@article{mbs:/content/journal/jgv/10.1099/0022-1317-37-1-107, author = "Chalmer, Jane E. and Mackenzie, J. S. and Stanley, N. F.", title = "Resistance to Murine Cytomegalovirus Linked to the Major Histocompatibility Complex of the Mouse", journal= "Journal of General Virology", year = "1977", volume = "37", number = "1", pages = "107-114", doi = "https://doi.org/10.1099/0022-1317-37-1-107", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-37-1-107", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Summary Studies of the resistance patterns to infection with a murine cytomegalovirus in inbred strains of mice revealed the existence of resistant and susceptible strains. Resistance was found to be associated with possession of the H-2k allele at the major histocompatibility locus of the mouse. The F1 hybrid between a resistant strain (C3H/HeJ) and a susceptible strain (BALB/c) was found to have a resistance intermediate between that of both parents, indicating that the gene(s) controlling resistance is partly dominant. Susceptible BALB/c mice could be made resistant to lethal infection by pre-treatment with thioglycollate broth but not by pre-treatment with endotoxin or BCG. Resistant C3H/HeJ mice could be made susceptible to lethal infection by pre-treatment with cyclophosphamide.", }