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DNA was extracted from varicella-zoster (VZ) virions prepared in sucrose gradients. Thirty-eight molecules examined by electron microscopy were found to have a mean length of 46.7 µm. Examination of self-annealed VZV DNA molecules revealed that the virus genome was composed of a unique linear large sequence with a mol. wt. of 74.4 × 106 to 78.4 × 106, and a unique short sequence of mol. wt. approx. 9.8 × 106 flanked by inverted repeat sequences of 4.7 × 106 mol. wt.
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