1887

Abstract

SUMMARY

The alteration in the DNA sequence responsible for the mutant phenotype of the herpes simplex virus type 1 temperature-sensitive mutant K has been determined. A single C:G base pair present in the wild-type Vmw 175 immediate-early polypeptide-coding sequence has been replaced by T:A in the mutant gene. This results in the substitution of an alanine by a valine codon. In two revertants the mutant T:A base pair has been resubstituted by C:G.

Keyword(s): HSV-1 ts K , marker rescue and Vmw 175
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/content/journal/jgv/10.1099/0022-1317-65-5-859
1984-05-01
2023-02-04
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