1887

Abstract

SUMMARY

The restriction endonuclease (RE) cleavage patterns of the DNA of herpes simplex virus (HSV) genital isolates from two geographically distinct groups and from one group of facial isolates were examined. Eleven of 21 genital isolates from females, 1 of 27 genital isolates from males and all 17 of the facial isolates were HSV type 1 (HSV-1). The groups of isolates of the same serotype could not be distinguished by significant differences in the frequency of variable restriction endonuclease sites or molecular weight of variable length fragments. Simultaneous consideration of two or more variable sites has disclosed some which are apparently correlated in the HSV-1 isolates, and which could provide a useful marker for phylogenetic relationships. However, most pairs showed no correlation, while certain sites appeared more closely correlated in the genital than in the facial isolates. All 39 HSV-2 isolates could be distinguished from each other on the basis of a combination of variable RE sites and variable length fragments. II RE sites appeared less variable than other RE sites.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-64-2-357
1983-02-01
2022-01-20
Loading full text...

Full text loading...

/deliver/fulltext/jgv/64/2/JV0640020357.html?itemId=/content/journal/jgv/10.1099/0022-1317-64-2-357&mimeType=html&fmt=ahah

References

  1. Adams J., Rothman E. D. 1982; Estimation of phylogenetic relationships from DNA restriction patterns and selection of endonuclease cleavage sites. Proceedings of the National Academy of Sciences of the United States of America 79:3560–3564
    [Google Scholar]
  2. Amstey M. S., Balduzzi P. C. 1970; Genital herpesvirus (type II) strain differences. American Journal of Obstetrics and Gynecology 106:924–927
    [Google Scholar]
  3. Brown M. 1980; Polymorphism in mitochondrial DNA of humans as revealed by restriction endonuclease analysis. Proceedings of the National Academy of Sciences of the United States of America 77:3605–3609
    [Google Scholar]
  4. Brown S. M., Ritchie D. A., Subak-Sharpe J. H. 1973; Genetic studies with HSV-1. Isolation of temperature sensitive mutants, their arrangement into complementation groups and Recombination analysis leading to a linkage map. Journal of General Virology 18:329–346
    [Google Scholar]
  5. Buchman T. G., Roizman B., Adams G., Stover B. H. 1978; Restriction endonuclease fingerprinting of herpes simplex virus DNA: a novel epidemiological tool applied to a nosocomial outbreak. Journal of Infectious Diseases 138:488–498
    [Google Scholar]
  6. Buchman T. G., Simpson T., Nosal C., Roizman B. 1980; The structure of herpes simplex virus DNA and its application to molecular epidemiology. Annals of the New York Academy of Sciences 354:279–290
    [Google Scholar]
  7. Chang T.-W. 1977; Genital herpes and type 1 herpesvirus. Journal of the American Medical Asssociation 238:155
    [Google Scholar]
  8. Chang T.-W., Fiumara N. J., Weinstein L. 1974; Genital herpes. Some clinical and laboratory observations. Journal of the American Medical Association 229:544–545
    [Google Scholar]
  9. Clements J. B., Cortini R., Wilkie N. M. 1976; Analysis of HSV substructure by means of restriction endonucleases. Journal of General Virology 30:243–256
    [Google Scholar]
  10. Cortini R., Wilkie N. M. 1978; Physical maps for HSV type 2 DNA with five restriction endonucleases. Journal of General Virology 39:259–280
    [Google Scholar]
  11. Davison A. J., Wilkie N. M. 1981; Nucleotide sequences of the joint between the L and S segments of herpes simplex virus types I and II. Journal of General Virology 55:315–331
    [Google Scholar]
  12. Delius H., Clements J. B. 1976; A partial denaturation map of HSV type 1 DNA: evidence for inversion of the unique DNA regions. Journal of General Virology 33:125–133
    [Google Scholar]
  13. Denaro M., Blanc H., Johnson M. J., Chen K. H., Wilmsen E., Cavalli-Sforza L. L., Wallace D. C. 1981; Ethnic variation in Hpa I endonuclease cleavage patterns of human mitochondrial DNA. Proceedings of the National Academy of Sciences of the United States of America 78:5768–5772
    [Google Scholar]
  14. Dowdle W. R., Nahmias A. J., Harwell R. W., Pauls F. P. 1967; Association of antigenic types of herpesvirus hominis to site of viral recovery. Journal of Immunology 99:974–980
    [Google Scholar]
  15. Dundarov S., Andonov P., Bakalov B. 1980; Characteristics of herpes simplex virus strains isolated from patients with various diseases. Archives of Virology 63:115–121
    [Google Scholar]
  16. Eglin R. P., Sharp F., Maclean A. B., Macnab J. C. M., Clements J. B., Wilkie N. M. 1981; Detection of RNA complementary to herpes simplex virus DNA in human cervical squamous cell neoplasms. Cancer Research 41:3597–3603
    [Google Scholar]
  17. Hayward G. S., Frenkel N., Roizman B. 1975; Anatomy of HSV DNA: strain differences and heterogeneity in the location of restriction endonuclease cleavage sites. Proceedings of the National Academy of Sciences of the United States of America 72:1768–1772
    [Google Scholar]
  18. Kan Y. W., Lee K. Y., Furbetta M., Angius A., Antonio C. 1980; Polymorphism of DNA sequence in the β-globin gene region. New England Journal of Medicine 302:185–188
    [Google Scholar]
  19. Locker H., Frenkel N. 1979; Bam HI, Kpn I and Sal I restriction enzyme maps of the DNA of herpes simplex virus strains Justin and F: occurrence of heterogeneities in defined regions of the DNA. Journal of Virology 32:429–441
    [Google Scholar]
  20. Lonsdale D. M. 1979; A rapid technique for distinguishing herpes simplex virus type 1 from type 2 by restriction enzyme technology. Lancet 21:849–851
    [Google Scholar]
  21. Lonsdale D. M., Brown S. M., Subak-Sharke J. H., Warren K. G., Koprowski H. 1979; The polypeptide and the DNA restriction enzyme profiles of spontaneous isolates of herpes simplex virus type 1 from explants of human trigeminal, superior cervical and vagus ganglia. Journal of General Virology 43:151–171
    [Google Scholar]
  22. Lonsdale D. M., Brown S. M., Lang J., Subak-Sharpe J. H., Koprowski H., Warren K. G. 1980; Variation in HSV isolated from human ganglion and a clonal variation in HSV-1. Annals of the New York Academy of Sciences 354:291–308
    [Google Scholar]
  23. McDougall J. K., Galloway D. A., Fenoglio C. M. 1980; Cervical carcinoma: detection of herpes simplex virus RNA in cells undergoing neoplastic change. International Journal of Cancer 25:1–8
    [Google Scholar]
  24. Naib Z. M., Nahmias A. J., Josey W. E., Kramer J. H. 1969; Genital herpetic infection: association with cervical dysplasia and carcinoma. Cancer 23:940–945
    [Google Scholar]
  25. Pereira L., Cassai E., Honess R. W., Roizman B., Terni M., Nahmias A. J. 1976; Variability in the structural polypeptides of HSV-1 strains: potential application in molecular epidemiology. Infection and Immunity 13:211–220
    [Google Scholar]
  26. Peutherer J. F., Smith I. W., Hunter J. M. 1981; Herpes simplex virus 1 infection of the cervix. Lancet i:1285
    [Google Scholar]
  27. Rawls W. E., Bacchetti S., Graham F. L. 1977; Relation of herpes simplex viruses to human malignancies. Current Topics in Microbiology and Immunology 77:71–95
    [Google Scholar]
  28. Sanders P. G., Wilkie N. M., Davison A. J. 1982; Thymidine kinase deletion mutants of herpes simplex virus type 1. Journal of General Virology 63:277–295
    [Google Scholar]
  29. Seth P., Rawls W. E., Duff R., Rapp F., Adam E., Melnick J. L. 1974; Antigenic difference between isolates of HSV-2. Intervirology 3:1–14
    [Google Scholar]
  30. Sheldrick P., Berthelot N. 1974; Inverted repetition in the genome of herpes simplex virus. Cold Spring Harbor Symposia on Quantitative Biology 39:667–678
    [Google Scholar]
  31. Skare J., Summers W. P., Summers W. C. 1975; Structure and function of HSV genomes. I. Comparison of 5 HSV-1 and 2 HSV-2 strains by cleavage of their DNA with Eco RI restriction endonuclease. Journal of Virology 15:726–732
    [Google Scholar]
  32. Terni M., Roizman B. 1970; Variability of HSV. Isolation of two variants from simultaneous eruptions at different sites. Journal of Infectious Diseases 121:212–216
    [Google Scholar]
  33. Timbury M. C. 1971; Temperature sensitive mutants of herpes simplex virus type 2. Journal of General Virology 13:373–376
    [Google Scholar]
  34. Wagner M. J., Summers W. C. 1978; Structure of the joint region and the termini of DNA of herpes simplex virus type 1. Journal of Virology 27:374–387
    [Google Scholar]
  35. Wilkie N. M. 1976; Physical maps for HSV-1 DNA for restriction endonucleases HindIII HpaIII and Xba. Journal of Virology 20:222–233
    [Google Scholar]
  36. Wilkie N. M., Cortini R. 1976; Sequence arrangement in HSV type 1 DNA. Identification of terminal fragments in RE digests and evidence for inversion in redundant and unique sequences. Journal of Virology 20:211–221
    [Google Scholar]
  37. Wilkie N. M., Davison A., Chartrand P., Stow N. D., Preston V. G., Timbury M. C. 1978; Recombination in HSV: mapping of mutation and analysis of intertypic Recombinants. Cold Spring Harbor Symposia on Quantitative Biology 43:827–840
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-64-2-357
Loading
/content/journal/jgv/10.1099/0022-1317-64-2-357
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error