.-T., Falcoff E. 1968; Effect of repeated inoculation of interferon preparations on infection of mice with encephalomyocarditis virus. Proceedings of the Society for Experimental Biology and Medicine 127:491–496
    [Google Scholar]
  11. Gresser I., Fontaine-Brouty-Boye D., Bourali C., Thomas M.-T. 1969; A comparison of the efficacy of endogenous, exogenous and combined endogenous–exogenous interferon in the treatment of mice infected with encephalomyocarditis virus. Proceedings of the Society for Experimental Biology and Medicine 130:236–242
    [Google Scholar]
  12. Gresser I., Tovey M. G., Bandu M.-T., Maury C., Brouty-Boye D. 1976; Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. I. Rapid evolution of encephalomyocarditis virus infection. Journal of Experimental Medicine 144:1305–1315
    [Google Scholar]
  13. Gust I. D., Coulepis A. G., Feinstone S. M., Locarnini S. A., Moritsugu Y., Najera R., Siegl G. 1983; Taxonomic classification of hepatitis A virus. Intervirology 20:1–7
    [Google Scholar]
  14. Huber S. A., Job L. P., Auld K. R., Woodruff J. F. 1981a; Sex-related differences in the rapid production of cytotoxic spleen cells active against uninfected myofibers during Coxsackie virus B-3 infection. Journal of Immunology 126:1336–1340
    [Google Scholar]
  15. Huber S. A., Job L. P., Woodruff J. F. 1981b; Sex-related differences in the pattern of Coxsackie virus B-3 induced immune spleen cell cytotoxicity against virus-infected myofibers. Infection and Immunity 32:68–73
    [Google Scholar]
  16. Huber S. A., Job L. P., Auld K. R. 1982; Influence of sex hormones on Coxsackie B-3 virus infection in Balb/c mice. Cellular Immunology 67:173–189
    [Google Scholar]
  17. Kilbourne E. D., Smart K. M., Pokorny B. A. 1961; Inhibition by cortisone of the synthesis and action of interferon. Nature, London 190:650–651
    [Google Scholar]
  18. McCollum R. W. 1976; Viral hepatitis. In Viral Infections of Humans pp 235–252 Edited by Evans A. S. London: John Wiley & Sons;
    [Google Scholar]
  19. Morens D. M., Zweighaft R. M., Bryan J. M. 1979; Non polio enterovirus disease in the United States. International Journal of Epidemiology 8:49–54
    [Google Scholar]
  20. Nelson D., Hiemstra H., Minor T., D’Alessio D. 1979; Non polio enterovirus activity in Wisconsin based on a 20-year experiment in a diagnostic virology laboratory. American Journal of Epidemiology 109:352–361
    [Google Scholar]
  21. Pedersen E. B., Haahr S., Mogensen S. C. 1983; X-linked resistance of mice to high doses of herpes simplex virus type 2 correlates with early interferon production. Infection and Immunity 142:740–746
    [Google Scholar]
  22. Pizzi M. 1950; Sampling variations of the fifty percent end point determined by the Reed-Muench (Behrens) method. Human Biology 22:151–190
    [Google Scholar]
  23. Reed L. J., Muench H. 1938; A simple method of estimating fifty per cent end points. American Journal of Hygiene 27:493–497
    [Google Scholar]
  24. Stewart W. E. II 1979; The genetics of interferon production. In The Interferon System pp 85–87 Edited by Stewart W. E. II Wien & New York: Springer-Verlag;
    [Google Scholar]
  25. Talas M., Stoger I. 1972; Hormone pretreatment and interferon production in mice. Acta virologica 16:211–216
    [Google Scholar]
  26. Tovey M. G., Begon-Lours J., Gresser I. 1974; A method for the large scale production of potent interferon preparations. Proceedings of the Society for Experimental Biology and Medicine 146:809–815
    [Google Scholar]
  27. Weinstein L. 1957; Influence of age and sex on susceptibility and clinical manifestations in poliomyelitis. New England Journal of Medicine 257:47–52
    [Google Scholar]
  28. Weinstein L., Chang T. W. 1961; Effect of ‘sex’ of tissue cultures on growth of encephalomyocarditis virus. Proceedings of the Society for Experimental Biology and Medicine 108:471–474
    [Google Scholar]
  29. Wong C. Y., Woodruff J. J., Woodruff J. F. 1977; Generation of cytotoxic T lymphocytes during Coxsackie virus B-3 infection. III. Role of sex. Journal of Immunology 119:591–597
    [Google Scholar]
  30. Woodruff J. F. 1980; Viral myocarditis. American Journal of Pathology 101:426–483
    [Google Scholar]
  31. Zawatzky R., Engler H., Kirchner H. 1982a; Experimental infection of inbred mice with herpes simplex virus. III. Comparison between newborn and adult C57BL/6 mice. Journal of General Virology 60:25–29
    [Google Scholar]
  32. Zawatzky R., Gresser I., De Maeyer E., Kirchner H. 1982b; The role of interferon in the resistance of C57B1/6 mice to various doses of herpes simplex virus type 1. Journal of Infectious Diseases 146:405–410
    [Google Scholar]
  33. Zawatzky R., Kirchner H., Demaeyer-Guignard J., Demaeyer E. 1982c; An X-linked locus influences the amount of circulating interferon induced in the mouse by herpes simplex virus type 1. Journal of General Virology 63:325–332
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-66-4-701
Loading
/content/journal/jgv/10.1099/0022-1317-66-4-701
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error