The Matrix Protein Gene Determines Amantadine-Sensitivity of Influenza Viruses

A. J. Hay; N. C. T. Kennedy; J. J. Skehel; G. Appleyard

doi:10.1099/0022-1317-42-1-189

The Matrix Protein Gene Determines Amantadine-Sensitivity of Influenza Viruses

A. J. Hay, N. C. T. Kennedy, J. J. Skehel and G. Appleyard
First Published: 01 January 1979 https://doi.org/10.1099/0022-1317-42-1-189

Abstract

Summary

The genetic composition of several recombinant strains, produced by mixed infection with an amantadine-sensitive and an amantadine-resistant influenza virus, have been compared with their response to amantadine. It is concluded that transfer of resistance or sensitivity to amantadine is determined by a single gene, that coding for the matrix protein.

Received: 29/06/1978
Accepted: 28/07/1978
Published Online: 01/01/1979

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-42-1-189

1979-01-01

2021-08-05

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-42-1-189

Most cited this month Most Cited RSS feed

- Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5
  
  F. L. Graham, J. Smiley, W. C. Russell and R. Nairn
- The Complete DNA Sequence of the Long Unique Region in the Genome of Herpes Simplex Virus Type 1
  
  D. J. McGeoch, M. A. Dalrymple, A. J. Davison, A. Dolan, M. C. Frame, D. McNab, L. J. Perry, J. E. Scott and P. Taylor
- The Complete DNA Sequence of Varicella-Zoster Virus
  
  Andrew J. Davison and James E. Scott
- Characterization of Herpes Simplex Virus Strains Differing in their Effects on Social Behaviour of Infected Cells
  
  Pilarica M. Ejercito, E. D. Kieff and B. Roizman
- Structure, Replication, and Recombination of Retrovirus Genomes: Some Unifying Hypotheses
  
  John M. Coffin
- Genetic Studies with Herpes Simplex Virus Type 1. The Isolation of Temperature-sensitive Mutants, their Arrangement into Complementation Groups and Recombination Analysis Leading to a Linkage Map
  
  S. Moira Brown, D. A. Ritchie and J. H. Subak-Sharpe
- Isolation and Characterization of a Herpes Simplex Virus Type 1 Mutant Containing a Deletion within the Gene Encoding the Immediate Early Polypeptide Vmw110
  
  Nigel D. Stow and Elizabeth C. Stow
- Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region
  
  P. Simmonds, E. C. Holmes, T.-A. Cha, S.-W. Chan, F. McOmish, B. Irvine, E. Beall, P. L. Yap, J. Kolberg and M. S. Urdea
- The Products of Herpes Simplex Virus Type 1 (HSV-1) Immediate Early Genes 1, 2 and 3 Can Activate HSV-1 Gene Expression in trans
  
  R. D. Everett
- Characterization of the IE110 Gene of Herpes Simplex Virus Type 1
  
  Lise J. Perry, Frazer J. Rixon, Roger D. Everett, Margaret C. Frame and Duncan J. McGeoch
More Less

Journal of General Virology

Volume 42, Issue 1

Research Article

Free

The Matrix Protein Gene Determines Amantadine-Sensitivity of Influenza Viruses

Abstract

Most read this month

Most cited this month Most Cited RSS feed

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

The Complete DNA Sequence of the Long Unique Region in the Genome of Herpes Simplex Virus Type 1

The Complete DNA Sequence of Varicella-Zoster Virus

Characterization of Herpes Simplex Virus Strains Differing in their Effects on Social Behaviour of Infected Cells

Structure, Replication, and Recombination of Retrovirus Genomes: Some Unifying Hypotheses

Genetic Studies with Herpes Simplex Virus Type 1. The Isolation of Temperature-sensitive Mutants, their Arrangement into Complementation Groups and Recombination Analysis Leading to a Linkage Map

Isolation and Characterization of a Herpes Simplex Virus Type 1 Mutant Containing a Deletion within the Gene Encoding the Immediate Early Polypeptide Vmw110

Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region

The Products of Herpes Simplex Virus Type 1 (HSV-1) Immediate Early Genes 1, 2 and 3 Can Activate HSV-1 Gene Expression in trans

Characterization of the IE110 Gene of Herpes Simplex Virus Type 1