The Matrix Protein Gene Determines Amantadine-Sensitivity of Influenza Viruses

A. J. Hay; N. C. T. Kennedy; J. J. Skehel; G. Appleyard

doi:10.1099/0022-1317-42-1-189

The Matrix Protein Gene Determines Amantadine-Sensitivity of Influenza Viruses

A. J. Hay, N. C. T. Kennedy, J. J. Skehel and G. Appleyard
First Published: 01 January 1979 https://doi.org/10.1099/0022-1317-42-1-189

Abstract

Summary

The genetic composition of several recombinant strains, produced by mixed infection with an amantadine-sensitive and an amantadine-resistant influenza virus, have been compared with their response to amantadine. It is concluded that transfer of resistance or sensitivity to amantadine is determined by a single gene, that coding for the matrix protein.

Received: 29/06/1978
Accepted: 28/07/1978
Published Online: 01/01/1979

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-42-1-189

1979-01-01

2019-11-13

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-42-1-189

Most Cited This Month

- Characteristics of the Microplate Method of Enzyme-Linked Immunosorbent Assay for the Detection of Plant Viruses
  
  M. F. Clark and A. N. Adams
- Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5
  
  F. L. Graham, J. Smiley, W. C. Russell and R. Nairn
- Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures
  
  Richard E. Randall and Stephen Goodbourn
- Typing hepatitis C virus by polymerase chain reaction with type-specific primers: application to clinical surveys and tracing infectious sources
  
  Hiroaki Okamoto, Yasushi Sugiyama, Shunichi Okada, Kiyohiko Kurai, Yoshihiro Akahane, Yoshiki Sugai, Takeshi Tanaka, Koei Sato, Fumio Tsuda, Yuzo Miyakawa and Makoto Mayumi
- Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region
  
  P. Simmonds, E. C. Holmes, T.-A. Cha, S.-W. Chan, F. McOmish, B. Irvine, E. Beall, P. L. Yap, J. Kolberg and M. S. Urdea
- The use of general primers GP5 and GP6 elongated at their 3′ ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR
  
  Ana-Maria de Roda Husman, Jan M. M. Walboomers, Adriaan J. C. van den Brule, Chris J. L. M. Meijer and Peter J. F. Snijders
- The Complete DNA Sequence of the Long Unique Region in the Genome of Herpes Simplex Virus Type 1
  
  D. J. McGeoch, M. A. Dalrymple, A. J. Davison, A. Dolan, M. C. Frame, D. McNab, L. J. Perry, J. E. Scott and P. Taylor
- The Complete DNA Sequence of Varicella-Zoster Virus
  
  Andrew J. Davison and James E. Scott
- Typing Hepatitis B Virus by Homology in Nucleotide Sequence: Comparison of Surface Antigen Subtypes
  
  Hiroaki Okamoto, Fumio Tsuda, Hiroshi Sakugawa, Retno I. Sastrosoewignjo, Mitsunobu Imai, Yuzo Miyakawa and Makoto Mayumi
- The multifunctional NS1 protein of influenza A viruses
  
  Benjamin G. Hale, Richard E. Randall, Juan Ortín and David Jackson
More Less

Journal of General Virology

Volume 42, Issue 1

Research Article

Free

The Matrix Protein Gene Determines Amantadine-Sensitivity of Influenza Viruses

Abstract

Most Read This Month

Most Cited This Month

Characteristics of the Microplate Method of Enzyme-Linked Immunosorbent Assay for the Detection of Plant Viruses

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures

Typing hepatitis C virus by polymerase chain reaction with type-specific primers: application to clinical surveys and tracing infectious sources

Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region

The use of general primers GP5 and GP6 elongated at their 3′ ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR

The Complete DNA Sequence of the Long Unique Region in the Genome of Herpes Simplex Virus Type 1

The Complete DNA Sequence of Varicella-Zoster Virus

Typing Hepatitis B Virus by Homology in Nucleotide Sequence: Comparison of Surface Antigen Subtypes

The multifunctional NS1 protein of influenza A viruses