1887

Abstract

Summary

Studies of the resistance patterns to infection with a murine cytomegalovirus in inbred strains of mice revealed the existence of resistant and susceptible strains. Resistance was found to be associated with possession of the H-2 allele at the major histocompatibility locus of the mouse. The F hybrid between a resistant strain (C3H/HeJ) and a susceptible strain (BALB/c) was found to have a resistance intermediate between that of both parents, indicating that the gene(s) controlling resistance is partly dominant. Susceptible BALB/c mice could be made resistant to lethal infection by pre-treatment with thioglycollate broth but not by pre-treatment with endotoxin or BCG. Resistant C3H/HeJ mice could be made susceptible to lethal infection by pre-treatment with cyclophosphamide.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-37-1-107
1977-10-01
2021-10-17
Loading full text...

Full text loading...

/deliver/fulltext/jgv/37/1/JV0370010107.html?itemId=/content/journal/jgv/10.1099/0022-1317-37-1-107&mimeType=html&fmt=ahah

References

  1. Allison A. C. 1974; On the role of mononuclear phagocytes in immunity against viruses. Progress in Medical Virology 18:15–31
    [Google Scholar]
  2. Babiuk L. A., Rouse B. T. 1976; Immune interferon production by lymphoid cells: role in the inhibition of herpesviruses. Infection and Immunity 13:1567–1587
    [Google Scholar]
  3. Bang F. B., Warwick A. 1960; Mouse macrophages as host cells for the mouse hepatitis virus and the genetic basis of their susceptibility. Proceedings of the National Academy of Sciences of the United States of America 46:1065–1075
    [Google Scholar]
  4. Baron S. 1970; The defensive role of the interferon system. Journal of General Physiology 56:193S–211S
    [Google Scholar]
  5. Berenbaum M. C., Brown I. N. 1964; Dose-response relationships for agents inhibiting the immune response. Immunology 7:65–71
    [Google Scholar]
  6. De Maeyer E., De Maeyer-Guignard J. 1968; Influence of animal genotype and age on the amount of circulatory interferon induced by Newcastle Disease virus. Journal of General Virology 2:445–449
    [Google Scholar]
  7. Gadeberg O. V., Rhodes J. M., Larson S. O. 1975; The effect of various immunosuppressive agents on mouse peritoneal macrophages and on the in vitro phagocytosis of Escherichia coli 04:K3:H5 and degradation of 125I-labelled HSA-antibody complexes by these cells. Immunology 28:59–70
    [Google Scholar]
  8. Glasgow L. A., Hanshaw J. B., Merigan T. C., Petralli J. K. 1967; Interferon and cytomegalovirus in vivo and in vitro. Proceedings of the Society for Experimental Biology and Medicine 125:843–849
    [Google Scholar]
  9. Günther E. 1973; A brief review of immune-response genes in mice. Transplantation Proceedings 5:1315–1319
    [Google Scholar]
  10. Haahr S., Rasmussen L., Merigan T. C. 1976; Lymphocyte transformation and interferon production in human mononuclear cell microcultures for assay of cellular immunity to herpes simplex virus. Infection and Immunity 14:47–54
    [Google Scholar]
  11. Hanshaw J. B. 1968; Cytomegaloviruses. Virology Monographs 3:1–23
    [Google Scholar]
  12. Howard R. J., Miller J., Najarian J. S. 1974; Cytomegalovirus-induced immune suppression. Ⅱ. Cell-mediated immunity. Clinical and Experimental Immunology 18:119–126
    [Google Scholar]
  13. Howard R. I., Najarian J. S. 1974; Cytomegalovirus-induced immune suppression. I. Humoral immunity. Clinical and Experimental Immunology 18:109–118
    [Google Scholar]
  14. Longenecker B. M., Pazderka F., Gavora J. S., Spencer J. L., Ruth R. F. 1976; Lymphoma induced by herpesvirus: resistance associated with a major histocompatibility gene. Immunogenetics 3:401–407
    [Google Scholar]
  15. Lopez C. 1975; Genetics of natural resistance to herpesvirus infections in mice. Nature, London 258:152–153
    [Google Scholar]
  16. Mannini A. Jun, Medearis D. N. 1961; Mouse salivary gland virus infections. American Journal of Hygiene 73:329–343
    [Google Scholar]
  17. Mims C. A. 1964; Aspects of the pathogenesis of virus diseases. Bacteriological Reviews 28:30–71
    [Google Scholar]
  18. Oie H. K., Easton J. M., Ablashi D. V., Baron S. 1975; Murine cytomegalovirus: induction of and sensitivity to interferon in vitro. Infection and Immunity 12:1012–1017
    [Google Scholar]
  19. Osborn J. E. Jun, Medearis D. N. 1966; Studies of relationship between mouse cytomegalovirus and interferon. Proceedings of the Society for Experimental Biology and Medicine 121:819–824
    [Google Scholar]
  20. Osborn J. E. Jun, Medearis D. N. 1967; Suppression of interferon and antibody and multiplication of Newcastle Disease virus in cytomegalovirus infected mice. Proceedings of the Society for Experimental Biology and Medicine 124:347–353
    [Google Scholar]
  21. Russell A. S., Schlaut J. 1975; HL-A transplantation antigens in subjects susceptible to recrudescent Herpes Labialis. Tissue Antigens 6:257–261
    [Google Scholar]
  22. Selgrade M. K., Osborn J. E. 1974; Role of macrophages in resistance to murine cytomegalovirus. Infection and Immunity 10:1383–1390
    [Google Scholar]
  23. Sheridan J. W., Finlay-Jones J. J. 1977; Studies on a fractionated murine fibrosarcoma: a reproducible method for the cautious and a caution for the unwary. Journal of Cellular Physiology (in the press)
    [Google Scholar]
  24. Starr S. E., Visintine A. M., Tomeh M. O., Nahmias A. J. 1976; Effects of immunostimulants on resistance of newborn mice to herpes simplex type 2 infection. Proceedings of the Society for Experimental Biology and Medicine 152:57–60
    [Google Scholar]
  25. Theis G., Koprowski M. 1961; A cellular basis for virus resistance. Federation Proceedings 20:265
    [Google Scholar]
  26. Valle M. J., Bobrove A. M., Strober S., Merigan T. C. 1975a; Immune specific production of interferon by human T cells in combined macrophage-lymphocyte cultures in response to herpes simplex antigen. Journal of Immunology 114:435–441
    [Google Scholar]
  27. Valle M. J., Jordan G. W., Haahr S., Merigan T. C. 1975b; Characteristics of immune interferon produced by human lymphocyte cultures compared to other human interferons. Journal of Immunology 115:230–233
    [Google Scholar]
  28. Youngner J. S., Salvin S. B. 1973; Production and properties of migration inhibitory factor and interferon in the circulation of mice with delayed hypersensitivity. Journal of Immunology 111:1914–1922
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-37-1-107
Loading
/content/journal/jgv/10.1099/0022-1317-37-1-107
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error