1887

Abstract

SUMMARY

The genetic composition of several recombinant strains, produced by mixed infection with an amantadine-sensitive and an amantadine-resistant influenza virus, have been compared with their response to amantadine. It is concluded that transfer of resistance or sensitivity to amantadine is determined by a single gene, that coding for the matrix protein.

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1979-01-01
2023-01-29
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References

  1. Appleyard G. 1977; Amantadine-resistance as a genetic marker for influenza viruses. Journal of General Virology 36:249–255
    [Google Scholar]
  2. Cochran K. W., Maassab H. R., Tsunoda A., Berlin B. S. 1965; Studies on the antiviral activity of amantadine hydrochloride. Annals of the New York Academy of Sciences 130:432–439
    [Google Scholar]
  3. Davies W. L., Grunert R. R., Haff R. F., McGahen J. W., Neumayer E. M., Paulshock M., Watts J. C., Wood T. R., Herrmann E. C., Hoffman C. E. 1964; Antiviral activity of 1-adamantanamine (amantadine). Science 144:862–863
    [Google Scholar]
  4. Dourmashkin R. R., Tyrrell D. A. J. 1974; Electron microscopic observations on the entry of influenza virus into susceptible cells. Journal of General Virology 24:129–141
    [Google Scholar]
  5. Hay A. J., Bellamy A. R., Abraham G., Skehel J. J., Brand C. M., Webster R. G. 1977a; Procedures for characterisation of the genetic material of candidate vaccine strains. In International Symposium on Influenza Immunization vol II Geneva 1977. Developments in Biological Standardization, vol. 39 pp 15–24 Basel: S. Karger;
    [Google Scholar]
  6. Hay A. J., Lomniczi B., Bellamy A. R., Skehel J. J. 1977b; Transcription of the influenza virus genome. Virology 83:337–355
    [Google Scholar]
  7. Hoffmann C. E., Neumayer E. M., Haff R. F., Goldsby R. A. 1965; Mode of action of the antiviral activity of amantadine in tissue culture. Journal of Bacteriology 90:623–628
    [Google Scholar]
  8. Kato N., Eggers H. J. 1969; Inhibition of uncoating of fowl plague virus by 1-adamantanamine hydrochloride. Virology 37:632–641
    [Google Scholar]
  9. Neumayer E. M., Haff R. F., Hoffmann C. E. 1965; Antiviral activity of amantadine hydrochloride in tissue culture and in ovo. Proceedings of the Society for Experimental Biology and Medicine 119:393–396
    [Google Scholar]
  10. Oxford J. S., Potter C. W., Logan I. S. 1970; Passage of influenza strains in the presence of amino-adamantane. Annals of the New York Academy of Sciences 173:300–313
    [Google Scholar]
  11. Ritchey M. B., Palese P., Schulman J. L. 1976; Mapping of the influenza virus genome.III. Identification of genes coding for nucleoprotein, membrane protein and nonstructural protein. Journal of Virology 20:307–317
    [Google Scholar]
  12. Skehel J. I., Hay A. J., Armstrong J. A. 1978; On the mechanism of inhibition of influenza virus replication by amantadine hydrochloride. Journal of General Virology 38:97–110
    [Google Scholar]
  13. Tuckova E., Vonka V., Zavadova A., Kutinova L. 1973; Sensitivity to 1-adamantanamine as a marker in genetic studies wth influenza viruses. Journal of Biological Standardization 1:341–346
    [Google Scholar]
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