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F-IFr cells, which are more resistant to the anticellular and antiviral action of human α and β interferons (IFN-α and IFN-β) than the parental RSa cells, were also found to be more resistant to both the anticellular and antiviral effect of IFN-γ. A high level of 2–5A synthetase was induced by treatment with IFN-α or -β, but induction of 2–5A synthetase was not detected after IFN-γ treatment of the cells. F-IFr cells had less than half the number of specific binding sites for IFN-α than the parental RSa cells.
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