%0 Journal Article %A Hay, A. J. %A Kennedy, N. C. T. %A Skehel, J. J. %A Appleyard, G. %T The Matrix Protein Gene Determines Amantadine-Sensitivity of Influenza Viruses %D 1979 %J Journal of General Virology, %V 42 %N 1 %P 189-191 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-42-1-189 %I Microbiology Society, %X SUMMARY The genetic composition of several recombinant strains, produced by mixed infection with an amantadine-sensitive and an amantadine-resistant influenza virus, have been compared with their response to amantadine. It is concluded that transfer of resistance or sensitivity to amantadine is determined by a single gene, that coding for the matrix protein. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-42-1-189