1887

Abstract

Summary

The purified fibre and hexon of adenovirus 12 inhibit the transformation in tissue culture of murine sarcoma virus (MSV-M) by as much as 80% and 70%, respectively, when they are added to cells 8 to 20 h before MSV-M infection. During a 12 h period, only about 6 to 8% of added radiolabelled viral proteins become associated with cells (or 1·0 µg protein bound/10 cells). No inhibition occurs when the proteins are added simultaneously with MSV-M or 90 min or 4 h after MSV-M. There is also a direct correlation between the extent of focus inhibition and the concentrations of viral proteins used. Concentrations of viral proteins used to inhibit cell transformation do not affect cell growth, but do reduce cell macromolecular synthesis.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-31-3-437
1976-06-01
2019-10-21
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-31-3-437
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error