The Matrix Protein Gene Determines Amantadine-Sensitivity of Influenza Viruses

A. J. Hay; N. C. T. Kennedy; J. J. Skehel; G. Appleyard

doi:10.1099/0022-1317-42-1-189

The Matrix Protein Gene Determines Amantadine-Sensitivity of Influenza Viruses

A. J. Hay, N. C. T. Kennedy, J. J. Skehel and G. Appleyard
First Published: 01 January 1979 https://doi.org/10.1099/0022-1317-42-1-189

Abstract

Summary

The genetic composition of several recombinant strains, produced by mixed infection with an amantadine-sensitive and an amantadine-resistant influenza virus, have been compared with their response to amantadine. It is concluded that transfer of resistance or sensitivity to amantadine is determined by a single gene, that coding for the matrix protein.

Received: 29/06/1978
Accepted: 28/07/1978
Published Online: 01/01/1979

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Journal of General Virology

Volume 42, Issue 1

Research Article

Free

The Matrix Protein Gene Determines Amantadine-Sensitivity of Influenza Viruses

Abstract

Most read this month

Most cited this month Most Cited RSS feed

Mechanisms and enzymes involved in SARS coronavirus genome expression

Cyclosporin A inhibits the replication of diverse coronaviruses

Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment

Virus-encoded proteinases and proteolytic processing in the Nidovirales

MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

Interferon-β and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays

ICTV Virus Taxonomy Profile: Picornaviridae

ICTV Virus Taxonomy Profile: Flaviviridae

Characteristics of the Microplate Method of Enzyme-Linked Immunosorbent Assay for the Detection of Plant Viruses