1887

Abstract

SUMMARY

Mice infected with respiratory syncytial virus (RSV) developed cytotoxic lymphocytes in the lungs, which lysed RSV-infected, but not uninfected cells. Cytotoxic activity was greatest 7 to 9 days after infection, was virus-specific, MHC-restricted and abolished by treatment of lymphocytes with anti-Thy 1.2 or with anti-Lyt 2.2 sera and complement. There was a close temporal relationship between the appearance of these cytotoxic lymphocytes in the lung and clearance of virus. In contrast, RSV persisted in the lungs of athymic (nude) mice and such animals failed to develop RSV-specific cytotoxic lymphocytes. Thus, cytotoxic T-cells may have an important role in recovery from RSV infection.

Keyword(s): cytotoxic lymphocytes , lung and RSV
Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-66-12-2533
1985-12-01
2022-01-17
Loading full text...

Full text loading...

/deliver/fulltext/jgv/66/12/JV0660122533.html?itemId=/content/journal/jgv/10.1099/0022-1317-66-12-2533&mimeType=html&fmt=ahah

References

  1. Bancroft G. J., Shellam G. R., Chalmer J. E. 1981; Genetic influences on the augmentation of natural killer (NK) cells during murine cytomegalovirus infection: correlation with patterns of resistance. Journal of Immunology 126:988–994
    [Google Scholar]
  2. Bertotto A., Stagni G., Caprino D., Sonaglia F., Velardi A. 1980; Cell-mediated immunity in RSV bronchiolitis. Journal of Pediatrics 97:334–335
    [Google Scholar]
  3. Bruhn F. W., Yeager A. S. 1977; Respiratory syncytial virus in early infancy. Circulating antibody and the severity of infection. American Journal of Diseases of Children 131:145–148
    [Google Scholar]
  4. Cerottini J.-C., Brunner K. D. 1974; Cell-mediated cytotoxicity, allograft rejection and tumour immunity. Advances in Immunology 18:67–132
    [Google Scholar]
  5. Davies M. D. J., Parrott D. M. V. 1981a; Preparation and purification of lymphocytes from the epithelium and lamina propria of murine small intestine. Gut 22:481–488
    [Google Scholar]
  6. Davies M. D. J., Parrott D. M. V. 1981b; Cytotoxic T cells in small intestine epithelial, lamina propria and lung lymphocytes. Immunology 44:367–371
    [Google Scholar]
  7. Fernie B. F., Ford E. C., Gerin J. L. 1981; The development of Balb/c cells persistently infected with respiratory syncytial virus: presence of ribonucleoprotein on the cell surface. Proceedings of the Society for Experimental Biology and Medicine 167:83–86
    [Google Scholar]
  8. Fulginlti V. A., Eller J. J., Sieber O. F., Joyner J. W., Minamitani M., Meiklejohn G. 1969; Respiratory virus immunization. I. A field trial of two inactivated respiratory virus vaccines; an aqueous trivalent parainfluenza virus vaccine and an alum-precipitated respiratory syncytial virus vaccine. American Journal of Epidemiology 89:435–448
    [Google Scholar]
  9. Glezen W. P., Paredes A., Allison J. E., Taber L. H., Frank A. L. 1981; Risk of respiratory syncytial virus infection for infants from low income families in relationship to age, sex, ethnic group and maternal antibody level. Journal of Pediatrics 98:708–715
    [Google Scholar]
  10. Gottlieb P. D., Marshak-Rothstein A., Auditore-Hargreaves K., Berkoben D. B., August D. A., Rosche R. M., Benedetto J. D. 1980; Construction and properties of new Lyt-congenic strains and anti-Lyt 2.2 and anti-Lyt 3.1 monoclonal antibodies. Immunogenetics 10:545–556
    [Google Scholar]
  11. Kapikian A. Z., Mitchell R. H., Chanock R. M., Shvedoff R. A., Stewart C. E. 1969; An epidemiologic Study of altered clinical reactivity to respiratory syncytial (RS) virus infection in children previously vaccinated with an inactivated RS vaccine. American Journal of Epidemiology 89:405–421
    [Google Scholar]
  12. Kim H. W., Canchola J. G., Brandt C. D., Pyles G., Chanock R. M., Jensen K., Parrott R. H. 1969; Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. American Journal of Epidemiology 89:422–434
    [Google Scholar]
  13. Lamprecht C. L., Krause H. E., Mufson M. A. 1976; Role of maternal antibody in pneumonia and bronchiolitis due to respiratory syncytial virus. Journal of Infectious Diseases 134:211–217
    [Google Scholar]
  14. Luini W., Boraschi D., Alberti S., Aleotti A., Tagliabye A. 1981; Morphological characterization of a cell population responsible for natural killer activity. Immunology 43:663–668
    [Google Scholar]
  15. Ogilvie M. M., Vathenen A. S., Radford M., Codd J., Key S. 1981; Maternal antibody and respiratory syncytial virus infection in infancy. Journal of Medical Virology 7:263–271
    [Google Scholar]
  16. Parrott R. H., Kim H. W., Arrobio J. O., Hodes D. S., Murphy B. R., Brandt C. D., Camargo E., Chanock R. M. 1973; Epidemiology of respiratory syncytial virus infection in Washington, D.C. II. Infection and disease with respect to age, immunologic status, race and sex. American Journal of Epidemiology 98:289–300
    [Google Scholar]
  17. Prince G. A., Horswood R. L., Berndt J., Suffin S. C., Chanock R. M. 1979; Respiratory syncytial virus infection in inbred mice. Infection and Immunity 26:764–766
    [Google Scholar]
  18. Prince G. A., Horswood R. L., Camargo E., Koenig D., Chanock R. M. 1983; Mechanisms of immunity to respiratory syncytial virus in cotton rats. Infection and Immunity 42:81–87
    [Google Scholar]
  19. Scott R., Kaul A., Scott M., Chiba Y., Ogra P. L. 1978; Development of in vitro correlates of cell-mediated immunity to respiratory syncytial virus infections in humans. Journal of Infectious Diseases 137:810–817
    [Google Scholar]
  20. Stott E. J., Taylor O. 1984; Respiratory syncytial virus. A review. Archives of Virology 84:1–52
    [Google Scholar]
  21. Sun C.-S., Wyde P. R., Wilson S. Z., Knight V. 1983a; Cell-mediated cytotoxic responses in lungs of cotton rats infected with respiratory syncytial virus. American Review of Respiratory Diseases 127:460–464
    [Google Scholar]
  22. Sun C.-S., Wyde P. R., Knight V. 1983b; Correlation of cytotoxic activity in lungs to recovery of normal and gamma-irradiated cotton rats from respiratory syncytial virus infection. American Review of Respiratory Diseases 128:668–672
    [Google Scholar]
  23. Taylor G., Stott E. J., Bew M., Fernie B. F., Cote P. J., Collins A. P., Hughes M., Jebbett J. 1984a; Monoclonal antibodies protect against respiratory syncytial virus infection in mice. Immunology 52:137–142
    [Google Scholar]
  24. Taylor G., Stott E. J., Hughes M., Collins A. P. 1984b; Respiratory syncytial virus infection in mice. Infection and Immunity 43:649–655
    [Google Scholar]
  25. Walsh E. E., Schlesinger J. J., Brandriss M. W. 1984; Protection from respiratory syncytial virus infection in cotton rats by passive transfer of monoclonal antibodies. Infection and Immunity 43:756–758
    [Google Scholar]
  26. Ward K. A., Lambden P. R., Ogilvie M. M., Watt P. J. 1983; Antibodies to respiratory syncytial virus polypeptides and their significance in human infection. Journal of General Virology 64:1867–1876
    [Google Scholar]
  27. Wyde P. R., Sun C.-S., Knight V. 1983; Replication of respiratory syncytial virus in lungs of immunodeficient mice. Journal of the Reticuloendothelial Society 34:125–129
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-66-12-2533
Loading
/content/journal/jgv/10.1099/0022-1317-66-12-2533
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error