The Matrix Protein Gene Determines Amantadine-Sensitivity of Influenza Viruses

A. J. Hay; N. C. T. Kennedy; J. J. Skehel; G. Appleyard

doi:10.1099/0022-1317-42-1-189

The Matrix Protein Gene Determines Amantadine-Sensitivity of Influenza Viruses

A. J. Hay, N. C. T. Kennedy, J. J. Skehel and G. Appleyard
First Published: 01 January 1979 https://doi.org/10.1099/0022-1317-42-1-189

Abstract

Summary

The genetic composition of several recombinant strains, produced by mixed infection with an amantadine-sensitive and an amantadine-resistant influenza virus, have been compared with their response to amantadine. It is concluded that transfer of resistance or sensitivity to amantadine is determined by a single gene, that coding for the matrix protein.

Received: 29/06/1978
Accepted: 28/07/1978
Published Online: 01/01/1979

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Journal of General Virology

Volume 42, Issue 1

Research Article

Free

The Matrix Protein Gene Determines Amantadine-Sensitivity of Influenza Viruses

Abstract

Most read this month

Most cited this month Most Cited RSS feed

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Mechanisms and enzymes involved in SARS coronavirus genome expression

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ICTV Virus Taxonomy Profile: Geminiviridae

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Virus-encoded proteinases and proteolytic processing in the Nidovirales

Updated classification of norovirus genogroups and genotypes

ICTV Virus Taxonomy Profile: Flaviviridae